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公开(公告)号：US11406846B2
公开(公告)日：2022-08-09
申请号：US16412780
申请日：2019-05-15
Applicant: RefleXion Medical, Inc.
Inventor： Yevgen Voronenko , Rostem Bassalow , Peter Olcott , Brent Harper , David Larkin
Abstract: This application relates to methods for delivering radiation to a positron-emitting target within a subject under continuous PET guidance. Instead of directing radiation at a collinear path along each detected positron line-of-response (LOR), the methods generally include detecting a pattern of LORs that intersect the target. In response to the pattern, radiation may be delivered along paths that are not necessarily collinear to any of the LORs. Methods for further modifying radiation delivery as well as the detected LOR population are also described.
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公开(公告)号：US11675097B2
公开(公告)日：2023-06-13
申请号：US17697828
申请日：2022-03-17
Applicant: Reflexion Medical, Inc.
Inventor： Peter Demetri Olcott , Matthew Francis Bieniosek , Brent Harper
CPC classification number: G01T1/2985 , G01T1/172 , G01T1/208 , G01T1/2023 , G01T7/005
Abstract: Disclosed herein are methods and devices for the acquisition of positron emission (or PET) data in the presence of ionizing radiation that causes afterglow of PET detectors. In one variation, the method comprises adjusting a coincidence trigger threshold of the PET detectors during a therapy session. In one variation, the method comprises adjusting a gain factor used in positron emission data acquisition (e.g., a gain factor used to multiply and/or shift the output(s) of a PET detector(s)) during a therapy session. In some variations, a method for acquiring positron emission data during a radiation therapy session comprises suspending communication between the PET detectors and a signal processor of a controller for a predetermined period of time after a radiation pulse has been emitted by the linac.
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公开(公告)号：US10702715B2
公开(公告)日：2020-07-07
申请号：US15814276
申请日：2017-11-15
Applicant: RefleXion Medical, Inc.
Inventor： William Pearce , Brent Harper
IPC: A61N5/10
Abstract: Described here are systems, devices, and methods for imaging and radiotherapy procedures. Generally, a radiotherapy system may include a radiotransparent patient platform, a radiation source coupled to a multi-leaf collimator, and a detector facing the collimator. The radiation source may be configured to emit a first beam through the collimator to provide treatment to a patient on the patient platform. A controller may be configured to control the radiotherapy system.
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公开(公告)号：US11975220B2
公开(公告)日：2024-05-07
申请号：US16887852
申请日：2020-05-29
Applicant: RefleXion Medical, Inc.
Inventor： Brent Harper , David Larkin , David Nett
CPC classification number: A61N5/1081 , A61N5/1045 , A61N5/1049 , A61N2005/005 , A61N2005/1052 , A61N2005/1091 , A61N2005/1094 , G21K1/046
Abstract: Disclosed herein are radiation therapy systems and methods. These radiation therapy systems and methods are used for emission-guided radiation therapy, where gamma rays from markers or tracers that are localized to patient tumor regions are detected and used to direct radiation to the tumor. The radiation therapy systems described herein comprise a gantry comprising a rotatable ring coupled to a stationary frame via a rotating mechanism such that the rotatable ring rotates up to about 70 RPM, a radiation source (e.g., MV X-ray source) mounted on the rotatable ring, and one or more PET detectors mounted on the rotatable ring.
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公开(公告)号：US11287540B2
公开(公告)日：2022-03-29
申请号：US16887896
申请日：2020-05-29
Applicant: RefleXion Medical, Inc.
Inventor： Peter Demetri Olcott , Matthew Francis Bieniosek , Brent Harper
Abstract: Disclosed herein are methods and devices for the acquisition of positron emission (or PET) data in the presence of ionizing radiation that causes afterglow of PET detectors. In one variation, the method comprises adjusting a coincidence trigger threshold of the PET detectors during a therapy session. In one variation, the method comprises adjusting a gain factor used in positron emission data acquisition (e.g., a gain factor used to multiply and/or shift the output(s) of a PET detector(s)) during a therapy session. In some variations, a method for acquiring positron emission data during a radiation therapy session comprises suspending communication between the PET detectors and a signal processor of a controller for a predetermined period of time after a radiation pulse has been emitted by the linac.
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Patent Agency Ranking
公开(公告)号：US10695586B2
公开(公告)日：2020-06-30
申请号：US15814222
申请日：2017-11-15
Applicant: RefleXion Medical, Inc.
