公开(公告)号：US20240226453A9

公开(公告)日：2024-07-11

申请号：US18534306

申请日：2023-12-08

申请人： Sanofi

发明人： Michael Jugl ,  Stefan Blancke ,  Axel Teucher ,  Ralph Donald Quentin Collings ,  James Robert Coop ,  James Anthony West ,  Stephen Francis Gilmore ,  Daniel David Higgins ,  Mark Digby Teucher ,  Anthony Paul Morris ,  Matthew Meredith Jones ,  William Geoffrey Arthur Marsh ,  Samuel Keir Steel

IPC分类号： A61M5/315

CPC分类号： A61M5/31585 ,  A61M5/31526 ,  A61M5/31553 ,  A61M2005/3143

摘要： A drive train for a wind-up injection device is described. The drive train includes a torsional energy storage adapted to be loaded or unloaded by a rotatable element, a rotatable user handle, a rotationally driveable expelling mechanism adapted to expel the liquid drug, and a clutch element coupled with the torsional energy storage via the rotatable element and including a ratchet for maintaining the rotatable element at one of a number of discrete angular positions against the torque of the torsional energy storage. The clutch element is adapted to transmit the torque from the user handle to the torsional energy storage, or alternatively from the torsional energy storage to the expelling mechanism. The ratchet is switchable from one position to an adjacent position by a torque transmitted from the user handle to the torsional energy storage. The drive train is adapted to dampen torque peaks visco-elastically and/or visco-frictionally.

公开(公告)号：US11497854B2

公开(公告)日：2022-11-15

申请号：US16766204

申请日：2018-11-27

申请人： SANOFI

发明人： Ralph Donald Quentin Collings ,  James Robert Coop ,  James Anthony West ,  Stephen Francis Gilmore ,  Daniel David Higgins ,  Mark Digby Teucher ,  Stefan Blancke

IPC分类号： A61M5/315

摘要： A system comprises a first member, a second member, and a third member, wherein the first and second members are rotatable relative to the third member, wherein the first and second members are coupled to one another by a dead-angle follower coupling, wherein the dead-angle follower coupling is configured such that the first and second members are rotatable relative to one another, wherein the second and third members are rotationally coupled to one another by a switchable coupling mechanism, wherein the switchable coupling mechanism is switchable between two different states, a locked state and a non-locked state, wherein the maximum torque transferable between the second and third members via the switchable coupling mechanism in the locked state is greater than in the non-locked state, wherein the switchable coupling mechanism is in the locked state when the first member is in a locking position relative to the second member.

公开(公告)号：US10549046B2

公开(公告)日：2020-02-04

申请号：US14914848

申请日：2014-09-03

申请人： Sanofi

发明人： Simon Lewis Bilton ,  Robert Veasey ,  Matthew Jones ,  David Aubrey Plumptre ,  William Marsh ,  Michael Bainton ,  Daniel David Higgins

IPC分类号： A61M5/315

摘要： A drive mechanism (1) for use in a drug delivery device (100) is provided. The drive mechanism (1) comprises a housing (10, 11, 12, 14, 15) with a proximal and a distal end and a piston rod (22) which is rotatable with respect to the housing (10, 11, 12, 14, 15). The drive mechanism (1) further comprises a nut member (31) which is selectively rotationally lockable with respect to the housing (10, 11, 12, 14, 15), wherein the drive mechanism (1) is switchable between a setting mode of operation and a dispensing mode of operation. The drive mechanism (1) is configured such that in the setting mode of operation, the nut member (31) and the piston rod (22) are rotatable with respect to the housing (10, 11, 12, 14, 15), and in the dispensing mode of operation, the piston rod (22) is rotatable with respect to the housing (10, 11, 12, 14, 15) and the nut member (31) is rotationally locked with respect to the housing (10, 11, 12, 14, 15), wherein, when the piston rod (22) rotates, the piston rod (22) moves distally with respect to the nut member (31).

公开(公告)号：US10092705B2

公开(公告)日：2018-10-09

申请号：US14783156

申请日：2014-04-08

申请人： Sanofi

发明人： Daniel David Higgins ,  Joseph Butler ,  David Aubrey Plumptre ,  Matthew Jones

IPC分类号： A61M5/315 ,  A61M5/31

摘要： The invention refers to an injection device comprising a housing (10), containing a cartridge (170) with an amount of liquid to be dispensed, a drive sleeve (41), which is rotationally constrained to the housing (10) during dose setting and spring driven rotatable relative to the housing (10) during dose dispensing, a dose dial member (60) for setting a dose to be dispensed, which is rotatable relative to the housing (10) during dose setting and during dose dispensing, and which is rotationally coupled to the drive sleeve (41) during dose dispensing. The device further comprises a last dose protection mechanism (41, 50, 60) for preventing the setting of a dose, which exceeds the amount of liquid left in the cartridge (170), with a limiter (50), which is interposed between the drive sleeve (41) and the dose dial member (60). Further, the device comprises two different display members (110, 120), each indicating the set dose.

