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公开(公告)号：US10513489B2
公开(公告)日：2019-12-24
申请号：US15642789
申请日：2017-07-06
发明人： Ottmar Franz Hueter , Pierre Joseph Marcel Jung , Thomas Pitterna , Helmars Smits , Andre Stoller
IPC分类号： C07C233/81 , A01N37/46 , C07C229/64 , C07C233/76 , C07C255/57 , C07C253/30 , A01N37/22 , C07C231/02 , A01N37/34 , C07C237/44
摘要： The present invention relates to compounds of formula (I) having insecticidal activity to processes and interediates for preparing them, to insecticidal, acaricidal, nematicidal or molluscicidal compositions comprising them and to methods of using them to combat and control insect, acarine, nematode or mollusc pests claim 1: or salts thereof.
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公开(公告)号：US09969734B2
公开(公告)日：2018-05-15
申请号：US14905575
申请日：2014-07-11
发明人： Edouard Godineau , Tomas Smejkal , Sophie Pelletier , Michel Muehlebach , Regis Jean Georges Mondiere , Helmars Smits , Jochen Weckesser , Alan James Robinson
IPC分类号： C07D471/10 , C07D209/54 , C07D211/94 , C07D409/12 , C07C231/06 , C07C233/65 , C07C233/74
CPC分类号： C07D471/10 , C07C231/06 , C07C233/65 , C07C233/74 , C07D209/54 , C07D211/94 , C07D409/12
摘要： A process for making certain spiroheterocyclic pyrrolidine dione derivatives.
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公开(公告)号：US10087126B2
公开(公告)日：2018-10-02
申请号：US15516110
申请日：2015-10-08
发明人： Helmars Smits , Paul Knochel , Thomas Klatt , Matthias Becker
IPC分类号： C07C17/25 , C07C17/383 , C07C17/35 , C07C17/38 , C07C17/013
摘要： The invention relates to a process for the preparation of compound of formula (I) wherein R1 is halogen and R2 is halogen or hydrogen; comprising a) reacting the compound of formula (II) in an aprotic organic solvent in the presence of an aprotic polar co-solvent with a magnesium amide base followed by a halogenating agent, to the compound of formula I wherein R1 is halogen and R2 is hydrogen, and b) reacting the compound of formula (I), wherein R1 is chloro and R2 is hydrogen, in an aprotic organic solvent in the presence of an aprotic polar co-solvent with a magnesium amide base followed by a halogenating agent to a compound of formula I, wherein R1 is chloro and R2 is halogen.
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公开(公告)号：US09643938B2
公开(公告)日：2017-05-09
申请号：US15307386
申请日：2015-04-30
IPC分类号： C07D261/04
CPC分类号： C07D261/04 , C07C259/06 , C07D261/12
摘要： The present invention relates to processes for the preparation of substituted cycloserine compounds of formula (I) wherein R1 is C1-C8alkyl, C1-C8haloalkyl, C3-C6cycloalkyl, aryl or aryl substituted by one to five R11, or aryl-C1-C4alkylene or aryl-C1-C4alkylene substituted by one to five R11; and each R11 is independently C1-C4alkyl, C1-C4haloalkyl, C1-C4alkoxy, C1-C4haloalkoxy, cyano or halogen; The invention also relates to intermediates produced by the processes. Compounds of formula (I) are useful intermediates for the production of compounds in the agricultural and pharmaceutical fields.
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公开(公告)号：US20150291510A1
公开(公告)日：2015-10-15
申请号：US14437206
申请日：2013-10-24
发明人： Ottmar Franz Hueter , Pierre Joseph Marcel Jung , Thomas Pitterna , Helmars Smits , Andre Stoller
IPC分类号： C07C233/81 , A01N37/22 , C07C233/76
CPC分类号： C07C233/81 , A01N37/22 , A01N37/46 , C07C229/64 , C07C233/76 , C07C253/30 , C07C255/57
摘要： The present invention relates to novel triazole derivatives of formula (I) having insecticidal activity, to processes and intermediates for preparing them, to insecticidal, acaricidal, nematicidal or molluscicidal compositions comprising them and to methods of using them to combat and control insect, acarine, nematode or mollusc pests; wherein R1, R2, G1, G2, Q1 and Q2 are as defined in claim 1; or salts thereof.
摘要翻译： 本发明涉及具有杀虫活性的新颖的具有杀虫活性的式（I）的三唑衍生物，其制备方法和中间体，包含它们的杀虫，杀螨，杀线虫或杀软体动物的组合物以及使用它们来对抗和控制昆虫，螨类， 线虫或软体动物害虫; 其中R1，R2，G1，G2，Q1和Q2如权利要求1所定义; 或其盐。
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公开(公告)号：US10093672B2
公开(公告)日：2018-10-09
申请号：US15958059
申请日：2018-04-20
发明人： Edouard Godineau , Tomas Smejkal , Sophie Pelletier , Michel Muehlebach , Régis Jean Georges Mondiere , Helmars Smits , Jochen Weckesser , Alan James Robinson
IPC分类号： C07D471/10 , C07D211/94 , C07D209/54 , C07C233/74 , C07C233/65 , C07D409/12 , C07C231/06
摘要： A process for making certain spiroheterocyclic pyrrolidine dione derivatives.
