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公开(公告)号：US20220390471A1
公开(公告)日：2022-12-08
申请号：US17831232
申请日：2022-06-02
发明人： Ehud GAZIT , Dana LAOR , Dorin SADE YAZDI
IPC分类号： G01N33/68
摘要： The present disclosure provides yeast screening system/s and methods for screening of candidate therapeutic compound/s for treating, at least one proteniopathy and/or protein misfolding disorder. More specifically, the present disclosure provides systems and methods for identifying a therapeutic compound that inhibit Hcy fibril formation and uses thereof in treating Alzheimer's disease.
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公开(公告)号：US20210395312A1
公开(公告)日：2021-12-23
申请号：US17467297
申请日：2021-09-06
发明人： Ehud GAZIT , Kai TAO , Yu CHEN , Sharon GILEAD , Sigal LAZAR , Pandeeswar MAKAM
IPC分类号： C07K7/64
摘要： Self-assembled structures formed of a plurality of cyclic peptides which are in association with metal ions is provided. The cyclic peptides are each of from 2 to 6 amino acid residues, and two or more of the amino acid residues are each independently an aromatic amino acid residue. The self-assembled structures exhibit photoluminescence and can be used or incorporated in light emitting systems.
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公开(公告)号：US20200325203A1
公开(公告)日：2020-10-15
申请号：US16914388
申请日：2020-06-28
申请人： TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD. , RAMOT AT TEL AVIV UNIVERSITY LTD.
发明人： Genady KOSTENICH , Mor ORON-HERMAN , Arie ORENSTEIN , Talia SHEKHTER ZAHAVI , Ehud GAZIT , Yoseph SALITRA , Ludmila BUZHANSKY
摘要： Disclosed are Somatostatin receptor ligands comprising a peptide moiety, pharmaceutical compositions and uses thereof. Disclosed are also synthetic Somatostatin receptor ligands comprising a cyclic peptide moiety and an active agent moiety covalently bonded to the cyclic peptide moiety through a nitrogen atom of a side chain functional group of an internal residue of the cyclic peptide moiety, pharmaceutical compositions and uses thereof. Disclosed are also synthetic Somatostatin receptor ligands comprising a cyclic peptide moiety and a nanoparticle active agent moiety covalently bonded to the cyclic peptide moiety, pharmaceutical compositions and uses thereof.
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公开(公告)号：US20170298113A1
公开(公告)日：2017-10-19
申请号：US15509842
申请日：2015-09-10
申请人： TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD. , RAMOT AT TEL AVIV UNIVERSITY LTD.
发明人： Genady KOSTENICH , Mor ORON-HERMAN , Arie ORENSTEIN , Talia SHEKHTER ZAHAVI , Ehud GAZIT , Yoseph SALITRA , Ludmila BUZHANSKY
IPC分类号： C07K14/655 , A61K38/12 , A61K38/08
CPC分类号： C07K14/655 , A61K38/08 , A61K38/12 , A61K47/62 , A61K47/6923 , A61K47/6933 , A61K47/6937
摘要： Disclosed are Somatostatin receptor ligands comprising a peptide moiety, pharmaceutical compositions and uses thereof. Disclosed are also synthetic Somatostatin receptor ligands comprising a cyclic peptide moiety and an active agent moiety covalently bonded to the cyclic peptide moiety through a nitrogen atom of a side chain functional group of an internal residue of the cyclic peptide moiety, pharmaceutical compositions and uses thereof. Disclosed are also synthetic Somatostatin receptor ligands comprising a cyclic peptide moiety and a nanoparticle active agent moiety covalently bonded to the cyclic peptide moiety, pharmaceutical compositions and uses thereof.
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公开(公告)号：US20140044949A1
公开(公告)日：2014-02-13
申请号：US14061771
申请日：2013-10-24
发明人： Ehud GAZIT , Meital Reches
IPC分类号： D01F4/00
CPC分类号： D01F4/00 , C07K5/06078 , C07K5/06191 , C08J5/18 , C08J2300/16 , D01D5/00 , D01F1/10 , D01F6/68 , Y10T428/253 , Y10T428/298 , Y10T442/60 , Y10T442/614
摘要： A method of forming a fiber made of peptide nanostructures is disclosed. The method comprises: providing peptide nanostructures in solution, and fiberizing the solution thereby forming at least one fiber of the peptide nanostructures. Also disclosed are methods of forming films and other articles using the peptide nanostructures.
摘要翻译： 公开了一种形成由肽纳米结构制成的纤维的方法。 该方法包括：在溶液中提供肽纳米结构，并使溶液纤维化，从而形成肽纳米结构的至少一种纤维。 还公开了使用肽纳米结构形成膜和其它制品的方法。
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公开(公告)号：US20210170048A1
公开(公告)日：2021-06-10
申请号：US16071168
申请日：2017-01-19
申请人： RAMOT AT TEL-AVIV UNIVERSITY LTD. , TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD.