公开(公告)号：US20240131271A1

公开(公告)日：2024-04-25

申请号：US18534306

申请日：2023-12-08

申请人： Sanofi

发明人： Michael Jugl ,  Stefan Blancke ,  Axel Teucher ,  Ralph Donald Quentin Collings ,  James Robert Coop ,  James Anthony West ,  Stephen Francis Gilmore ,  Daniel David Higgins ,  Mark Digby Teucher ,  Anthony Paul Morris ,  Matthew Meredith Jones ,  William Geoffrey Arthur Marsh ,  Samuel Keir Steel

IPC分类号： A61M5/315

CPC分类号： A61M5/31585 ,  A61M5/31526 ,  A61M5/31553 ,  A61M2005/3143

摘要： A drive train for a wind-up injection device is described. The drive train includes a torsional energy storage adapted to be loaded or unloaded by a rotatable element, a rotatable user handle, a rotationally driveable expelling mechanism adapted to expel the liquid drug, and a clutch element coupled with the torsional energy storage via the rotatable element and including a ratchet for maintaining the rotatable element at one of a number of discrete angular positions against the torque of the torsional energy storage. The clutch element is adapted to transmit the torque from the user handle to the torsional energy storage, or alternatively from the torsional energy storage to the expelling mechanism. The ratchet is switchable from one position to an adjacent position by a torque transmitted from the user handle to the torsional energy storage. The drive train is adapted to dampen torque peaks visco-elastically and/or visco-frictionally.

公开(公告)号：US11918794B2

公开(公告)日：2024-03-05

申请号：US16760121

申请日：2018-10-30

申请人： SANOFI

发明人： Ralph Donald Quentin Collings ,  James Robert Coop ,  James Anthony West ,  Stephen Francis Gilmore ,  Daniel David Higgins ,  Mark Digby Teucher ,  Matthew Meredith Jones ,  Anthony Paul Morris ,  Sophie Sladen ,  William Geoffrey Arthur Marsh ,  Denny Lustosa Horn ,  Stefan Blancke ,  Michael Jugl

IPC分类号： A61M5/315 ,  H01H3/12 ,  A61B17/00

CPC分类号： A61M5/31585 ,  H01H3/12 ,  A61B2017/00367 ,  A61M2205/33 ,  A61M2205/43 ,  A61M2205/581 ,  A61M2205/582

摘要： A button for a drug delivery device with a reduced operating loudness includes a plate-like button body forming a touch surface, wherein the plate-like button body is coupled by an axial supporting member to a noise-generating interface of the drug delivery device and movable into a longitudinal direction of the drug delivery device, wherein the plate-like button body includes a material composite with at least one first component consisting of a first material and at least one second component consisting of a second material different from the first material, wherein the at least one first component and the at least one second component are coupled via at least one coupling plane that is at least sectionwise slanted or perpendicular to the longitudinal direction. Further, the disclosure describes a button assembly for a drug delivery device which is shock resistant.

公开(公告)号：US11565052B2

公开(公告)日：2023-01-31

申请号：US16766204

申请日：2018-11-27

申请人： SANOFI

发明人： Ralph Donald Quentin Collings ,  James Robert Coop ,  James Anthony West ,  Stephen Francis Gilmore ,  Daniel David Higgins ,  Mark Digby Teucher ,  Stefan Blancke

IPC分类号： A61M5/315

摘要： A system comprises a first member, a second member, and a third member, wherein the first and second members are rotatable relative to the third member, wherein the first and second members are coupled to one another by a dead-angle follower coupling, wherein the dead-angle follower coupling is configured such that the first and second members are rotatable relative to one another, wherein the second and third members are rotationally coupled to one another by a switchable coupling mechanism, wherein the switchable coupling mechanism is switchable between two different states, a locked state and a non-locked state, wherein the maximum torque transferable between the second and third members via the switchable coupling mechanism in the locked state is greater than in the non-locked state, wherein the switchable coupling mechanism is in the locked state when the first member is in a locking position relative to the second member.

