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公开(公告)号：US20060269480A1
公开(公告)日：2006-11-30
申请号：US11443107
申请日：2006-05-31
Applicant: Roey Amir , Doron Shabat
Inventor： Roey Amir , Doron Shabat
IPC: A61K51/00 , A61K31/787 , C08G69/00
CPC classification number: A61K31/787 , A61K47/555 , A61K47/67 , A61K47/6899 , B82Y5/00
Abstract: Novel self-immolative dendritic compounds which have a plurality of cleavable trigger units and hence can release a chemical moiety at their focal point upon a multi-triggering mechanism are disclosed. The novel self-immolative dendritic compounds are gated by a molecular logic gate, being either an AND or OR logic gate and hence can be beneficially used in a variety of biological, chemical and physical applications. Processes of preparing, compositions containing and methods utilizing the novel dendritic compounds are further disclosed.
Abstract translation: 公开了具有多个可裂解触发单元并因此可以在多重触发机制下在其焦点释放化学部分的新型自褪色树枝状化合物。 新型自褪色树枝状化合物由分子逻辑门选通，或者是或逻辑门，因此可以有益地用于各种生物，化学和物理应用。 进一步公开了制备方法，含有组合物和利用新型树枝状化合物的方法。
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2.发明申请Self-immolative dendrimers releasing many active moieties upon a single activating event 审中-公开自发性树枝状大分子在单一活化事件发生许多活性部分公开(公告)号：US20050271615A1
公开(公告)日：2005-12-08
申请号：US10525951
申请日：2003-08-28
Applicant: Doron Shabat , Benjamin List , Roey Amir , Marina Shamis , Neta Pessah
Inventor： Doron Shabat , Benjamin List , Roey Amir , Marina Shamis , Neta Pessah
IPC: A61K31/785 , A61K47/48 , C08G83/00 , C08L77/06
CPC classification number: C08G83/003 , A61K47/6949 , B82Y5/00
Abstract: A self-immolative dendrimer capable of releasing all of its tail units upon a single cleavage event, methods of synthesizing same and uses thereof are disclosed.
Abstract translation: 公开了能够在单次切割事件时释放其所有尾部单元的自褪色树枝状大分子，其合成方法及其用途。
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公开(公告)号：US06268488B1
公开(公告)日：2001-07-31
申请号：US09318661
申请日：1999-05-25
Applicant: Carlos F. Barbas, III , Doron Shabat , Christoph Rader , Benjamin List , Richard A. Lerner
Inventor： Carlos F. Barbas, III , Doron Shabat , Christoph Rader , Benjamin List , Richard A. Lerner
IPC: C07H1524
CPC classification number: C07H15/252
Abstract: The present invention provides a compound that includes an active therapeutic agent attached to a blocking moiety that is sensitive to the catalytic action of molecules having retro-aldol and retro-Michael catalytic activity, methods for making such compounds and methods of converting such compounds to active therapeutic agents using molecules having aldolase activity.
Abstract translation: 本发明提供了一种化合物，其包含与对具有后 - 醛醇缩合反应的分子的催化作用敏感的阻断部分连接的活性治疗剂和复合迈克尔催化活性，制备这种化合物的方法和将这些化合物转化为活性的方法 使用具有醛缩酶活性的分子的治疗剂。
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公开(公告)号：US07985573B2
公开(公告)日：2011-07-26
申请号：US11850942
申请日：2007-09-06
Applicant: Iftach Yacoby , Eliora Z. Ron , Doron Shabat , Marina Shamis , Itai Benhar
Inventor： Iftach Yacoby , Eliora Z. Ron , Doron Shabat , Marina Shamis , Itai Benhar
CPC classification number: A61K47/62
Abstract: The present invention relates to the field of drug delivery. More specifically, the invention relates to the preparation and use of a bacteriophage conjugated through a labile/non labile linker or directly to at least 1,000 therapeutic drug molecules such that the drug molecules are conjugated to the outer surface of the bacteriophage. The bacteriophage optionally displays on its coat a ligand that endows it with specificity towards target cells. Thus, there is provided a targeted, high-capacity drug delivery system useful for the treatment of various pathological conditions.
