公开(公告)号：US10364262B2

公开(公告)日：2019-07-30

申请号：US14415684

申请日：2013-07-17

申请人： MONSANTO TECHNOLOGY LLC

发明人： Albert Devaux ,  Sebastian Burck ,  Patrick Notte

IPC分类号： C07F9/38

摘要： A method for synthesis of N-phosphonoalkyliminodiacetic acid or derivatives thereof by forming a reaction mixture having an acid catalyst, a compound of the following general formula R1—CH2—NX—CH2—R2 and a compound having one or more P—O—P anhydride moieties to form a compound having a formula R1—CH2—N(—CH2PO3R32)(—CH2—R2) wherein in R1—CH2—NX—CH2—R2: X is —CH2—OH or —CH2—COOH; R1 and R2 are independently selected from the group consisting of nitrile, C1-C4 alkyl carboxylate, and carboxylic acid for when X is —CH2—OH, or R1 and R2 are both carbonyl groups linked by a hydrogen substituted nitrogen atom or a C1-C4-alkyl substituted nitrogen atom; and R3 is H, an alkyl group, or an aryl group; the anhydride moieties in the P—O—P anhydride compound have one P atom at the oxidation state (+III) and one P atom at the oxidation state (+III) or (+V); and 2) hydrolyzing the mixture to form N-phosphonomethyliminodiacetic acid or one of its derivatives.

公开(公告)号：US20180346497A1

公开(公告)日：2018-12-06

申请号：US15848219

申请日：2017-12-20

申请人： Monsanto Technology LLC

发明人： Patrick Notte ,  Samuel Cogels ,  Sebastian Burck

IPC分类号： C07F9/6533 ,  C07F9/572 ,  C07F9/38

CPC分类号： C07F9/6533 ,  C07F9/3808 ,  C07F9/3813 ,  C07F9/3873 ,  C07F9/3886 ,  C07F9/572 ,  C07F9/5728 ,  C07F9/6524

摘要： The present invention is related to a new method for the synthesis of alpha-aminoalkylenephosphonic acid or its phosphonate esters comprising the steps of forming a reaction mixture by mixing a P—O—P anhydride moiety comprising compound, having one P-atom at the oxidation state (+III) and the other P-atom at the oxidation state (+III) or (+V), an aminoalkanecarboxylic acid and an acid catalyst, wherein said reaction mixture comprises an equivalent ratio of alpha-aminoalkylene carboxylic acid to P—O—P anhydride moieties of at least 0.2, and recovering the resulting alpha-aminoalkylene phosphonic acid compound or an ester thereof from the reaction mixture.

公开(公告)号：US10464958B2

公开(公告)日：2019-11-05

申请号：US15848219

申请日：2017-12-20

申请人： Monsanto Technology LLC

发明人： Patrick Notte ,  Samuel Cogels ,  Sebastian Burck

IPC分类号： C07F9/6533 ,  C07F9/572 ,  C07F9/6524 ,  C07F9/38

摘要： The present invention is related to a new method for the synthesis of alpha-aminoalkylenephosphonic acid or its phosphonate esters comprising the steps of forming a reaction mixture by mixing a P—O—P anhydride moiety comprising compound, having one P-atom at the oxidation state (+III) and the other P-atom at the oxidation state (+III) or (+V), an aminoalkanecarboxylic acid and an acid catalyst, wherein said reaction mixture comprises an equivalent ratio of alpha-aminoalkylene carboxylic acid to P—O—P anhydride moieties of at least 0.2, and recovering the resulting alpha-aminoalkylene phosphonic acid compound or an ester thereof from the reaction mixture.

公开(公告)号：US10280189B2

公开(公告)日：2019-05-07

申请号：US14415686

申请日：2013-07-17

申请人： MONSANTO TECHNOLOGY LLC

发明人： Sebastian Burck ,  Cedric Nicolas Leclercq ,  Patrick Notte

IPC分类号： C07F9/653 ,  C07F9/6533 ,  C07F9/572 ,  C07F9/6506 ,  C07F9/38

摘要： A method for the synthesis of an aminoalkylenephosphonic acid or its phosphonate esters including the following steps: a) forming, in the presence of an aldehyde or ketone and an acid catalyst, a reaction mixture by mixing a compound having at least one HNR1R2 moiety or a salt thereof, with a compound having one or more P—O—P anhydride moieties, the moieties having one P atom at the oxidation state (+III) and one P atom at the oxidation state (+III) or (+V), wherein the ratio of moles of aldehyde or ketone to N—H moieties is 1 or more and wherein the ratio of N—H moieties to P—O—P anhydride moieties is 0.3 or more, and b) recovering the resulting aminoalkylenephosphonic acid having compound or its phosphonate esters.