公开(公告)号：US20220266241A1

公开(公告)日：2022-08-25

申请号：US17617881

申请日：2020-06-05

Applicant: Siemens Healthcare Diagnostics Inc.

Inventor： Aaron Kauffmann ,  David Ledden

IPC: B01L3/00

Abstract: Devices, kits, and methods separating and metering a plasma sample from a patients liquid test sample.

公开(公告)号：US20220252578A1

公开(公告)日：2022-08-11

申请号：US17597619

申请日：2019-12-05

Applicant: Siemens Healthcare Diagnostics Inc.

Inventor： Aaron Kauffmann ,  David Ledden ,  Jennifer Samproni

IPC: G01N33/52 ,  G01N1/34 ,  B01L3/00

Abstract: A tangent flow hemolysis blood testing assembly, device and method are described herein. The presently disclosed and claimed inventive concept(s) relate to a device(s), kit(s), and method(s) for injecting a patient's liquid test sample into a reaction vessel. More specifically, the presently disclosed and claimed inventive concept(s) relate to an improved liquid test sample injection device that comprises a plug that forms an airtight seal that facilitates the active injection of a liquid test sample into a reaction vessel, and kits and methods of use related thereto.

公开(公告)号：US11040350B2

公开(公告)日：2021-06-22

申请号：US16317951

申请日：2017-07-06

Applicant: Siemens Healthcare Diagnostics Inc.

Inventor： David Ledden

IPC: B01L3/00 ,  G01N33/48

Abstract: Devices, kits, and methods for dispensing at least two liquid reagents for use in analyte(s) detection assays are disclosed.

公开(公告)号：US20180306815A1

公开(公告)日：2018-10-25

申请号：US15524817

申请日：2015-11-17

Applicant: Siemens Healthcare Diagnostics Inc.

Inventor： Krastyu Ugrinov ,  Lloyd Schulman ,  David Ledden ,  Janine Cox ,  Anne Novamo

IPC: G01N33/76 ,  G01N33/53 ,  G01N33/558 ,  C12M1/34 ,  G01N30/90 ,  G01N33/532

CPC classification number: G01N33/76 ,  C12M1/34 ,  G01N30/90 ,  G01N33/5306 ,  G01N33/532 ,  G01N33/558

Abstract: In one aspect, the inventive concepts disclosed herein are directed to a lateral flow assay comprising: one or more chromatographic substrates, a sample application site, a first capture site, and a second capture site. The first capture site comprising an anti-hCG capture antibody with broad affinity for a group of multiple hCG variants and the second capture site comprising an anti-hCG capture antibody that is specific to a first variant of hCG. Additional aspects of the invention disclose using the later flow assay to determine a ratio of the first variant of hCG to the group of multiple hCG variants.

公开(公告)号：US11369314B2

公开(公告)日：2022-06-28

申请号：US16317966

申请日：2017-06-07

Applicant: Siemens Healthcare Diagnostics Inc.

Inventor： David Ledden

IPC: A61B5/1455 ,  A61B5/00 ,  A61B5/145 ,  A61B5/1459 ,  A61K9/00 ,  A61K31/192 ,  A61K31/573 ,  A61K31/616 ,  A61K31/722

Abstract: Devices, kits, and methods for (a) determining the presence and/or concentration of at least one analyte(s) of interest present in a patient's fluid sample and devices and methods of calibration related thereto, and (b) preventing, mitigating, and/or eliminating biofouling of an indwelling, wearable biosensor are disclosed and/or claimed herein.

公开(公告)号：US11339419B2

公开(公告)日：2022-05-24

申请号：US16623959

申请日：2018-07-30

Applicant: Siemens Healthcare Diagnostics Inc.

Inventor： Janine Cox ,  Christopher Lawrence ,  Murli Narayan ,  David Ledden

IPC: G01N33/543 ,  C12Q1/26 ,  A61B5/1473 ,  B05D1/36

Abstract: Composition(s), device(s), kit(s), and method(s) for an improved analyte detection sensor(s) comprising at least one scavenger protein and method(s) of preserving the functioning and functional life of the improved analyte detection sensor(s).

公开(公告)号：US20210382074A1

公开(公告)日：2021-12-09

申请号：US17265964

申请日：2019-07-31

Applicant: Siemens Healthcare Diagnostics Inc.

Inventor： Sudipa Galgalkar ,  Ishita Chakraborty ,  Ragavendar MS ,  David Ledden

IPC: G01N33/72 ,  G01N1/38

Abstract: A composition of a bilimbin stock and a method of preparation are provided. In one aspect of the invention, the composition includes a base solution. The composition further includes a carbonate salt. Additionally, the composition includes bilimbin. Furthermore, the composition includes human serum albumin

公开(公告)号：US11850583B2

公开(公告)日：2023-12-26

申请号：US17617881

申请日：2020-06-05

Applicant: Siemens Healthcare Diagnostics Inc.

Inventor： Aaron Kauffmann ,  David Ledden

IPC: B01L3/00

CPC classification number: B01L3/502 ,  B01L2200/0605 ,  B01L2400/0406

Abstract: Devices, kits, and methods separating and metering a plasma sample from a patient's liquid test sample.

公开(公告)号：US20230400394A1

公开(公告)日：2023-12-14

申请号：US18249325

申请日：2021-10-19

Applicant: Siemens Healthcare Diagnostics Inc.

Inventor： David Ledden ,  Jeffrey Mayfield ,  Hollie Huff

IPC: G01N1/40

CPC classification number: G01N1/4005 ,  G01N2001/4038

Abstract: A method of increasing a concentration of an antigen of a respiratory virus is provided. The method includes preparing a sample containing a first concentration of the antigen; contacting the sample containing the first concentration of the antigen to a first material having a negatively-charged surface, thereby capturing an amount of the antigen with the first material; contacting a second material to the first material to transfer the antigen from the first material to the second material, the second material having an ionic strength sufficient to release the captured antigen from the first material into the second material; and obtaining a resulting solution containing the antigen in a second concentration. The second concentration of the antigen in the resulting solution is higher than the first concentration of the antigen in the sample. Numerous other aspects in accordance with this and other embodiments are provided.

公开(公告)号：US11460476B2

公开(公告)日：2022-10-04

申请号：US17435433

申请日：2020-02-26

Applicant: Siemens Healthcare Diagnostics Inc.

Inventor： Aaron Kauffmann ,  David Ledden ,  Chris Zimmerle ,  Jon Stradinger

IPC: G01N33/72 ,  G01N33/49 ,  G01N33/58 ,  B01L3/00

Abstract: Devices, kits, and methods are disclosed for use in detecting a concentration of an analyte of interest in a patient's liquid test sample. The devices, kits, and methods employ the use of one or more solid reagent zones that includes at least one analytical reagent for detection of an analyte of interest. The solid reagent zone(s) also includes at least one dye for determining whether results obtained from the diagnostic assay for the at least one analyte of interest are biased or inaccurate due to a loss of volume of a liquid reagent during the dispensing of the liquid reagent.