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1.发明授权Inhibitors of the activity of complex (III) of the mitochondrial electron transport chain and use thereof 有权线粒体电子传递链复合物（III）的活性抑制剂及其用途公开(公告)号：US09458174B2
公开(公告)日：2016-10-04
申请号：US14401685
申请日：2013-05-23
IPC分类号： A61K31/41 , C07D495/10 , C07D213/81 , C07D215/28 , C07C275/42 , C07C39/30 , C07D231/56 , C07C311/08 , C07D235/26 , C07D405/12 , C07C215/50 , C07D249/06 , C07C233/25 , C07D263/32 , C07D263/34 , C07D487/10 , C07C237/38 , C07C237/42 , C07C251/48 , C07D209/42 , C07D305/06 , C07C49/825 , C07D403/12 , C07D223/28 , C07D235/18 , C07C233/33 , C07D261/08 , C07C235/60 , C07C235/62 , C07D263/57 , C07D491/107 , C07C237/40 , C07C237/44 , C07D277/56 , C07D513/10 , C07D305/08 , A01N31/08 , A01N33/10 , A01N35/04 , A01N37/24 , A01N37/40 , A01N37/44 , A01N37/46 , A01N37/50 , A01N43/20 , A01N43/38 , A01N43/40 , A01N43/42 , A01N43/46 , A01N43/52 , A01N43/56 , A01N43/60 , A01N43/647 , A01N43/76 , A01N43/78 , A01N43/80 , A01N43/90 , A01N47/30 , C07C39/24 , C07C43/178 , C07C49/245 , A61K31/137 , A61K31/167 , A61K31/17 , A61K31/18 , A61K31/397 , A61K31/421 , A61K31/44 , A61K31/47 , A61K31/55 , A61K45/06 , C07D223/24
CPC分类号： C07D495/10 , A01N31/08 , A01N33/10 , A01N35/04 , A01N37/24 , A01N37/40 , A01N37/44 , A01N37/46 , A01N37/50 , A01N43/20 , A01N43/38 , A01N43/40 , A01N43/42 , A01N43/46 , A01N43/52 , A01N43/56 , A01N43/60 , A01N43/647 , A01N43/76 , A01N43/78 , A01N43/80 , A01N43/90 , A01N47/30 , A61K31/137 , A61K31/167 , A61K31/17 , A61K31/18 , A61K31/397 , A61K31/421 , A61K31/44 , A61K31/47 , A61K31/55 , A61K45/06 , C07C39/245 , C07C39/30 , C07C43/1787 , C07C49/245 , C07C49/825 , C07C215/50 , C07C233/25 , C07C233/33 , C07C235/60 , C07C235/62 , C07C237/38 , C07C237/40 , C07C237/42 , C07C237/44 , C07C251/48 , C07C275/42 , C07C311/08 , C07C2601/04 , C07C2601/14 , C07C2601/18 , C07C2602/08 , C07C2602/42 , C07C2603/74 , C07D209/42 , C07D213/81 , C07D215/28 , C07D223/24 , C07D223/28 , C07D231/56 , C07D235/18 , C07D235/26 , C07D249/06 , C07D261/08 , C07D263/32 , C07D263/34 , C07D263/57 , C07D277/56 , C07D305/06 , C07D305/08 , C07D403/12 , C07D405/12 , C07D487/10 , C07D491/107 , C07D513/10
摘要： The present invention relates to inhibitors of the activity of Complex (III) of the mitochondrial electron transport chain and use thereof in treatment and/or prevention of cancers presenting tumor-initiating cells. The present invention further relates to pharmaceutical compositions containing said inhibitors alone or in combination with other pharmaceutically active agents, and their use as medicaments or as agrochemicals where their properties as inhibitors of the mitochondrial respiration is of benefit.
摘要翻译： 本发明涉及线粒体电子传递链的复合体（III）的活性抑制剂及其在治疗和/或预防呈递肿瘤起始细胞的癌症中的用途。 本发明还涉及单独或与其它药物活性剂组合含有所述抑制剂的药物组合物，以及它们作为药物或作为农药的用途，其中其作为线粒体呼吸抑制剂的性质是有益的。
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2.发明申请INHIBITORS OF THE ACTIVITY OF COMPLEX (III) OF THE MITOCHONDRIAL ELECTRON TRANSPORT CHAIN AND USE THEREOF 有权咪唑电子传输链复合物（III）的活性抑制剂及其用途公开(公告)号：US20150148301A1
公开(公告)日：2015-05-28
申请号：US14401685
申请日：2013-05-23
IPC分类号： C07D495/10 , A61K31/167 , A61K45/06 , C07D213/81 , A61K31/44 , C07D215/28 , A61K31/47 , C07C311/08 , A61K31/18 , C07C275/42 , A61K31/17 , C07C215/50 , A61K31/137 , C07D263/34 , A61K31/421 , C07D223/24 , A61K31/55 , A61K31/397 , C07C237/44
CPC分类号： C07D495/10 , A01N31/08 , A01N33/10 , A01N35/04 , A01N37/24 , A01N37/40 , A01N37/44 , A01N37/46 , A01N37/50 , A01N43/20 , A01N43/38 , A01N43/40 , A01N43/42 , A01N43/46 , A01N43/52 , A01N43/56 , A01N43/60 , A01N43/647 , A01N43/76 , A01N43/78 , A01N43/80 , A01N43/90 , A01N47/30 , A61K31/137 , A61K31/167 , A61K31/17 , A61K31/18 , A61K31/397 , A61K31/421 , A61K31/44 , A61K31/47 , A61K31/55 , A61K45/06 , C07C39/245 , C07C39/30 , C07C43/1787 , C07C49/245 , C07C49/825 , C07C215/50 , C07C233/25 , C07C233/33 , C07C235/60 , C07C235/62 , C07C237/38 , C07C237/40 , C07C237/42 , C07C237/44 , C07C251/48 , C07C275/42 , C07C311/08 , C07C2601/04 , C07C2601/14 , C07C2601/18 , C07C2602/08 , C07C2602/42 , C07C2603/74 , C07D209/42 , C07D213/81 , C07D215/28 , C07D223/24 , C07D223/28 , C07D231/56 , C07D235/18 , C07D235/26 , C07D249/06 , C07D261/08 , C07D263/32 , C07D263/34 , C07D263/57 , C07D277/56 , C07D305/06 , C07D305/08 , C07D403/12 , C07D405/12 , C07D487/10 , C07D491/107 , C07D513/10
摘要： The present invention relates to inhibitors of the activity of Complex (III) of the mitochondrial electron transport chain and use thereof in treatment and/or prevention of cancers presenting tumour-initiating cells. The present invention further relates to pharmaceutical compositions containing said inhibitors alone or in combination with other pharmaceutically active agents, and their use as medicaments or as agrochemicals where their properties as inhibitors of the mitochondrial respiration is of benefit.
摘要翻译： 本发明涉及线粒体电子传递链的复合体（III）的活性抑制剂及其在治疗和/或预防呈递肿瘤起始细胞的癌症中的用途。 本发明还涉及单独或与其它药物活性剂组合含有所述抑制剂的药物组合物，以及它们作为药物或作为其作为线粒体呼吸抑制剂的性质有益的农药的用途。
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