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1.发明申请公开(公告)号：US20210174509A1
公开(公告)日：2021-06-10
申请号：US17094254
申请日：2020-11-10
申请人： Shimadzu Corporation
发明人： Hiroshi IWATA , Shigehiko ZODA , Eiichi OZEKI , Ippei TAKEUCHI , Hiroomi GOTO , Yasuko YONEDA , Takahiro NISHIMOTO , Toyoyuki HASHIMOTO
摘要： An object is to obtain not only information indicating whether or not a drug is effective against bacteria but also additional information about an effective drug. An examination method includes a sample preparation step of obtaining a plurality of samples by bringing drugs of a plurality of types into contact with bacteria, and an image capturing step of capturing an image of each sample. The examination method includes a step of determining efficacy of the drug based on each sample image obtained in the image capturing step, and a step of obtaining drug susceptibility information by comparing a plurality of sample images including the drug determined as being effective, in accordance with a prescribed criterion.
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公开(公告)号：US20210165202A1
公开(公告)日：2021-06-03
申请号：US17106340
申请日：2020-11-30
申请人： SHIMADZU CORPORATION
发明人： Hiroshi IWATA , Shigehiko ZODA , Hiroomi GOTO , Eiichi OZEKI , Yasuko YONEDA , Takahiro NISHIMOTO , Naofumi SAKAUCHI , Ippei TAKEUCHI
摘要： One object is to reduce the time required for focusing. When an image capturing condition is not stored (when image capturing of an observation area is performed for the first time), an examination device performs an autofocus process, obtains a focus position where a microscope camera is in focus on the observation area, and stores the obtained focus position in a storage device. In contrast, when the image capturing condition is stored (when image capturing of the observation area is performed for the second and subsequent times), the examination device captures an image of the observation area by reading out the focus position from the storage device and setting a focal point of the microscope camera at the read-out focus position.
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公开(公告)号：US20240076596A1
公开(公告)日：2024-03-07
申请号：US18268670
申请日：2021-10-14
申请人： Shimadzu Corporation
发明人： Tsunehiro INOUE , Toyoyuki HASHIMOTO , Yasuko YONEDA , Kenji TAKUBO , Yoichi FUJIYAMA , Tomoki OHKUBO , Eiichi OZEKI , Ryogo TAKAI , Hiroomi GOTO , Sadamu TOMITA
摘要： A cell culture container includes: an insert member having a membrane on which a cell is seeded, the insert member defining a first inner space that functions as an anaerobic chamber; a container having an attachment/detachment portion to and from which the insert member is attachable and detachable, the container defining a second inner space that functions as an aerobic chamber; a sealing member that closes an opening of the aerobic chamber between the attachment/detachment portion and the insert member with the insert member being attached to the attachment/detachment portion; and a transfer mechanism that transfers force to the sealing member. The sealing member closes the opening in response to an input of the force from the transfer mechanism.
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公开(公告)号：US20230220323A1
公开(公告)日：2023-07-13
申请号：US18014876
申请日：2021-06-23
申请人： SHIMADZU CORPORATION
摘要： A cell culture system includes: a first pump; and a first cell culture container and a second cell culture container. The first cell culture container has a first culture medium circulation flow path. The second cell culture container has a second culture medium circulation flow path independent of the first culture medium circulation flow path. The first culture medium circulation flow path and the second culture medium circulation flow path are fluidly connected to the first pump.
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公开(公告)号：US20230313103A1
公开(公告)日：2023-10-05
申请号：US18022592
申请日：2021-07-07
申请人： Shimadzu Corporation
发明人： Tsunehiro INOUE , Toyoyuki HASHIMOTO , Yasuko YONEDA , Kenji TAKUBO , Yoichi FUJIYAMA , Tomoki OHKUBO , Eiichi OZEKI , Ryogo TAKAI , Hiroomi GOTO , Sadamu TOMITA
摘要： A cell culture container includes: a container body; a cell culture insert having a tubular portion and an oxygen-permeable membrane; and a lid member. The container body is provided with an opening that communicates with an interior of the container body. The tubular portion includes an upper end and a lower end, and is inserted in the opening such that the lower end is located inside the container body. The lower end side of the tubular portion is closed by the membrane. The upper end side of the tubular portion is closed by the lid member. The lid member includes a lower surface that faces toward an interior of the tubular portion. The lid member is provided with an electrode insertion port and a culture medium outlet port that each communicate with the interior of the tubular portion at the lower surface.
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公开(公告)号：US20230287326A1
公开(公告)日：2023-09-14
申请号：US18014866
申请日：2021-05-31
申请人： Shimadzu Corporation
发明人： Yasuko YONEDA , Tomoki OHKUBO , Toyoyuki HASHIMOTO
摘要： A cell culture system includes: a cell culture container disposed in an anaerobic chamber; and an external apparatus. The external apparatus has a main body unit disposed in the anaerobic chamber and an operation unit disposed outside the anaerobic chamber. The main body unit is configured to perform a predetermined process onto the cell culture container. The operation unit is configured to transmit or receive a signal associated with the predetermined process to or from the main body unit by wireless communication.
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公开(公告)号：US20220387298A1
公开(公告)日：2022-12-08
申请号：US17704653
申请日：2022-03-25
申请人： Shimadzu Corporation
发明人： Shigeaki SHIBAMOTO , Yasuko YONEDA , Ryogo TAKAI , Kohei YAMAMOTO
摘要： The present invention chiefly aims to provide a novel composition for controlling indigenous bacterial flora in the skin which can enhance or improve the diversity of bacterial species in the indigenous bacterial flora in the skin relative to the condition before treatment. The present invention can include, for example, a composition (e.g., an ointment, a liquid) for controlling the diversity of bacterial species in indigenous bacterial flora in the skin, comprising an effective amount of earthworm lipids extracted from a raw earthworm (Lumbricus rubellus), and a base. The composition of the present invention is useful, for example, as a raw material for skin care products and cosmetics.
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公开(公告)号：US20220308080A1
公开(公告)日：2022-09-29
申请号：US17615893
申请日：2020-05-25
申请人： Shimadzu Corporation
发明人： Hiroshi IWATA , Hiroomi GOTO , Shigehiko ZODA , Eiichi OZEKI , Takahiro NISHIMOTO , Aline ROTZETTER , Yasuko YONEDA , Ippei TAKEUCHI
摘要： A testing method using a micro flow path device configured for a test liquid containing a specimen to be brought into contact with a drug therein and for a test on an action of the drug on the specimen includes: preparing the micro flow path device including: a plurality of micro flow paths, first and second openings which are disposed at both ends of each of the plurality of micro flow paths and communicate with an outside, a storage unit which is provided in each of the plurality of micro flow paths and stores the drug, and a gas-permeable membrane covering the first opening; applying a fluid pressure higher than an external pressure to the test liquid through the second opening from a syringe pump connected to the second opening to pressure-feed the test liquid to the storage unit; and observing a target region set in the micro flow path.
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