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1.发明授权公开(公告)号：US12115386B2
公开(公告)日：2024-10-15
申请号：US17571273
申请日：2022-01-07
Applicant: RefleXion Medical, Inc.
Inventor： Yevgen Voronenko , Debashish Pal , David Quentin Larkin , George Zdasiuk , Jayakrishnan Janardhanan , Michael Kirk Owens , Peter Demetri Olcott
IPC: A61N5/10
CPC classification number: A61N5/1031 , A61N5/1039 , A61N5/1043 , A61N5/1045 , A61N5/1084
Abstract: Disclosed herein are methods for patient setup and patient target region localization for the irradiation of multiple patient target regions in a single treatment session. Virtual localization is a method that can be used to register a patient target region without requiring that the patient is physically moved using the patient platform. Instead, the planned fluence is updated to reflect the current location of the patient target region by selecting a localization reference in the localization image, calculating a localization function based on the localization reference point, and calculating the delivery fluence by convolving the localization function with a shift-invariant firing filter. Mosaic multi-target localization partitions a planned fluence map for multiple patient target regions into sub-regions that can be individually localized. De-coupled multi-target localization involves generating a separate planned fluence map for each target but constraining a cumulative fluence map to ensure dosimetric goals are met.
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公开(公告)号：US11813481B2
公开(公告)日：2023-11-14
申请号：US17877719
申请日：2022-07-29
Applicant: RefleXion Medical, Inc.
Inventor： Debashish Pal , Ayan Mitra , Christopher Eric Brown , Peter Demetri Olcott , Yevgen Voronenko , Rostem Bassalow
IPC: A61N5/10
CPC classification number: A61N5/1031 , A61N5/1001 , A61N5/107 , A61N5/1045 , A61N5/1049 , A61N5/1065 , A61N5/1067 , A61N5/1069 , A61N5/1081 , A61N5/1036 , A61N5/1039 , A61N5/1075 , A61N2005/1019 , A61N2005/1041
Abstract: Systems and methods for shuttle mode radiation delivery are described herein. One method for radiation delivery comprises moving the patient platform through the patient treatment region multiple times during a treatment session. This may be referred to as patient platform or couch shuttling (i.e., couch shuttle mode). Another method for radiation delivery comprises moving the therapeutic radiation source jaw across a range of positions during a treatment session. The jaw may move across the same range of positions multiple times during a treatment session. This may be referred to as jaw shuttling (i.e., jaw shuttle mode). Some methods combine couch shuttle mode and jaw shuttle mode. Methods of dynamic or pipelined normalization are also described.
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公开(公告)号：US12214219B2
公开(公告)日：2025-02-04
申请号：US18295448
申请日：2023-04-04
Applicant: RefleXion Medical, Inc.
Inventor： Michael Kirk Owens , Rostem Bassalow , Peter Demetri Olcott , Yevgen Voronenko , David Quentin Larkin , Samuel Mazin
Abstract: Disclosed herein are systems and methods for adapting and/or updating radiotherapy treatment plans based on biological and/or physiological data and/or anatomical data extracted or calculated from imaging data acquired in real-time (e.g., during a treatment session). Functional imaging data acquired at the time of radiation treatment is used to modify a treatment plan and/or dose delivery instructions to provide a prescribed dose distribution to patient target regions. Also disclosed herein are methods for evaluating treatment plans based on imaging data acquired in real-time.
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公开(公告)号：US11633626B2
公开(公告)日：2023-04-25
申请号：US17235812
申请日：2021-04-20
Applicant: RefleXion Medical, Inc.
Inventor： Yevgen Voronenko , Peter Demetri Olcott , Debashish Pal , Rostem Bassalow
IPC: A61N5/10
Abstract: Disclosed herein are systems and methods for guiding the delivery of therapeutic radiation using incomplete or partial images acquired during a treatment session. A partial image does not have enough information to determine the location of a target region due to, for example, poor or low contrast and/or low SNR. The radiation fluence calculation methods described herein do not require knowledge or calculation of the target location, and yet may help to provide real-time image guided radiation therapy using arbitrarily low SNR images.
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公开(公告)号：US11287540B2
公开(公告)日：2022-03-29
申请号：US16887896
申请日：2020-05-29
Applicant: RefleXion Medical, Inc.
Inventor： Peter Demetri Olcott , Matthew Francis Bieniosek , Brent Harper
Abstract: Disclosed herein are methods and devices for the acquisition of positron emission (or PET) data in the presence of ionizing radiation that causes afterglow of PET detectors. In one variation, the method comprises adjusting a coincidence trigger threshold of the PET detectors during a therapy session. In one variation, the method comprises adjusting a gain factor used in positron emission data acquisition (e.g., a gain factor used to multiply and/or shift the output(s) of a PET detector(s)) during a therapy session. In some variations, a method for acquiring positron emission data during a radiation therapy session comprises suspending communication between the PET detectors and a signal processor of a controller for a predetermined period of time after a radiation pulse has been emitted by the linac.