公开(公告)号：US20160220760A1

公开(公告)日：2016-08-04

申请号：US14914848

申请日：2014-09-03

申请人： SANOFI

发明人： Simon Lewis Bilton ,  Robert Veasey ,  Matthew Jones ,  David Aubrey Plumptre ,  William Marsh ,  Michael Bainton ,  Daniel David Higgins

IPC分类号： A61M5/315

摘要： A drive mechanism (1) for use in a drug delivery device (100) is provided. The drive mechanism (1) comprises a housing (10, 11, 12, 14, 15) with a proximal and a distal end and a piston rod (22) which is rotatable with respect to the housing (10, 11, 12, 14, 15). The drive mechanism (1) further comprises a nut member (31) which is selectively rotationally lockable with respect to the housing (10, 11, 12, 14, 15), wherein the drive mechanism (1) is switchable between a setting mode of operation and a dispensing mode of operation. The drive mechanism (1) is configured such that in the setting mode of operation, the nut member (31) and the piston rod (22) are rotatable with respect to the housing (10, 11, 12, 14, 15), and in the dispensing mode of operation, the piston rod (22) is rotatable with respect to the housing (10, 11, 12, 14, 15) and the nut member (31) is rotationally locked with respect to the housing (10, 11, 12, 14, 15), wherein, when the piston rod (22) rotates, the piston rod (22) moves distally with respect to the nut member (31).

摘要翻译： 提供了一种用于药物输送装置（100）的驱动机构（1）。 驱动机构（1）包括具有近端和远端的壳体（10,11,12,14,15）和可相对于壳体（10,11,12,14和15）旋转的活塞杆（22） ，15）。 驱动机构（1）还包括螺母构件（31），该螺母构件相对于壳体（10,11,12,14,15）选择性地可旋转地锁定，其中驱动机构（1）可以在 操作和分配操作模式。 驱动机构（1）构造成使得在设定操作模式下，螺母构件（31）和活塞杆（22）能够相对于壳体（10,11,12,14,15）旋转，并且 在分配操作模式中，活塞杆（22）可相对于壳体（10,11,12,14,15）旋转，并且螺母构件（31）相对于壳体（10,11）旋转地锁定 ，12,14,15），其中，当活塞杆（22）旋转时，活塞杆（22）相对于螺母构件（31）向远侧移动。

公开(公告)号：US20200368446A1

公开(公告)日：2020-11-26

申请号：US16766204

申请日：2018-11-27

申请人： SANOFI

发明人： Ralph Donald Quentin Collings ,  James Robert Coop ,  James Anthony West ,  Stephen Francis Gilmore ,  Daniel David Higgins ,  Mark Digby Teucher ,  Stefan Blancke

IPC分类号： A61M5/315

摘要： A system comprises a first member, a second member, and a third member, wherein the first and second members are rotatable relative to the third member, wherein the first and second members are coupled to one another by a dead-angle follower coupling, wherein the dead-angle follower coupling is configured such that the first and second members are rotatable relative to one another, wherein the second and third members are rotationally coupled to one another by a switchable coupling mechanism, wherein the switchable coupling mechanism is switchable between two different states, a locked state and a non-locked state, wherein the maximum torque transferable between the second and third members via the switchable coupling mechanism in the locked state is greater than in the non-locked state, wherein the switchable coupling mechanism is in the locked state when the first member is in a locking position relative to the second member.

公开(公告)号：US20200345945A1

公开(公告)日：2020-11-05

申请号：US16479790

申请日：2018-01-22

申请人： SANOFI

发明人： Michael Jugl ,  Stefan Blancke ,  Axel Teucher ,  Ralph Donald Quentin Collings ,  James Robert Coop ,  James Anthony West ,  Stephen Francis Gilmore ,  Daniel David Higgins ,  Mark Digby Teucher ,  Anthony Paul Morris ,  Matthew Meredith Jones ,  William Geoffrey Arthur Marsh ,  Samuel Keir Steel

IPC分类号： A61M5/315

摘要： A drive train (T) for a wind-up injection device (1) for injecting a liquid drug comprises a torsional energy storage (9) adapted to be loaded or unloaded by a rotatable element (6), a rotatable user handle (8), a rotationally driveable expelling mechanism (5) adapted to expel the liquid drug and a clutch element (12) coupled with the torsional energy storage (9) via the rotatable element (6) and comprising a ratchet (12.4) for maintaining the rotatable element (6) at one of a number of discrete angular positions against the torque of the torsional energy storage (9). The clutch element (12) is adapted to transmit a torque from the user handle (8) via the rotatable element (6) to the torsional energy storage (9) or alternatively from the torsional energy storage (9) via the rotatable element (6) to the expelling mechanism (5), wherein the ratchet (12.4) is switchable from one position to an adjacent position by a torque transmitted from the user handle (8) to the torsional energy storage (9). The drive train (T) is adapted to dampen torque peaks visco-elastically and/or visco-frictionally.