Abstract translation: 本发明涉及药物递送领域。 更具体地，本发明涉及通过不稳定/非不稳定接头缀合的或直接与至少1,000种治疗性药物分子结合的噬菌体的制备和用途，使得药物分子与噬菌体的外表面缀合。 噬菌体任选地在其外壳上显示赋予其对靶细胞特异性的配体。 因此，提供了可用于治疗各种病理状况的靶向高容量药物递送系统。
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Patent Agency Ranking
公开(公告)号：US06677435B2
公开(公告)日：2004-01-13
申请号：US09883758
申请日：2001-06-18
Applicant: Carlos F. Barbas, III , Doron Shabat , Christoph Rader , Benjamin List , Richard A. Lerner
Inventor： Carlos F. Barbas, III , Doron Shabat , Christoph Rader , Benjamin List , Richard A. Lerner
IPC: C07K1600
CPC classification number: C07H15/252
Abstract: The present invention provides a compound that includes an active therapeutic agent attached to a blocking moiety that is sensitive to the catalytic action of molecules having retro-aldol and retro-Michael catalytic activity, methods for making such compounds and methods of converting such compounds to active therapeutic agents using molecules having aldolase activity.
Abstract translation: 本发明提供了一种化合物，其包含与对具有后 - 醛醇缩合反应的分子的催化作用敏感的阻断部分连接的活性治疗剂和复合迈克尔催化活性，制备这种化合物的方法和将这些化合物转化为活性 使用具有醛缩酶活性的分子的治疗剂。
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公开(公告)号：US20110286971A1
公开(公告)日：2011-11-24
申请号：US13159171
申请日：2011-06-13
Applicant: Iftach YACOBY , Eliora Z. Ron , Doron Shabat , Marina Shamis , Itai Benhar
Inventor： Iftach YACOBY , Eliora Z. Ron , Doron Shabat , Marina Shamis , Itai Benhar
IPC: A61K35/76 , C12N7/01 , A61P31/10 , A61P37/06 , A61P31/12 , A61P33/00 , A61P9/10 , A61P35/00 , C12N7/00 , A61P31/04
CPC classification number: A61K47/62
Abstract: The present invention relates to the field of drug delivery. More specifically, the invention relates to the preparation and use of a bacteriophage conjugated through a labile/non labile linker or directly to at least 1,000 therapeutic drug molecules such that the drug molecules are conjugated to the outer surface of the bacteriophage. The bacteriophage optionally displays on its coat a ligand that endows it with specificity towards target cells. Thus, there is provided a targeted, high-capacity drug delivery system useful for the treatment of various pathological conditions.
Abstract translation: 本发明涉及药物递送领域。 更具体地，本发明涉及通过不稳定/非不稳定接头缀合的或直接与至少1,000种治疗性药物分子结合的噬菌体的制备和用途，使得药物分子与噬菌体的外表面缀合。 噬菌体任选地在其外壳上显示赋予其对靶细胞特异性的配体。 因此，提供了可用于治疗各种病理状况的靶向高容量药物递送系统。
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7.发明申请CONJUGATES OF A POLYMER, A BISPHOSPHONATE AND AN ANTI-ANGIOGENESIS AGENT AND USES THEREOF IN THE TREATMENT AND MONITORING OF BONE RELATED DISEASES 有权聚合物，二磷酸盐和抗血管生成剂的联合及其在骨相关疾病的治疗和监测中的应用公开(公告)号：US20110142764A1
公开(公告)日：2011-06-16
申请号：US12993856
申请日：2009-05-21
Applicant: Ronit Satchi-Fainaro , Keren Miller , Doron Shabat , Rotem Erez
Inventor： Ronit Satchi-Fainaro , Keren Miller , Doron Shabat , Rotem Erez
IPC: A61K31/785 , C08F8/40 , A61K49/00 , A61P35/00
CPC classification number: A61K47/48084 , A61K9/1676 , A61K31/337 , A61K47/548 , A61K47/58 , A61K47/65 , A61K49/0017 , A61K49/0054 , A61K2800/57 , C07F9/3873 , C07F9/65517 , C07F9/65586 , C07K5/06078 , C07K5/1008
Abstract: Conjugates of polymers or copolymers having attached thereto an anti-angiogenesis agent and a bisphosphonate bone targeting agent, and processes of preparing same, are disclosed.Pharmaceutical compositions containing these conjugates and uses thereof in the treatment of bone related disorders are also disclosed.