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Patent Agency Ranking
公开(公告)号：US11033757B2
公开(公告)日：2021-06-15
申请号：US16554258
申请日：2019-08-28
Applicant: Reflexion Medical, Inc.
Inventor： Yevgen Voronenko , Peter Demetri Olcott , Debashish Pal , Rostem Bassalow
IPC: A61N5/10
Abstract: Disclosed herein are systems and methods for guiding the delivery of therapeutic radiation using incomplete or partial images acquired during a treatment session. A partial image does not have enough information to determine the location of a target region due to, for example, poor or low contrast and/or low SNR. The radiation fluence calculation methods described herein do not require knowledge or calculation of the target location, and yet may help to provide real-time image guided radiation therapy using arbitrarily low SNR images.
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公开(公告)号：US10688320B2
公开(公告)日：2020-06-23
申请号：US15993325
申请日：2018-05-30
Applicant: RefleXion Medical, Inc.
Inventor： Yevgen Voronenko , Peter Demetri Olcott , Debashish Pal , Rostem Bassalow
IPC: A61N5/10
Abstract: Disclosed herein are systems and methods for guiding the delivery of therapeutic radiation using incomplete or partial images acquired during a treatment session. A partial image does not have enough information to determine the location of a target region due to, for example, poor or low contrast and/or low SNR. The radiation fluence calculation methods described herein do not require knowledge or calculation of the target location, and yet may help to provide real-time image guided radiation therapy using arbitrarily low SNR images.
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公开(公告)号：US12233286B2
公开(公告)日：2025-02-25
申请号：US18472034
申请日：2023-09-21
Applicant: RefleXion Medical, Inc.
Inventor： Yevgen Voronenko , Jayakrishnan Janardhanan , Debashish Pal , Rostem Bassalow , Peter Demetri Olcott , Michael Kirk Owens
Abstract: Described herein are methods for beam station delivery of radiation treatment, where the patient platform is moved to a series of discrete patient platform locations or beam stations that are determined during treatment planning, stopped at each of these locations while the radiation source rotates about the patient delivering radiation to the target regions that intersect the radiation beam path, and then moving to the next location after the prescribed dose of radiation (e.g., in accordance with a calculated fluence map) for that location has been delivered to the patient.
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公开(公告)号：US11801398B2
公开(公告)日：2023-10-31
申请号：US17831105
申请日：2022-06-02
Applicant: RefleXion Medical, Inc.
Inventor： Yevgen Voronenko , Jayakrishnan Janardhanan , Debashish Pal , Rostem Bassalow , Peter Demetri Olcott , Michael Kirk Owens
CPC classification number: A61N5/1079 , A61B6/035 , A61B6/037 , A61B6/0407 , A61B6/4435 , A61B6/54 , A61N5/103 , A61N5/107 , A61N5/1045 , A61N5/1049 , A61N5/1071 , A61N5/1075 , A61N5/1081 , A61N5/1068 , A61N2005/1052 , A61N2005/1055 , A61N2005/1058 , A61N2005/1061 , A61N2005/1072
Abstract: Described herein are methods for beam station delivery of radiation treatment, where the patient platform is moved to a series of discrete patient platform locations or beam stations that are determined during treatment planning, stopped at each of these locations while the radiation source rotates about the patient delivering radiation to the target regions that intersect the radiation beam path, and then moving to the next location after the prescribed dose of radiation (e.g., in accordance with a calculated fluence map) for that location has been delivered to the patient.
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公开(公告)号：US11675097B2
公开(公告)日：2023-06-13
申请号：US17697828
申请日：2022-03-17
Applicant: Reflexion Medical, Inc.
Inventor： Peter Demetri Olcott , Matthew Francis Bieniosek , Brent Harper
CPC classification number: G01T1/2985 , G01T1/172 , G01T1/208 , G01T1/2023 , G01T7/005
Abstract: Disclosed herein are methods and devices for the acquisition of positron emission (or PET) data in the presence of ionizing radiation that causes afterglow of PET detectors. In one variation, the method comprises adjusting a coincidence trigger threshold of the PET detectors during a therapy session. In one variation, the method comprises adjusting a gain factor used in positron emission data acquisition (e.g., a gain factor used to multiply and/or shift the output(s) of a PET detector(s)) during a therapy session. In some variations, a method for acquiring positron emission data during a radiation therapy session comprises suspending communication between the PET detectors and a signal processor of a controller for a predetermined period of time after a radiation pulse has been emitted by the linac.
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