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公开(公告)号：US20220268796A1
公开(公告)日：2022-08-25
申请号：US17179835
申请日：2021-02-19
Applicant: Roche Molecular Systems, Inc.
Inventor： Eveline Bachmair , Andreas Gisler , Raphael Gut , Alejandro Hernandez , Alexander Meier
Abstract: Disclosed is a method and laboratory instrument aimed at reducing the loss of time of liquid level determination each time a liquid container is loaded into an instrument and at the same time reducing waste of liquid containers due to unforeseen changes in the liquid levels by combining a fast liquid level check at an expected liquid level with a liquid level search if no liquid level is found at the expected level, while also ensuring proper liquid aspiration as the liquid level is always verified (expected level is not blindly relied upon).
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公开(公告)号：US10967370B2
公开(公告)日：2021-04-06
申请号：US15719394
申请日：2017-09-28
Applicant: Roche Molecular Systems, Inc.
Inventor： Alexander Meier , Chris Steinert , Michael Zeder
Abstract: The present disclosure provides a microfluidic device (1) comprising at least one flow channel (21) connecting an inlet opening (22) with an outlet opening (23), and an array of wells (24) in fluid communication with the flow channel (21), wherein the flow channel (21) comprises an inlet portion (211) at the inlet opening (22), an outlet portion (212) at the outlet opening (23), and a middle portion (213) between the inlet portion (211) and the outlet portion (212), wherein at least the middle portion (213) comprises the array of wells (24) and is provided with a hydrophilic surface, and the flow channel (21) further comprises a transition area (214) provided at least between the middle portion (213) and the outlet portion (212), which transition area (214) is constituted by providing a hydrophobic surface. Furthermore, a method for manufacturing such a microfluidic device is also provided.
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公开(公告)号：US20200306753A1
公开(公告)日：2020-10-01
申请号：US16833247
申请日：2020-03-27
Applicant: Roche Molecular Systems, Inc.
Inventor： Alexander Meier , Chris Steinert , Michael Zeder
Abstract: A microfluidic device for thermocycling of a reaction mixture is provided. The device comprises an inlet opening, an outlet opening, a flow channel connecting the inlet opening and the outlet opening and defining a flow direction from the inlet opening through the flow channel to the outlet opening, wherein the flow channel comprises a first flow channel surface and a second flow channel surface opposite to the first flow channel surface, and an array of wells provided in the first flow channel surface for fluidic communication with the inlet opening and the outlet opening. Further, the first flow channel surface provides a first hydrophilicity and at least a part of the second flow channel surface provides a second hydrophilicity, wherein the first hydrophilicity is greater than the second hydrophilicity.
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公开(公告)号：US12005439B2
公开(公告)日：2024-06-11
申请号：US16833247
申请日：2020-03-27
Applicant: Roche Molecular Systems, Inc.
Inventor： Alexander Meier , Chris Steinert , Michael Zeder
CPC classification number: B01L3/502707 , B01L7/52 , B01L2200/02 , B01L2200/12 , B01L2300/041 , B01L2300/0816 , B01L2300/12 , B01L2300/161 , B01L2300/168 , B01L2300/18
Abstract: A microfluidic device for thermocycling of a reaction mixture is provided. The device comprises an inlet opening, an outlet opening, a flow channel connecting the inlet opening and the outlet opening and defining a flow direction from the inlet opening through the flow channel to the outlet opening, wherein the flow channel comprises a first flow channel surface and a second flow channel surface opposite to the first flow channel surface, and an array of wells provided in the first flow channel surface for fluidic communication with the inlet opening and the outlet opening. Further, the first flow channel surface provides a first hydrophilicity and at least a part of the second flow channel surface provides a second hydrophilicity, wherein the first hydrophilicity is greater than the second hydrophilicity.
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公开(公告)号：US20230258676A1
公开(公告)日：2023-08-17
申请号：US18056601
申请日：2022-11-17
Applicant: Roche Molecular Systems, Inc.
Inventor： Fabian Baggio , Roman Egli , Christian Ettel , Raphael Gut , Pius Hermann , Nikifor Korjagin , Alexander Meier , Thomas Schlaubitz , Rolf Schneebeli , Simon Siegenthaler , Ivo Daniel Vicente Leitao , Stefan Vollenweider
CPC classification number: G01N35/04 , G01N35/00732 , G01N2035/0412
Abstract: A method for introducing a sample rack holding a plurality of sample receptacles into a receiving bay in a housing of an automated analytical system is disclosed. The method is carried out by manually moving the sample rack from a loading position towards a processing position along a lane in the receiving bay, pausing the movement when the rack reaches a focusing position, moving a reader to focuse onto the lane, resuming the movement of the sample rack and detecting features of the sample rack during the movement, positioning, detecting, and locking the sample rack in the processing position, and processing the content of the sample receptacles.
