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1.发明申请公开(公告)号：US20180218434A1
公开(公告)日：2018-08-02
申请号：US15846646
申请日：2017-12-19
Applicant: Orig3n, Inc.
Inventor： Robin Y. Smith , Marcie A. Glicksman , Sunil Anant Gupta , Edward Joseph Coffey , Kate Blanchard , Stephanie Lento , Shadrack Cgar Frazier
CPC classification number: G06Q30/0631 , G06Q30/02 , G06Q30/0241 , G06Q30/0251 , G06Q30/0269 , G06Q30/06 , G06Q30/0643 , G16H20/60
Abstract: Presented herein are systems and methods for automatically identifying and recommending purchases (e.g., in-app purchases) to a user based on the user's personal genetic profile. In certain embodiments, offers for such purchases are conveniently presented in the same software application (e.g., smartphone app or other computing device application) in which a user securely accesses his or her personalized genetic profile test results. Also presented herein are systems and methods for computer application developers to customize apps for presentation of recommended purchases based on a user's personal genetic profile. In certain embodiments, the systems and methods described herein provide for issuing of genetically tailored notifications to one or more mobile health devices of an individual based on an assessment of the individual's genetic profile. Such notifications, for example, can assist an individual in their adherence to particular recommended regiments, such as workout regimens.
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公开(公告)号：US20160171159A1
公开(公告)日：2016-06-16
申请号：US14970822
申请日：2015-12-16
Applicant: ORIG3N Inc.
Inventor： Robin Y. Smith
CPC classification number: G06F19/321 , G06K9/00442 , G06K9/00671
Abstract: Disclosed are methods for analyzing blood and displaying information related to blood type. A method may be a computer-implemented method or utilize computer-implemented steps. Some aspects of the invention relate to a system for analyzing blood, comprising a computer, wherein the computer is configured to identify a blood type. The computer may be, for example, a tablet computer or smartphone.
Abstract translation: 公开了分析血液和显示与血型相关的信息的方法。 方法可以是计算机实现的方法或者利用计算机实现的步骤。 本发明的一些方面涉及一种用于分析血液的系统，包括计算机，其中所述计算机被配置为识别血液类型。 计算机可以是例如平板电脑或智能电话。
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公开(公告)号：US20210187040A1
公开(公告)日：2021-06-24
申请号：US16643812
申请日：2018-03-14
Applicant: Orig3n, Inc.
Inventor： Robin Y. Smith , Marcie A. Glicksman
IPC: A61K35/545 , C12N5/077 , C12N5/074 , C07K14/52 , C12N15/113 , C12N9/22 , C12N5/078 , C12N5/0775
Abstract: Presented herein are methods of producing “personalized” secretome compositions suitable for secretome based therapy to be administered to a specific individual and/or specific group of individuals. The iPSCs and/or iPSC-derived cells, and any iPSC-derived compositions derived therefrom, are identified as compatible with a specific individual or specific group of individuals using an identification of a cell type indicative of compatibility such as an HLA match and/or ABO blood match and/or RHD blood group match. The identified compatible cells are then retrieved from a managed HLA-indexed (and/or otherwise indexed) repository or are derived from a biological sample of a suitable donor. The retrieved compatible cells are then used to derive the “personalized” iPSC-derived secretome compositions, that comprise the complete secretome or a subset of the secretome suitable for treatment of a specific individual and/or specific group of individuals.
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公开(公告)号：US20180245051A1
公开(公告)日：2018-08-30
申请号：US15965313
申请日：2018-04-27
Applicant: Orig3n, Inc.
Inventor： Robin Y. Smith , Marcie A. Glicksman , Nikhat F. Zaidi
CPC classification number: C12N5/0696 , B01L3/502761 , B01L2200/0652 , C12N2500/32 , C12N2500/34 , C12N2500/90 , C12N2501/065 , C12N2501/15 , C12N2501/36 , C12N2506/45 , G01N15/042 , G01N15/14 , G01N15/1459 , G01N33/52 , G01N2015/1006 , G01N2015/149
Abstract: The techniques described herein provide for improved efficiency of iPSC production from biological cells. The approach achieves improved iPSC production efficiency by obtaining a set of cells whose cell cycles are synchronized at a specific, desired cell cycle phase, such as mitotic phase (also referred to as M phase). The efficacy with which such synchronized cells can be transformed into iPSCs is higher than for an arbitrary set of cells that comprises cells at a variety of different stages in their cycles. Accordingly, the approaches described herein allow efficient generation of iPSCs, thereby facilitating myriad technologies for personalized and regenerative medicine that rely upon the effective production of iPSCs.
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公开(公告)号：US20180132773A1
公开(公告)日：2018-05-17
申请号：US15808347
申请日：2017-11-09
Applicant: Orig3n, Inc.
