公开(公告)号：US12214219B2

公开(公告)日：2025-02-04

申请号：US18295448

申请日：2023-04-04

Applicant: RefleXion Medical, Inc.

Inventor： Michael Kirk Owens ,  Rostem Bassalow ,  Peter Demetri Olcott ,  Yevgen Voronenko ,  David Quentin Larkin ,  Samuel Mazin

IPC: A61N5/10 ,  A61B6/00 ,  A61B6/03

Abstract: Disclosed herein are systems and methods for adapting and/or updating radiotherapy treatment plans based on biological and/or physiological data and/or anatomical data extracted or calculated from imaging data acquired in real-time (e.g., during a treatment session). Functional imaging data acquired at the time of radiation treatment is used to modify a treatment plan and/or dose delivery instructions to provide a prescribed dose distribution to patient target regions. Also disclosed herein are methods for evaluating treatment plans based on imaging data acquired in real-time.

公开(公告)号：US12115386B2

公开(公告)日：2024-10-15

申请号：US17571273

申请日：2022-01-07

Applicant: RefleXion Medical, Inc.

Inventor： Yevgen Voronenko ,  Debashish Pal ,  David Quentin Larkin ,  George Zdasiuk ,  Jayakrishnan Janardhanan ,  Michael Kirk Owens ,  Peter Demetri Olcott

IPC: A61N5/10

CPC classification number: A61N5/1031 ,  A61N5/1039 ,  A61N5/1043 ,  A61N5/1045 ,  A61N5/1084

Abstract: Disclosed herein are methods for patient setup and patient target region localization for the irradiation of multiple patient target regions in a single treatment session. Virtual localization is a method that can be used to register a patient target region without requiring that the patient is physically moved using the patient platform. Instead, the planned fluence is updated to reflect the current location of the patient target region by selecting a localization reference in the localization image, calculating a localization function based on the localization reference point, and calculating the delivery fluence by convolving the localization function with a shift-invariant firing filter. Mosaic multi-target localization partitions a planned fluence map for multiple patient target regions into sub-regions that can be individually localized. De-coupled multi-target localization involves generating a separate planned fluence map for each target but constraining a cumulative fluence map to ensure dosimetric goals are met.

公开(公告)号：US12090340B2

公开(公告)日：2024-09-17

申请号：US17696662

申请日：2022-03-16

Applicant: RefleXion Medical, Inc.

Inventor： Brent Harper ,  David Quentin Larkin ,  Peter Demetri Olcott ,  George Andrew Zdasiuk ,  David Nett ,  Victor Carboni

IPC: A61N5/10 ,  H05H9/00

CPC classification number: A61N5/1048 ,  A61N5/1045 ,  A61N5/1081 ,  A61N5/1083 ,  H05H9/00 ,  H05H2277/11

Abstract: Disclosed herein are systems and methods for rapidly delivering high doses of radiation, also known as, flash dose radiotherapy or flash radiotherapy. One variation of a system for flash radiotherapy has a plurality of therapeutic radiation sources on a support structure (e.g., a gantry or arm) and configured to toward a patient target region, and a controller in communication with all of the therapeutic radiation sources. The controller is configured to activate the plurality of therapeutic radiation sources simultaneously so that the patient target region rapidly receives a high dose of radiation, e.g. the entire prescribed dose of radiation. In some variations, a flash radiotherapy system has a pulsed, high-power source that may be used to generate an X-ray pulse that delivers a dose having a dose rate from about 7.5 Gy/s to about 70 Gy/s. Flash radiotherapy systems may also include one or more imaging systems mounted on the support structure.

公开(公告)号：US11648418B2

公开(公告)日：2023-05-16

申请号：US16016272

申请日：2018-06-22

Applicant: RefleXion Medical, Inc.

Inventor： Michael Kirk Owens ,  Rostem Bassalow ,  Peter Demetri Olcott ,  Yevgen Voronenko ,  David Quentin Larkin ,  Samuel Mazin

IPC: A61N5/10

CPC classification number: A61N5/1031 ,  A61N5/1039 ,  A61N5/1049 ,  A61N5/1064 ,  A61N5/1067 ,  A61N5/1068 ,  A61N5/1036 ,  A61N5/1037 ,  A61N5/1038 ,  A61N5/1045 ,  A61N2005/1034 ,  A61N2005/1052 ,  A61N2005/1055 ,  A61N2005/1058

Abstract: Disclosed herein are systems and methods for adapting and/or updating radiotherapy treatment plans based on biological and/or physiological data and/or anatomical data extracted or calculated from imaging data acquired in real-time (e.g., during a treatment session). Functional imaging data acquired at the time of radiation treatment is used to modify a treatment plan and/or dose delivery instructions to provide a prescribed dose distribution to patient target regions. Also disclosed herein are methods for evaluating treatment plans based on imaging data acquired in real-time.