公开(公告)号：US20210156831A1

公开(公告)日：2021-05-27

申请号：US16769001

申请日：2017-12-05

申请人： SHIMADZU CORPORATION

发明人： Kohei YAMAMOTO

IPC分类号： G01N30/72 ,  G01N27/62 ,  G01N30/86

摘要： A data storage section stores LC/MS analysis data for a large number of culture-medium samples acquired with an LC-MS. Based on those data, a quantitative analyzer calculates concentration values of a large number of compounds in each sample and stores the result in an analysis result storage section. A result display processor retrieves analysis results with the same culture name and different sampling date from the analysis result storage section, creates a table in which concentration values are arranged for each compound and for each sampling date, as well as a graph showing a temporal change in the concentration value of one compound, and displays the table and graph on the same window on a display unit. An operator using an operation unit selects a compound on the displayed table. The result display processor creates a graph for the selected compound and renews the graph on the display.

公开(公告)号：US20220387298A1

公开(公告)日：2022-12-08

申请号：US17704653

申请日：2022-03-25

申请人： Shimadzu Corporation

发明人： Shigeaki SHIBAMOTO ,  Yasuko YONEDA ,  Ryogo TAKAI ,  Kohei YAMAMOTO

IPC分类号： A61K8/98 ,  A61Q17/00 ,  A61Q19/00

摘要： The present invention chiefly aims to provide a novel composition for controlling indigenous bacterial flora in the skin which can enhance or improve the diversity of bacterial species in the indigenous bacterial flora in the skin relative to the condition before treatment. The present invention can include, for example, a composition (e.g., an ointment, a liquid) for controlling the diversity of bacterial species in indigenous bacterial flora in the skin, comprising an effective amount of earthworm lipids extracted from a raw earthworm (Lumbricus rubellus), and a base. The composition of the present invention is useful, for example, as a raw material for skin care products and cosmetics.

公开(公告)号：US20180156761A1

公开(公告)日：2018-06-07

申请号：US15576467

申请日：2015-05-26

申请人： Shimadzu Corporation

发明人： Kohei YAMAMOTO

IPC分类号： G01N30/24 ,  G01N35/00

摘要： An automatic analysis device capable of effectively preventing incorrect container number input when analysis conditions are set. An image display area and text display area are provided in a setting screen. An image in which a selection area is assigned to each container number corresponding to a sample container is displayed in the image display area. If a selection area in the image display area is selected through operation unit operation, the container number expressing the selected selection area is displayed in the text display area (container number input part). If the container number expressing the selected sample container is displayed in the text display area (container number input part) as a result of operation unit operation, the display mode of the selection area corresponding to the container number is switched.

公开(公告)号：US20200309747A1

公开(公告)日：2020-10-01

申请号：US16756044

申请日：2017-12-05

申请人： Shimadzu Corporation

发明人： Kohei YAMAMOTO

IPC分类号： G01N30/72 ,  G01N27/62 ,  G01N30/86 ,  G01N35/00

摘要： A display control unit (52) displays a screen for setting sample information on a display unit (8) for each sample placed in a sample placement section (20), and an input processing unit (53) receives information such as a culture name and seeding date and time information input by an operator via an operation unit (7), and stores the information in a storage unit (55). This file is transferred to a data processing unit (4) and stored in a sample information storage unit (40). After analyzing the respective samples in an LC-MS (3), a quantitative analysis unit (42) performs a quantitative analysis based on the obtained data, associates the analysis result with the sample information, and stores the data in an analysis result storage unit (43). As a result, the sample information and the analysis result of the respective samples in the preprocessing stage are associated with each other. Result display processing unit (44) arranges sample information and an analysis result for one sample on the same screen and displays them on display unit (8). With this display, an operator can easily and accurately grasp the correspondence relationship between the sample information and the analysis result of a plurality of sample to be subjected to preprocessing.

公开(公告)号：US20210147786A1

公开(公告)日：2021-05-20

申请号：US16756225

申请日：2017-12-05

申请人： Shimadzu Corporation

发明人： Kohei YAMAMOTO

IPC分类号： C12M1/36 ,  G01N27/62 ,  G01N35/00 ,  C12M1/34

摘要： On a device state confirmation screen (100), a first sample arrangement image (111) showing a top-view image of a sample placement section in a preprocessing device for performing preprocessing of removal of proteins or the like and a second sample arrangement image (121) showing a top-view image of a sample placement section of an auto-sampler of an LC-MS are simultaneously displayed. In the respective sample arrangement images (111, 121), a placement position of a vial is indicated by a circular region (113, 122), and the same vial number A1, A2, . . . , is assigned to a vial in which one culture medium sample is accommodated and a vial in which a preprocessed sample is accommodated. Further, circular regions 113 and 122 are displayed in different display colors depending on a state of progress of the preprocessing operation and the analysis operation. As a result, an operator can visually recognize easily and assuredly the correspondence relationship between positions of a large number of vials placed in the sample placement section and positions of a large number of vials accommodating preprocessed samples placed in the auto-sampler, which prevents erroneous selection of samples.

公开(公告)号：US20200319148A1

公开(公告)日：2020-10-08

申请号：US16767520

申请日：2017-12-01

申请人： Shimadzu Corporation

发明人： Kohei YAMAMOTO

IPC分类号： G01N30/72 ,  G01N30/06 ,  G01N30/86

摘要： Before repeating the processing that an LC/MS analysis is performed after diluting a large number of pretreated media samples (S16 to S19), an LC-MS stabilization processing (S11) of supplying a mobile phase to the LC-MS and performing an analysis without a sample according to the same gradient profile as that in a culture medium sample analysis and a standard sample analysis (S13) of supplying a standard sample to the LC-MS and obtaining data for generating a calibration curve are performed. Before the LC-MS stabilization processing and before the standard sample analysis, respectively, a standby time corresponding to a required time of a sample dilution is provided (Steps S10 and S12). With this, the time of the cycle including the LC-MS stabilization processing and the time of the cycle including the standard sample analysis are made to be the same as the time of the cycle of a dilution and an analysis to a culture medium sample. As a result, the stoppage time of the mobile phase before the mobile phase is fed according to the gradient profile becomes the same in every cycle, and the staying time of the mobile phase in the degassing device becomes uniform, so that it is possible to avoid changes in the compositions of the mobile phases in the column and to achieve higher quantitativity.