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Patent Agency Ranking
公开(公告)号：US20250020683A1
公开(公告)日：2025-01-16
申请号：US18711362
申请日：2022-11-16
Applicant: Roche Molecular Systems, Inc.
Inventor： Christian Ettel , Alan Furlan , Alexander Meier
IPC: G01N35/10
Abstract: A method for controlling a laboratory system or device comprising at least one pipettor with a pressure sensor, at least one humidity sensor, at least one temperature sensor, and a control unit. The control unit receiving a humidity value from the humidity sensor and a temperature value from the temperature sensor, comparing the pair of humidity and temperature values with a threshold database connected to the control unit, the threshold database comprising, for different pairs of humidity and temperature values, instructions to activate or deactivate an anti droplet control system of the pipettor, determining if the anti droplet system of the pipettor has to be activated or deactivated, activating or deactivating said anti droplet system of the pipettor.
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公开(公告)号：US20250012827A1
公开(公告)日：2025-01-09
申请号：US18711496
申请日：2022-11-17
Applicant: Roche Molecular Systems, Inc.
Inventor： Federico Dalcanale , Simon Goudie , David Hradetzky , Dagmar Wanda Lewandowska , Alexander Meier , Sabrina Zgraggen
IPC: G01N35/10
Abstract: A method for controlling an anti droplet system of a laboratory system or device comprising at least one air displacement pipettor with a pressure sensor and a control unit for controlling operation of the pipettor, the method comprising the following steps controlling the pipettor to be moved such that the pipettor tip is immerged in a fluid to be aspirated, aspirate a predetermined volume of fluid, move the pipettor such that the pipettor tip is emerged from the fluid, continuously monitoring the pressure above the fluid column in the pipettor tip and generating pressure curve over time, and determining if a pressure increase above the fluid column has been detected.
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公开(公告)号：US20240390889A1
公开(公告)日：2024-11-28
申请号：US18665277
申请日：2024-05-15
Applicant: Roche Molecular Systems, Inc.
Inventor： Alexander Meier , Chris Steinert , Michael Zeder
Abstract: A microfluidic device for thermocycling of a reaction mixture is provided. The device comprises an inlet opening, an outlet opening, a flow channel connecting the inlet opening and the outlet opening and defining a flow direction from the inlet opening through the flow channel to the outlet opening, wherein the flow channel comprises a first flow channel surface and a second flow channel surface opposite to the first flow channel surface, and an array of wells provided in the first flow channel surface for fluidic communication with the inlet opening and the outlet opening. Further, the first flow channel surface provides a first hydrophilicity and at least a part of the second flow channel surface provides a second hydrophilicity, wherein the first hydrophilicity is greater than the second hydrophilicity.
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公开(公告)号：US20230152343A1
公开(公告)日：2023-05-18
申请号：US18056425
申请日：2022-11-17
Applicant: Roche Molecular Systems, Inc.
Inventor： Raphael Gut , Alexander Meier
CPC classification number: G01N35/1072 , B01L3/021 , G01N2035/1025
Abstract: A laboratory instrument for processing a sample and a method for automatic surveillance of at least one pipetting procedure of at least one laboratory instrument for processing a sample are disclosed. The laboratory instrument includes at least one pipetting device with at least one pipetting head configured for being coupled to a plurality of pipetting tips. The laboratory instrument further includes a compartment configured for receiving, storing, and/or releasing at least one sample holder. The pipetting device is configured for performing at least one pipetting procedure on the sample holder and the laboratory instrument includes at least one sensor unit configured for gravimetric measuring of the sample holder.
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公开(公告)号：US20230152342A1
公开(公告)日：2023-05-18
申请号：US18056626
申请日：2022-11-17
Applicant: Roche Molecular Systems, Inc.
Inventor： Raphael Gut , Pius Hermann , Alexander Meier , Patrick Birkner , Christian Ettel , Roger Spescha , Pengfei Wang , Simon Durrer
CPC classification number: G01N35/1011 , G01L1/20 , G01L5/0038
Abstract: A method for detection of a bottom of a well of a multiwell plate for a pipetting device is disclosed. The pipetting device includes a pipetting head configured for being coupled to a plurality of pipetting tips. A force sensor configured for measuring a resistance force depending on a force on a pipetting tip exerted by the bottom is used. The method includes measuring the resistance force during movement of one of the pipetting tips from a start position downstream towards the bottom of the well and stopping the movement at a bottom position. The method further includes storing the bottom position together with a corresponding logical position of the well in the multiwell plate in a database. Further disclosed is a pipetting device, a laboratory instrument for processing and/or analyzing a sample and a computer program and a computer-readable storage medium for performing the method.
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