Invention Grant
- Patent Title: Prodrug activation using catalytic antibodies
- Patent Title (中): 使用催化抗体进行前药活化
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Application No.: US09883758Application Date: 2001-06-18
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Publication No.: US06677435B2Publication Date: 2004-01-13
- Inventor: Carlos F. Barbas, III , Doron Shabat , Christoph Rader , Benjamin List , Richard A. Lerner
- Applicant: Carlos F. Barbas, III , Doron Shabat , Christoph Rader , Benjamin List , Richard A. Lerner
- Main IPC: C07K1600
- IPC: C07K1600
Abstract:
The present invention provides a compound that includes an active therapeutic agent attached to a blocking moiety that is sensitive to the catalytic action of molecules having retro-aldol and retro-Michael catalytic activity, methods for making such compounds and methods of converting such compounds to active therapeutic agents using molecules having aldolase activity.
Public/Granted literature
- US20020058804A1 Prodrug activation using catalytic antibodies Public/Granted day:2002-05-16
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