公开(公告)号：US20230249144A1

公开(公告)日：2023-08-10

申请号：US18137677

申请日：2023-04-21

Applicant: Roche Molecular Systems, Inc.

Inventor： Patrick Birkner ,  Manfred Holzer ,  Pirmin Hans Loetscher ,  Ulf Nilsson

IPC: B01F31/80 ,  C12N13/00 ,  G01N1/28 ,  B01J19/10 ,  B01F35/42

CPC classification number: B01F31/80 ,  C12N13/00 ,  G01N1/286 ,  B01J19/10 ,  B01F35/42 ,  B06B1/0611

Abstract: The present disclosure relates to a device for sonicating a biological sample. In one embodiment, a sample tube holder is pivotally suspended in a mount of a sonication device, thus allowing for a rotational degree of freedom and/or lateral movement that provides an optimized contact area between the sonotrode and the sample tube. Also disclosed is a method for sonicating a biological sample using the device described herein.

公开(公告)号：US20190308147A1

公开(公告)日：2019-10-10

申请号：US16376286

申请日：2019-04-05

Applicant: Roche Molecular Systems, Inc.

Inventor： Patrick Birkner ,  Manfred Holzer ,  Pirmin Hans Loetscher ,  Ulf Nilsson

IPC: B01F11/02 ,  G01N1/28 ,  C12N13/00 ,  B01F15/00

Abstract: The present disclosure relates to a device for sonicating a biological sample. In one embodiment, a sample tube holder is pivotally suspended in a mount of a sonication device, thus allowing for a rotational degree of freedom and/or lateral movement that provides an optimized contact area between the sonotrode and the sample tube. Also disclosed is a method for sonicating a biological sample using the device described herein.

公开(公告)号：US20240230329A9

公开(公告)日：2024-07-11

申请号：US18491622

申请日：2023-10-20

Applicant: Roche Molecular Systems, Inc.

Inventor： Patrick Birkner ,  Raphael Gut

IPC: G01C9/02 ,  B01L3/00

CPC classification number: G01C9/02 ,  B01L3/502715 ,  B01L2200/14 ,  B01L2300/0645 ,  B01L2300/0663

Abstract: A laboratory instrument for processing a sample is proposed. The laboratory instrument comprises at least one level sensor configured for generating at least one level signal. The laboratory instrument further comprises at least one evaluation and control unit configured for evaluating the level signal thereby determining at least one item of tilt information on the laboratory instrument. The evaluation and control unit is further configured for determining at least one change in the level signal thereby detecting interfering influences on the laboratory instrument.

公开(公告)号：US20240133688A1

公开(公告)日：2024-04-25

申请号：US18491622

申请日：2023-10-19

Applicant: Roche Molecular Systems, Inc.

Inventor： Patrick Birkner ,  Raphael Gut

IPC: G01C9/02 ,  B01L3/00

CPC classification number: G01C9/02 ,  B01L3/502715 ,  B01L2200/14 ,  B01L2300/0645 ,  B01L2300/0663

Abstract: A laboratory instrument for processing a sample is proposed. The laboratory instrument comprises at least one level sensor configured for generating at least one level signal. The laboratory instrument further comprises at least one evaluation and control unit configured for evaluating the level signal thereby determining at least one item of tilt information on the laboratory instrument. The evaluation and control unit is further configured for determining at least one change in the level signal thereby detecting interfering influences on the laboratory instrument.

公开(公告)号：US11666873B2

公开(公告)日：2023-06-06

申请号：US16376286

申请日：2019-04-05

Applicant: Roche Molecular Systems, Inc.

Inventor： Patrick Birkner ,  Manfred Holzer ,  Pirmin Hans Loetscher ,  Ulf Nilsson

IPC: G01N1/28 ,  B01F31/80 ,  C12N13/00 ,  B01J19/10 ,  B01F35/42 ,  B06B1/06 ,  B01F101/23

CPC classification number: B01F31/80 ,  B01F35/42 ,  B01J19/10 ,  C12N13/00 ,  G01N1/286 ,  B01F2101/23 ,  B06B1/0611

Abstract: The present disclosure relates to a device for sonicating a biological sample. In one embodiment, a sample tube holder is pivotally suspended in a mount of a sonication device, thus allowing for a rotational degree of freedom and/or lateral movement that provides an optimized contact area between the sonotrode and the sample tube. Also disclosed is a method for sonicating a biological sample using the device described herein.

公开(公告)号：US20230152342A1

公开(公告)日：2023-05-18

申请号：US18056626

申请日：2022-11-17

Applicant: Roche Molecular Systems, Inc.

Inventor： Raphael Gut ,  Pius Hermann ,  Alexander Meier ,  Patrick Birkner ,  Christian Ettel ,  Roger Spescha ,  Pengfei Wang ,  Simon Durrer

IPC: G01N35/10 ,  G01L5/00 ,  G01L1/20

CPC classification number: G01N35/1011 ,  G01L1/20 ,  G01L5/0038

Abstract: A method for detection of a bottom of a well of a multiwell plate for a pipetting device is disclosed. The pipetting device includes a pipetting head configured for being coupled to a plurality of pipetting tips. A force sensor configured for measuring a resistance force depending on a force on a pipetting tip exerted by the bottom is used. The method includes measuring the resistance force during movement of one of the pipetting tips from a start position downstream towards the bottom of the well and stopping the movement at a bottom position. The method further includes storing the bottom position together with a corresponding logical position of the well in the multiwell plate in a database. Further disclosed is a pipetting device, a laboratory instrument for processing and/or analyzing a sample and a computer program and a computer-readable storage medium for performing the method.