公开(公告)号：US20130267433A1

公开(公告)日：2013-10-10

申请号：US13740367

申请日：2013-01-14

Applicant: POSTECH ACADEMY-INDUSTRY FOUNDATION

Inventor： Hyung Joon CHA ,  Chang Sup KIM ,  Jeong Hyun SEO ,  Hwahui SHIN

IPC: G01N33/569

CPC classification number: G01N33/56911 ,  G01N2333/28

Abstract: The present invention related to a saccharide-based cholera toxin detection sensor for detection of Vibrio cholerae and its use. More specifically, the present invention relates to a carbohydrate chip for detection of Vibrio cholerae, a method for detecting Vibrio cholerae using the same, and a method for preparing the same, where the carbohydrate chip comprises GM1 pentasaccharide, GM2 tetrasaccharide, asialo GM1 tetrasaccharide, GM3 trisaccharide, galactose-β 1,3-N-acetylgalactosamine, lactose, and sialic acid that are immobilized on the surface of a solid substrate.

Abstract translation: 本发明涉及用于检测霍乱弧菌的糖类霍乱毒素检测传感器及其用途。 更具体地说，本发明涉及用于检测霍乱弧菌的碳水化合物芯片，使用其的霍乱弧菌检测方法及其制备方法，其中碳水化合物芯片包含GM1五糖，GM2四糖，脱ial GM1四糖， GM3三糖，半乳糖-β1,3-N-乙酰半乳糖胺，乳糖和唾液酸，其固定在固体基质的表面上。

公开(公告)号：US20170049669A1

公开(公告)日：2017-02-23

申请号：US15307800

申请日：2015-04-29

Applicant: POSTECH ACADEMY-INDUSTRY FOUNDATION

Inventor： Dong Soo HWANG ,  Dong Yeop OH ,  Jin-Soo AHN ,  Hyung Joon CHA ,  Sang-Ho JUN ,  Sung-Won JU ,  Ekavianty PRAJATELISTIA

IPC: A61K8/19 ,  A61K8/29 ,  A61K8/60 ,  A61K8/25 ,  A61Q11/00 ,  A61K8/24

CPC classification number: A61K8/19 ,  A61K8/0241 ,  A61K8/24 ,  A61K8/25 ,  A61K8/29 ,  A61K8/368 ,  A61K8/602 ,  A61K2800/412 ,  A61K2800/413 ,  A61K2800/92 ,  A61Q11/00

Abstract: The present invention relates to a composition for oral application and a method for preparing the same, more particularly, to a composition for oral application comprising a complex of specific Lewis base and specific Lewis acid, and a method for preparing the same. The composition for oral application of the present invention has excellent durability, body stability and coatibility, and thus, can effectively treat dentin hypersensitivity, and when applied before dentin hypersensitivity occurs, can prevent dentin hypersensitivity.

Abstract translation: 本发明涉及用于口服的组合物及其制备方法，更具体地涉及一种口服应用组合物，其包含特异性路易斯碱和特定路易斯酸的络合物及其制备方法。 本发明的口服应用组合物具有优异的耐久性，身体稳定性和涂布性，因此能够有效地治疗牙本质过敏，并且在牙质过敏发生时应用时，能够防止牙质过敏。

公开(公告)号：US20160222371A1

公开(公告)日：2016-08-04

申请号：US15131146

申请日：2016-04-18

Applicant: POSTECH ACADEMY-INDUSTRY FOUNDATION

Inventor： Hyung Joon CHA ,  Byung Hoon Jo ,  Jeong Hyun Seo

IPC: C12N9/88 ,  B01D53/84 ,  B01D53/62

CPC classification number: C12N9/88 ,  B01D53/1475 ,  B01D53/62 ,  B01D53/84 ,  B01D2251/304 ,  B01D2251/306 ,  B01D2251/606 ,  B01D2252/20484 ,  B01D2252/20489 ,  B01D2252/20494 ,  B01D2252/602 ,  B01D2255/804 ,  B01D2257/504 ,  C12Y402/01001 ,  Y02C10/04 ,  Y02C10/06 ,  Y02P20/59