Inventor： Robin Y. Smith , Kate Blanchard
CPC classification number: A61B5/150305 , A61B5/15003 , A61B5/150328 , A61B5/150343 , A61B5/150389 , A61B5/150503 , A61B5/150732 , A61B5/15074 , A61B5/150786 , A61B5/153 , A61B17/132 , A61B17/1322 , A61B50/3001 , A61B50/31 , A61B50/312 , A61B2050/005 , A61B2050/314 , A61F13/00072 , A61F13/36 , A61F17/00 , A61F2013/00089
Abstract: Described herein are various systems, methods, apparatuses, and kits for phlebotomy. In certain embodiments, the phlebotomy kit or system includes a blood collection tube, a needle assembly, a holder for the blood collection tube, a bandage, a tourniquet, a wipe, and an absorbent pad. The disclosed systems, methods, apparatuses, and kits are useful for collecting a single small volume of blood, and collecting of a small volume of blood at remote non-hospital environments.
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Patent Agency Ranking
公开(公告)号：US20200289098A1
公开(公告)日：2020-09-17
申请号：US16820451
申请日：2020-03-16
Applicant: Orig3n, Inc.
Inventor： Robin Y. Smith , Marcie A. Glicksman , Mike Robbat
Abstract: The disclosed technology relates generally to devices, kits, and related methods for collecting biological samples for genetic testing. In various embodiments, a DNA collection device for collecting cells from an orifice of a human subject includes an elongate arm. The DNA collection device further includes a swab head disposed at a distal end of the elongate arm, wherein the swab head is sized to at least partially enter the orifice, and wherein the swab head comprises a plurality of bristles disposed on a surface of the swab head.
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7.发明申请公开(公告)号：US20200206267A1
公开(公告)日：2020-07-02
申请号：US16643814
申请日：2018-03-14
Applicant: Orig3n, Inc.
Inventor： Robin Y. Smith , Marcie A. Glicksman
IPC: A61K35/17 , C07K14/725 , G06F17/18
Abstract: Presented herein are systems and methods of producing “universal” and/or “off-the-shelf” CAR-T compositions suitable for cancer therapy to be administered to one or more individuals. A CAR-T composition is a composition comprising one or more types of chimeric antigen receptor T cells (CAR-T). The iPSCs and/or cell lines, and any iPSC-derived CAR-T compositions derived therefrom, are identified as compatible with one or more individuals using an identification of a cell type indicative of compatibility (e.g., HLA match and/or ABO blood match and/or RHD blood match). The compatible cells are then retrieved from a managed HLA-indexed (and/or otherwise indexed) repository or are derived from a biological sample of a donor. The retrieved compatible cells are then used to derive iPSC-derived CAR-T compositions, wherein the derived compositions are suitable for therapy of one or more individuals.
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8.发明申请公开(公告)号：US20200013481A1
公开(公告)日：2020-01-09
申请号：US16482946
申请日：2018-02-01
Applicant: Orig3n, Inc.
Inventor： Robin Y. Smith , Marcie A. Glicksman
Abstract: Described herein are various systems and methods for customizing cell culture media for optimized cell proliferation based on genetic traits of the cells. Factors of the cells, such as genetics, can determine the optimum cell culture conditions for growth and use of individual cells in vitro. In certain embodiments, genetics can determine sensitivity from a toxic perspective. In certain embodiments, genetics can determine what concentration(s) of growth factor(s) and nutrient(s) are required for optimum growth.
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9.发明申请公开(公告)号：US20190355441A1
公开(公告)日：2019-11-21
申请号：US16482945
申请日：2018-02-01
Applicant: Orig3n, Inc.
Inventor： Robin Y. Smith , Sunil Anant Gupta
Abstract: A meter value that reflects the amount of genetic material stored in a reserve is stored in a database for each reserve in a bank. Meter values allow a user to track the amount of genetic material in the reserves of a bank without needing to physically measure or disturb the reserves unnecessarily. As users withdraw and deposit genetic material from and into a reserve, the meter value is changed to reflect the change in the amount of genetic material in the reserve. In certain embodiments, the use of meter values enables accurate and instant accounting of a large number of reserves of genetic material for a large number of individuals. Users and/or individuals may be notified when a meter value falls below a threshold. Notifications may prompt a user to generate additional genetic material from biological sample or an individual to provide additional biological sample.
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公开(公告)号：US20180173842A1
公开(公告)日：2018-06-21
申请号：US15445752
申请日：2017-02-28
Applicant: Orig3n, Inc.
Inventor： Robin Y. Smith , Kate Blanchard , Sunil Anant Gupta , Edward Joseph Coffey , Marcie A. Glicksman , Brian Phillips
Abstract: Presented herein are systems and methods related to a scalable and platform-agnostic framework that facilitates the creation of personal genetic profile products. In particular, in certain embodiments, the systems and methods described herein facilitate the creation, storage, organization, and maintenance (e.g. updating) of data corresponding to the relationships between particular variations that may occur in an individual's DNA (e.g. variants of different specific SNPs) and the health-related phenotypes that they influence. The data stored in this manner can be used as a template not only for presenting personal genetic profile assessments to an individual in an informative and user-friendly manner, but also for the rapid, automated creation of personal genetic profile assessments of a plurality of individuals from data corresponding to genotyping measurements of biological samples provided by the individuals.
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