摘要： The present invention provides nanoparticle conjugates incorporating the self-assembling module diphenylalanine (FF) dipeptide into a bioactive moiety. The conjugate self-assembles to form distinct nanometric structures such as nanospheres. The present invention further provides nanoparticles formed by supramolecular co-assembly of the conjugates with a diphenylalanine (FF) dipeptide or analog thereof, to generate bioactive self-assembled nanostructures.
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公开(公告)号：US20160108434A1
公开(公告)日：2016-04-21
申请号：US14880311
申请日：2015-10-12
发明人： Iftach YACOBY , Ehud GAZIT , Nathan NELSON , Itai BENHAR
CPC分类号： C12P3/00 , C12M21/02 , C12M21/18 , C12M31/10 , C12M47/10 , C12N9/0067 , C12N9/96 , C12N15/62 , C12Y112/98002
摘要： An isolated polypeptide comprising a hydrogen generating enzyme attached to a heterologous ferredoxin is disclosed, as well as polynucleotides encoding same, nucleic acid constructs capable of expressing same and cells expressing same. A method for generating hydrogen using the isolated polypeptide is also disclosed.
摘要翻译： 公开了包含与异源铁氧还蛋白连接的产氢酶的分离的多肽，以及编码其的多核苷酸，能够表达其的核酸构建体和表达相同的细胞。 还公开了使用分离的多肽产生氢的方法。
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8.发明申请NAPHTHOQUINONE DERIVATIVES USEFUL FOR PREVENTION OF AMYLOID DEPOSITS AND TREATMENT OF DISEASES INVOLVING AMYLOIDOGENESIS 有权用于预防淀粉样沉积物和治疗涉及淀粉样变性疾病的萘普隆酮衍生物公开(公告)号：US20140213627A1
公开(公告)日：2014-07-31
申请号：US14168550
申请日：2014-01-30
发明人： Roni SCHERZER , Ehud GAZIT , Daniel SEGAL
IPC分类号： C07C309/14 , C07C211/54 , C07D245/04 , C07C229/18 , C07D207/09 , C07C229/60 , C07D209/14 , C07D209/20
CPC分类号： C07C309/14 , A61K31/198 , A61K31/255 , A61K31/395 , A61K31/405 , C07C211/54 , C07C229/18 , C07C229/60 , C07D207/09 , C07D209/14 , C07D209/20 , C07D245/04
摘要： The present invention provides pharmaceutical compositions comprising substituted 1,4 naphthoquinones that are effective in preventing oligomerization of beta amyloid and subsequent pathologies associated with amyloid fibrils. These compositions are useful for the treatment of disease involving amyloidogenesis including neurodegenerative diseases such as Alzheimer's Disease or senile dementia. Particularly effective compositions comprise 1,4 naphthoquinones substituted with an amino acid residue selected from a heterocyclic or aromatic amino acid.
摘要翻译： 本发明提供了包含取代的1,4-萘醌的药物组合物，其有效预防β淀粉样蛋白的低聚和随后与淀粉样蛋白原纤维相关的病理学。 这些组合物可用于治疗包括淀粉样变性（包括神经变性疾病如阿尔茨海默病或老年痴呆）的疾病。 特别有效的组合物包含被选自杂环或芳族氨基酸的氨基酸残基取代的1,4萘醌。
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公开(公告)号：US20220190232A1
公开(公告)日：2022-06-16
申请号：US17442765
申请日：2020-03-25
发明人： Ehud GAZIT , Santu BERA , Yu CHEN , Sharon GILEAD , Kai TAO , Sigal LAZAR , Rusen YANG , Sudipta MONDAL , Vasantha BASAVALINGAPPA
IPC分类号： H01L41/193 , C07K5/097 , C07K5/083 , C07K5/087 , C07K5/065
摘要： A piezoelectric transducer is provided herein, comprising a three-dimensional structure made of a plurality of peptides, the peptides being self-assembling and the structure being piezoelectric, wherein at least a portion, or each, of said plurality of peptides comprises peptides of 2 to 10 amino acid residues, provided that the plurality of peptides is not consisted of a plurality of Phe-Phe dipeptides. Further described herein are peptides having an amino acid sequence Hyp-Phe-Phe, Boc-Dip-Dip, (L)Trp-(D)Trp or (D)Trp-(L)Trp, as well as three-dimensional structures comprising such peptides.
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公开(公告)号：US20210381022A1
公开(公告)日：2021-12-09
申请号：US17345248
申请日：2021-06-11
发明人： Ehud GAZIT , Dana LAOR
IPC分类号： C12Q1/02 , G01N33/569 , G01N33/50 , A61K49/00 , A61K31/122 , A61K31/353
摘要： The invention relates to in vivo systems and high throughput screening platform for drugs applicable in inborn error of metabolism (IEM) disorders. More specifically, the invention provides yeast screening system of candidate therapeutic compounds applicable in IEM disorders associated with accumulation of at least one metabolite. The systems of the invention comprise yeast cell/s that carry at least one manipulation in at least one yeast metabolic pathway, that leads to accumulation of said metabolite.
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