Abstract: The present invention relates to a carbonic anhydrase, a nucleic acid molecule encoding the carbonic anhydrase, a recombinant vector including the nucleic acid molecule, a host cell transformed with the recombinant vector, and a method of preparing the carbonic anhydrase using the host cell. The carbonic anhydrase of the present invention has an excellent stability at high temperature to exhibit a carbon dioxide capturing activity even at high temperature, thereby being applied to a carbon dioxide capturing process performed at high temperature with many advantages in view of economic aspect due to mass-production of expression system.

Abstract translation: 本发明涉及碳酸酐酶，编码碳酸酐酶的核酸分子，包含核酸分子的重组载体，用重组载体转化的宿主细胞，以及使用宿主细胞制备碳酸酐酶的方法。 本发明的碳酸酐酶在高温下具有优异的稳定性，即使在高温下也显示出二氧化碳捕获活性，因此适用于在高温下进行的二氧化碳捕集过程，鉴于质量的经济方面具有许多优点 生产表达系统。

公开(公告)号：US20140005356A1

公开(公告)日：2014-01-02

申请号：US13917766

申请日：2013-06-14

Applicant: POSTECH ACADEMY-INDUSTRY FOUNDATION

Inventor： Hyung Joon CHA ,  Byeongseon Yang ,  Yoo Seong Choi ,  Hyungdon Yun

IPC: C07K14/435

CPC classification number: A61K38/16 ,  C07K14/43504

Abstract: The present invention relates to recombinant mussel adhesive protein wherein a DOPA residue is in vivo incorporated instead of a tyrosine residue, and a method for producing the same. More specifically, the present invention relates to recombinant mussel adhesive protein wherein a DOPA residue is incorporated instead of a tyrosine residue, and a method for producing the same, and a transformant for producing the recombinant mussel adhesive protein.

Abstract translation: 本发明涉及重组贻贝粘合蛋白，其中DOPA残基被体内掺入而不是酪氨酸残基及其制备方法。 更具体地，本发明涉及其中掺入DOPA残基而不是酪氨酸残基的重组贻贝粘合蛋白及其制备方法，以及用于生产重组贻贝粘合蛋白的转化体。

公开(公告)号：US20190307688A1

公开(公告)日：2019-10-10

申请号：US16330068

申请日：2017-09-01

Applicant: POSTECH ACADEMY-INDUSTRY FOUNDATION

Inventor： Hyung Joon CHA ,  Tae Yoon PARK ,  Hyo Jeong KIM ,  Bong Hyuk CHOI

IPC: A61K9/127 ,  A61K9/51 ,  A61K47/69 ,  C12N5/074

Abstract: The present disclosure relates to a novel stem cell carrier and a method for producing the same and provides a method for producing a stem cell carrier including a step of contacting stem cells with a coacervate formed by mixing an anionic polymer with a mussel adhesive protein or a mutant thereof. The present disclosure relates to a novel stem cell therapeutic agent platform of delivering cells in a encapsulated state by forming an adhesive cell carrier using crosslinked coacervate. The cell carrier of the present disclosure can maintain the ability to differentiate stem cells as well as biocompatibility and can survive without losing cell adhesion even under oxygen-deficient conditions. In addition, the cell carrier of the present disclosure has an excellent regenerative effect by applying such to biological tissues in which vascular regeneration is not easy, by inducing a metabolic reaction triggered by the hypoxic environment, in particular, neovascularization.

