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    NOVEL FLUORINE-CONTAINING BISPHOSPHONIC ACID DERIVATIVE AND USE THEREOF
    5.
    发明申请
    NOVEL FLUORINE-CONTAINING BISPHOSPHONIC ACID DERIVATIVE AND USE THEREOF 审中-公开

    公开(公告)号：US20180022769A1

    公开(公告)日：2018-01-25

    申请号：US15548303

    申请日：2016-02-01

    申请人： NAGASAKI UNIVERSITY

    发明人： Yoshimasa TANAKA ,  Satoshi MIZUTA ,  Hiroshi UEDA

    IPC分类号： C07F9/6506 ,  A61K35/17 ,  A61K31/683

    CPC分类号： C07F9/6506 ,  A61K31/683 ,  A61K35/17 ,  C07F9/3873

    摘要： A series of fluorine-containing bisphosphonic acids in which an alkylamine side chain is added, a series of fluorine-containing bisphosphonic acids in which an amino group substituted by a heterocyclic group or a heterocyclic group containing a nitrogen atom is added, to the carbon atom of P—C(F)—P, and a series of fluorine-containing bisphosphonate derivatives in which the acid moiety thereof is esterified by an alkoxymethyl group such as POM group, n-butanoyloxymethyl (BuOM) group and the like, that is, the fluorine-containing bisphosphonic acid and fluorine-containing bisphosphonate derivative represented by the following formula (I): wherein each symbol is as defined in the DESCRIPTION, can efficiently induce proliferation of peripheral blood γδ T cells that express Vγ2Vδ2 T cell receptor having superior cytotoxicity against tumor cells and virus infected cells, immunize tumor cells and virus infected cells, and can induce cytotoxicity by γδ T cells.

    PRODUCTION PROCESS FOR SELF-DISPERSIBLE PIGMENT, SELF-DISPERSIBLE PIGMENT, INK, INK CARTRIDGE AND INK JET RECORDING METHOD
    9.
    发明申请
    PRODUCTION PROCESS FOR SELF-DISPERSIBLE PIGMENT, SELF-DISPERSIBLE PIGMENT, INK, INK CARTRIDGE AND INK JET RECORDING METHOD 有权
    自分散颜料的生产工艺，自分散颜料，墨水，墨盒和喷墨记录方法

    公开(公告)号：US20150376426A1

    公开(公告)日：2015-12-31

    申请号：US14747343

    申请日：2015-06-23

    申请人： CANON KABUSHIKI KAISHA

    发明人： Taiki Watanabe ,  Koichi Suzuki ,  Ryuji Higashi ,  Masashi Hirose

    IPC分类号： C09D11/322 ,  C07F9/38 ,  C07D471/04 ,  C07C241/02 ,  C07F1/08

    CPC分类号： C09D11/322 ,  B41J2/01 ,  C07C241/02 ,  C07D471/04 ,  C07F9/3834 ,  C07F9/3873 ,  C09D11/324

    摘要： The invention provides a production process for a self-dispersible pigment, having a step of bonding a group R1 in the following general formula (1) to a particle surface of a pigment by radical addition reaction induced by removal of a hydrogen atom from a compound represented by the general formula (1): HN═N—R1   (1) wherein R1 is a group having at least one of an aliphatic group and an aromatic group and being substituted with at least one hydrophilic group selected from the group consisting of a carboxylic acid group, a sulfonic acid group, a phosphoric acid group and a phosphoric acid group.

    摘要翻译： 本发明提供了一种自分散性颜料的制造方法，其具有以下通式（1）中的基团R1与颜料的粒子表面接合的步骤，通过从化合物中除去氢原子而引起的自由基加成反应 由通式（1）表示：HN = N-R1（1）其中R1是具有至少一个脂族基团和芳族基团并且被至少一个选自以下的亲水基团取代的基团： 羧酸基，磺酸基，磷酸基和磷酸基。