Inventor： Brent Harper , Robert Wiggers , David Larkin , David Meer , David Nett , Rostem Bassalow , Peter Olcott , Chris Julian , Brent Dolan , William Jorge Pearce
Abstract: Disclosed herein are radiation therapy systems and methods. These radiation therapy systems and methods are used for emission-guided radiation therapy, where gamma rays from markers or tracers that are localized to patient tumor regions are detected and used to direct radiation to the tumor. The radiation therapy systems described herein comprise a gantry comprising a rotatable ring coupled to a stationary frame via a rotating mechanism such that the rotatable ring rotates up to about 70 RPM, a radiation source (e.g., MV X-ray source) mounted on the rotatable ring, and one or more PET detectors mounted on the rotatable ring.
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公开(公告)号：US12090340B2
公开(公告)日：2024-09-17
申请号：US17696662
申请日：2022-03-16
Applicant: RefleXion Medical, Inc.
Inventor： Brent Harper , David Quentin Larkin , Peter Demetri Olcott , George Andrew Zdasiuk , David Nett , Victor Carboni
CPC classification number: A61N5/1048 , A61N5/1045 , A61N5/1081 , A61N5/1083 , H05H9/00 , H05H2277/11
Abstract: Disclosed herein are systems and methods for rapidly delivering high doses of radiation, also known as, flash dose radiotherapy or flash radiotherapy. One variation of a system for flash radiotherapy has a plurality of therapeutic radiation sources on a support structure (e.g., a gantry or arm) and configured to toward a patient target region, and a controller in communication with all of the therapeutic radiation sources. The controller is configured to activate the plurality of therapeutic radiation sources simultaneously so that the patient target region rapidly receives a high dose of radiation, e.g. the entire prescribed dose of radiation. In some variations, a flash radiotherapy system has a pulsed, high-power source that may be used to generate an X-ray pulse that delivers a dose having a dose rate from about 7.5 Gy/s to about 70 Gy/s. Flash radiotherapy systems may also include one or more imaging systems mounted on the support structure.
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公开(公告)号：US12032107B2
公开(公告)日：2024-07-09
申请号：US18311134
申请日：2023-05-02
Applicant: RefleXion Medical, Inc.
Inventor： Peter Demetri Olcott , Matthew Francis Bieniosek , Brent Harper
CPC classification number: G01T1/2985 , G01T1/172 , G01T1/2023 , G01T1/208 , G01T7/005
Abstract: Disclosed herein are methods and devices for the acquisition of positron emission (or PET) data in the presence of ionizing radiation that causes afterglow of PET detectors. In one variation, the method comprises adjusting a coincidence trigger threshold of the PET detectors during a therapy session. In one variation, the method comprises adjusting a gain factor used in positron emission data acquisition (e.g., a gain factor used to multiply and/or shift the output(s) of a PET detector(s)) during a therapy session. In some variations, a method for acquiring positron emission data during a radiation therapy session comprises suspending communication between the PET detectors and a signal processor of a controller for a predetermined period of time after a radiation pulse has been emitted by the linac.
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公开(公告)号：US20230393292A1
公开(公告)日：2023-12-07
申请号：US18311134
申请日：2023-05-02
Applicant: RefleXion Medical, Inc.
Inventor： Peter Demetri Olcott , Matthew Francis Bieniosek , Brent Harper
CPC classification number: G01T1/2985 , G01T7/005 , G01T1/2023 , G01T1/172 , G01T1/208
Abstract: Disclosed herein are methods and devices for the acquisition of positron emission (or PET) data in the presence of ionizing radiation that causes afterglow of PET detectors. In one variation, the method comprises adjusting a coincidence trigger threshold of the PET detectors during a therapy session. In one variation, the method comprises adjusting a gain factor used in positron emission data acquisition (e.g., a gain factor used to multiply and/or shift the output(s) of a PET detector(s)) during a therapy session. In some variations, a method for acquiring positron emission data during a radiation therapy session comprises suspending communication between the PET detectors and a signal processor of a controller for a predetermined period of time after a radiation pulse has been emitted by the linac.
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公开(公告)号：US11794036B2
公开(公告)日：2023-10-24
申请号：US16890194
申请日：2020-06-02
Applicant: RefleXion Medical, Inc.
Inventor： Rostem Bassalow , Manat Maolinbay , Brent Harper
IPC: A61N5/10
CPC classification number: A61N5/107 , A61N5/1049 , A61N5/1075 , A61N2005/1051 , A61N2005/1057 , A61N2005/1061 , A61N2005/1076
Abstract: Described here are systems, devices, and methods for imaging and radiotherapy procedures. Generally, a radiotherapy system may include a radiotransparent patient platform, a radiation source coupled to a multi-leaf collimator, and a detector facing the collimator. The radiation source may be configured to emit a first beam through the collimator to provide treatment to a patient on the patient platform. A controller may be configured to control the radiotherapy system.
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