公开(公告)号：US20170190746A1

公开(公告)日：2017-07-06

申请号：US15394663

申请日：2016-12-29

Applicant: POSTECH ACADEMY-INDUSTRY FOUNDATION

Inventor： Hyung Joon CHA ,  Bong Hyuk CHOI ,  Eun Young JEON

IPC: C07K14/435 ,  A61L24/00 ,  A61L24/10 ,  C07K7/08 ,  A61K8/64

CPC classification number: C07K14/43504 ,  A61K8/64 ,  A61K8/987 ,  A61K38/00 ,  A61L24/0015 ,  A61L24/0031 ,  A61L24/043 ,  A61L24/108 ,  A61L26/0047 ,  A61L26/0052 ,  A61L26/0061 ,  A61L26/008 ,  A61L2300/412 ,  A61L2400/06 ,  A61Q19/00 ,  C07K7/08 ,  C07K2319/70 ,  C08L5/02 ,  C08L5/04 ,  C08L5/12 ,  C08L5/08 ,  C08L89/00

Abstract: Provided are a recombinant polypeptide in which a small leucine-rich proteoglycan mimetic sequence is attached to a terminal of a mussel adhesive protein, a composition for wound healing including the same, a bioadhesive material, and a preparation method thereof. According to the present disclosure, the recombinant polypeptide in which the small leucine-rich proteoglycan mimetic sequence is attached to the terminal of the mussel adhesive protein has an excellent epidermal regeneration effect in which the wound site is uniformly restored by promoting rapid wound healing at the wound site when being applied to the wound site and inducing formation of collagens which are arranged and concentrated at the wound site, and thus can be usefully used as various drugs, cosmetics, and quasi-drugs.

公开(公告)号：US20160096868A1

公开(公告)日：2016-04-07

申请号：US14749844

申请日：2015-06-25

Applicant: POSTECH ACADEMY-INDUSTRY FOUNDATION

Inventor： Hyung Joon CHA ,  Yun Kee Jo ,  Hogyun Cheong ,  Changsup Kim ,  Bong-Hyuk Choi

IPC: C07K14/435

CPC classification number: A61L27/025 ,  A61K38/00 ,  A61L27/30 ,  A61L27/3604 ,  C07K14/43509 ,  C07K2319/00

Abstract: The present invention relates to a fusion protein comprising a mussel adhesive protein and a silica-binding peptide linked to the mussel adhesive protein, a silica nanoparticle a silica connected to the fusion protein, a fusion protein-silica nanoparticle complex comprising the silica nanoparticle having bioactivity and adhesiveness for cell proliferation and accelerating the differentiation, a surface coating composition including the complex, its use, and a method of coating a surface using the surface coating composition.

Abstract translation: 本发明涉及包含贻贝粘合蛋白和与贻贝粘合蛋白连接的二氧化硅结合肽的融合蛋白，二氧化硅纳米颗粒与融合蛋白连接的二氧化硅，包含具有生物活性的二氧化硅纳米颗粒的融合蛋白 - 二氧化硅纳米颗粒复合物 以及细胞增殖的粘附性和促进分化，包括复合物的表面涂料组合物，其用途和使用表面涂料组合物涂布表面的方法。

公开(公告)号：US20160017279A1

公开(公告)日：2016-01-21

申请号：US14874508

申请日：2015-10-05

Applicant: Postech Academy-Industry Foundation

Inventor： Hyung Joon CHA ,  Bum Jin Kim ,  Yoo Seong Choi ,  Bong-Hyuk Choi

IPC: C12N5/00

CPC classification number: C12N5/0068 ,  B82Y5/00 ,  C07K14/43504 ,  C12N5/0654 ,  C12N2533/10 ,  C12N2533/40 ,  C12N2533/50 ,  C12N2533/70 ,  C12N2533/80 ,  C12N2537/00

Abstract: The present invention relates to technology of immobilizing or coating various functional bioactive substances on various surfaces without physical chemical treatment using mussel adhesive protein. More specifically, the present invention relates to a functional scaffold for tissue engineering comprising artificial extracellular matrix, manufactured by coating various functional bioactive substances on the surface of nanofiber and metal scaffold using mussel adhesive protein, and a method of manufacturing the same.