Abstract translation: 公开了与其连接有抗血管生成剂和双膦酸盐骨靶向剂的聚合物或共聚物的缀合物及其制备方法。 还公开了含有这些缀合物的药物组合物及其在治疗骨相关疾病中的用途。
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公开(公告)号：US20080057038A1
公开(公告)日：2008-03-06
申请号：US11850942
申请日：2007-09-06
Applicant: Iftach Yacoby , Eliora Ron , Doron Shabat , Marina Shamis , Itai Benhar
Inventor： Iftach Yacoby , Eliora Ron , Doron Shabat , Marina Shamis , Itai Benhar
CPC classification number: A61K47/62
Abstract: The present invention relates to the field of drug delivery. More specifically, the invention relates to the preparation and use of a bacteriophage conjugated through a labile/non labile linker or directly to at least 1,000 therapeutic drug molecules such that the drug molecules are conjugated to the outer surface of the bacteriophage. The bacteriophage optionally displays on its coat a ligand that endows it with specificity towards target cells. Thus, there is provided a targeted, high-capacity drug delivery system useful for the treatment of various pathological conditions.
Abstract translation: 本发明涉及药物递送领域。 更具体地，本发明涉及通过不稳定/非不稳定接头缀合的或直接与至少1,000种治疗性药物分子结合的噬菌体的制备和用途，使得药物分子与噬菌体的外表面缀合。 噬菌体任选地在其外壳上显示赋予其对靶细胞特异性的配体。 因此，提供了可用于治疗各种病理状况的靶向高容量药物递送系统。
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9.发明授权Conjugates of a polymer, a bisphosphonate and an anti-angiogenesis agent and uses thereof in the treatment and monitoring of bone related diseases 有权聚合物，双膦酸盐和抗血管生成剂的结合物及其在治疗和监测骨相关疾病中的用途公开(公告)号：US08658149B2
公开(公告)日：2014-02-25
申请号：US12993856
申请日：2009-05-21
Applicant: Ronit Satchi-Fainaro , Keren Miller , Doron Shabat , Rotem Erez
Inventor： Ronit Satchi-Fainaro , Keren Miller , Doron Shabat , Rotem Erez
IPC: A61K31/74
CPC classification number: A61K47/48084 , A61K9/1676 , A61K31/337 , A61K47/548 , A61K47/58 , A61K47/65 , A61K49/0017 , A61K49/0054 , A61K2800/57 , C07F9/3873 , C07F9/65517 , C07F9/65586 , C07K5/06078 , C07K5/1008
Abstract: Conjugates of polymers or copolymers having attached thereto an anti-angiogenesis agent and a bisphosphonate bone targeting agent, and processes of preparing same, are disclosed.Pharmaceutical compositions containing these conjugates and uses thereof in the treatment of bone related disorders are also disclosed.
Abstract translation: 公开了与其连接有抗血管生成剂和双膦酸盐骨靶向剂的聚合物或共聚物的缀合物及其制备方法。 还公开了含有这些缀合物的药物组合物及其在治疗骨相关疾病中的用途。
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