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公开(公告)号：US09975823B2
公开(公告)日：2018-05-22
申请号：US15515322
申请日：2015-10-08
发明人： Helmars Smits
摘要： The present invention relates to a process for the preparation of a compound of formula I (I), comprising reacting a compound of formula II (II), with a brominating agent in the presence of an acidic catalyst to a compound of formula III (III), and reacting the compound of formula III in tetrahydrofuran or 2-methyl-tetrahydrofuran with potassium tert-butoxide to a compound of formula I.
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公开(公告)号：US09815829B2
公开(公告)日：2017-11-14
申请号：US15501008
申请日：2015-08-04
发明人： Tomas Smejkal , Helmars Smits
IPC分类号： C07D215/00 , C07D261/14 , C07D453/04 , B01J31/02
CPC分类号： C07D453/04 , B01J31/02 , B01J31/0244 , C07B53/00 , C07D261/08 , C07D261/14
摘要： The present invention relates to a process for the preparation of a compound of formula (I) wherein A1 and A2 are C—H, or one of A1 and A2 is C—H and the other is N; R1 is C1-C4alkyl, C1-C4haloalkyl or C3-C6cycloalkyl; each R2 is independently bromo, chloro, fluoro or trifluoromethyl; R3 is hydrogen; R4 is hydrogen, halogen, methyl, halomethyl or cyano; or R3 and R4 together form a bridging 1,3-butadiene group; R5 is chlorodifluoromethyl or trifluoromethyl; n is 2 or 3; by reacting a compound of formula (II) wherein A1, A2, R1, R2, R3, R4, R5 and n is as defined under formula (I) above, with hydroxylamine, a base and a chiral catalyst, characterized in that the chiral catalyst is a dimeric chiral catalyst of formula (III) wherein R6, R7, R8, R9, R10 and X are as defined in claim 1.
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9.发明授权公开(公告)号：US09598369B2
公开(公告)日：2017-03-21
申请号：US14782033
申请日：2014-04-01
发明人： Helmars Smits , Thomas Pitterna , Ottmar Franz Hueter , Andrew Edmunds , Andre Stoller , Pierre Joseph Marcel Jung
IPC分类号： C07D211/78 , C07D211/90 , C07D213/81 , C07C255/57 , C07C233/15 , C07C253/30 , C07D213/82
CPC分类号： C07D213/81 , C07C233/15 , C07C253/30 , C07C255/57 , C07D213/82
摘要： The present invention provides a novel and improved process for the production of the production of hindered anilines containing perfluoroalky groups in good yield any by using close to stoichiometric amounts of acylating agent.
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公开(公告)号：US09469633B2
公开(公告)日：2016-10-18
申请号：US14346773
申请日：2012-09-28
发明人： Tomas Smejkal , Helmars Smits , Sebastian Volker Wendeborn , Guillaume Berthon , Jerome Yves Cassayre , Myriem El Qacemi
IPC分类号： C07D207/408 , C07D207/40 , C07D207/404 , C08F8/32 , C07D207/412 , C07D207/325 , C07C255/41 , C07C253/10 , C07C253/30 , C07D453/04 , C07D409/12 , C07D207/08 , C07D207/267 , C07D207/333 , C07D307/46 , C07C255/40 , C07D207/12
CPC分类号： C07D453/04 , C07C253/10 , C07C253/30 , C07C255/40 , C07C255/41 , C07D207/08 , C07D207/12 , C07D207/267 , C07D207/325 , C07D207/333 , C07D207/40 , C07D307/46 , C07D409/12
摘要： The present invention relates to processes for the enantio-selective preparation of spyrrolidine derivatives useful in the manufacture of pesticidally active compounds, as well as to intermediates in the processes. The processes include those comprising(a-i) reacting a compound of formula Ia wherein P is alkyl, aryl or heteroaryl, each optionally substituted, wherein the heteroaryl is connected at P via a ring carbon atom; R1 is chlorodifluoromethyl or trifluoromethyl; R2 is aryl or heteroaryl, each optionally substituted; with a source of cyanide in the presence a chiral catalyst to give a compound of formula IIa wherein P, R1 and R2 are as defined for the compound of formula Ia; and (a-ii) oxidizing the compound of formula IIa with a peroxy acid, or peroxide in the presence of an acid to give a compound of formula VI wherein R1 and R2 are as defined for the compound of formula Ia.
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