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    Method and device to treat kidney disease
    1.
    发明授权
    Method and device to treat kidney disease 有权
    治疗肾脏疾病的方法和装置

    公开(公告)号：US08641659B2

    公开(公告)日：2014-02-04

    申请号：US13399910

    申请日：2012-02-17

    申请人： Orhan Soykan ,  Carl Schu ,  Kimberly Chaffin

    发明人： Orhan Soykan ,  Carl Schu ,  Kimberly Chaffin

    IPC分类号： A61M1/00

    CPC分类号： A61M1/28 ,  A61M1/1678 ,  A61M1/1696 ,  A61M1/284 ,  A61M2205/04

    摘要： The invention relates to a method and device for dialysis and or bulk fluid removal by generating a fibrosis chamber within a body cavity and performing dialysis or bulk fluid removal. An implantable medical device is described having a fibrosis chamber and a pump. A dialysis chamber and an optional electrodialysis unit can further be provided. An additional controller uses sensory feedback to regulate the fluid levels by altering the extracellular fluid retention within the fibrosis chamber. This device can be used for the treatment of patients with chronic kidney disease who may also be suffering from cardiorenal syndrome and hypertension.

    摘要翻译： 本发明涉及一种通过在体腔内产生纤维化腔并进行透析或大量流体去除来透析和/或大量流体去除的方法和装置。 描述了具有纤维化室和泵的可植入医疗装置。 可以进一步提供透析室和可选的电渗析装置。 附加的控制器使用感官反馈来通过改变纤维化腔内的细胞外液体保留来调节流体水平。 该装置可用于治疗也可能患有心脏肾综合征和高血压的慢性肾脏疾病患者。

    Process for producing a hyper-elastic, high strength dilatation balloon made from multi-block copolymers
    2.
    发明申请
    Process for producing a hyper-elastic, high strength dilatation balloon made from multi-block copolymers 审中-公开
    用于生产由多嵌段共聚物制成的超弹性高强度膨胀气球的方法

    公开(公告)号：US20050098914A1

    公开(公告)日：2005-05-12

    申请号：US10920458

    申请日：2004-08-18

    申请人： Ashish Varma ,  Kimberly Chaffin ,  Frank Bates ,  Marc Hillmyer ,  Lisa Lim ,  Tamotsu Harada

    发明人： Ashish Varma ,  Kimberly Chaffin ,  Frank Bates ,  Marc Hillmyer ,  Lisa Lim ,  Tamotsu Harada

    IPC分类号： A61L29/00 ,  A61L29/04 ,  A61M25/00 ,  B29C47/00 ,  B29C55/04 ,  B29C55/12 ,  B29C71/00 ,  B65D1/00

    CPC分类号： A61L29/04 ,  A61L29/049 ,  C08L53/00 ,  Y10T428/1352

    摘要： A self-wrapping dilatation balloon comprising a multiblock copolymer having high elasticity and elastic recovery from nominal strains greater than about 30% is described. Also described herein, is a polymeric extrudate for making a dilatation balloon comprising a multiblock copolymer having tensile strength in the range of about 50 MPa to about 450 MPa, strain at break in the range of about 50% to about 600% and substantially complete elastic recovery from nominal strains of at least about 30%. The extrudate has phase-separated microdomains that are macroscopically aligned in parallel, perpendicular, transverse or a combination thereof. Also described herein is a process for producing a polymeric extrudate for use as a dilatation balloon. The process comprises extruding a multiblock copolymer mixture or composition to form an extrudate. The extruding is done such that the extrudate has phase-separated microdomains that are macroscopically aligned in parallel, perpendicular, transverse or a combination thereof. After extrusion, the process optionally comprises the steps of drawing and coagulating the extrudate.

    摘要翻译： 描述了包含具有高于约30％的标称应变的高弹性和弹性恢复的多嵌段共聚物的自包裹膨胀气球。 本文还描述了一种用于制造膨胀气囊的聚合物挤出物，其包含具有约50MPa至约450MPa范围内的拉伸强度，约50％至约600％范围内的拉伸应变和基本上完全弹性的多嵌段共聚物 从名义菌株中恢复至少约30％。 挤出物具有相分离的微区域，它们在宏观上对齐，平行，垂直，横向或其组合。 本文还描述了用于生产用作膨胀气球的聚合物挤出物的方法。 该方法包括挤出多嵌段共聚物混合物或组合物以形成挤出物。 进行挤出使得挤出物具有相互分离的微区域，其宏观地对准在平行，垂直，横向或其组合。 挤出后，该方法任选地包括拉伸和凝结挤出物的步骤。

    Reinforcement of boney material surrounding a bone implant
    6.
    发明申请
    Reinforcement of boney material surrounding a bone implant 审中-公开
    加固骨植入物周围的骨料

    公开(公告)号：US20070260250A1

    公开(公告)日：2007-11-08

    申请号：US11429031

    申请日：2006-05-05

    申请人： Paul Wisnewski ,  Kimberly Chaffin ,  Naim Istephanous ,  Brett Vegoe

    发明人： Paul Wisnewski ,  Kimberly Chaffin ,  Naim Istephanous ,  Brett Vegoe

    IPC分类号： A61B17/86

    CPC分类号： A61B17/864 ,  A61B17/7098 ,  A61B2017/00004 ,  A61B2017/8655

    摘要： A screw structured to engage bone has a stem with threads and an inner chamber. The inner chamber is in fluid communication with one or more ports along the stem. A polymeric material is provided with the screw. After implantation of the screw in bone, energy is applied to the polymeric material to convert the material to a more fluid form, and while in this form, the polymeric material is flowed from the inner chamber and out through the one or more ports into boney material to provide reinforcement.

    摘要翻译： 构造成接合骨的螺钉具有带螺纹和内腔的杆。 内室与沿着杆的一个或多个端口流体连通。 聚合材料设置有螺钉。 在将螺钉植入骨骼之后，将能量施加到聚合物材料上以将材料转化为更流体的形式，而在这种形式下，聚合物材料从内室流出并通过一个或多个端口流出到 材料提供加固。

    DISSOLVABLE PHARMACEUTICAL IMPLANT
    7.
    发明申请
    DISSOLVABLE PHARMACEUTICAL IMPLANT 审中-公开
    不溶性药物植入物

    公开(公告)号：US20100317629A1

    公开(公告)日：2010-12-16

    申请号：US12814281

    申请日：2010-06-11

    申请人： Genevieve L. Gallagher ,  Kimberly Chaffin ,  Zhongping Yang

    发明人： Genevieve L. Gallagher ,  Kimberly Chaffin ,  Zhongping Yang

    IPC分类号： A61K31/65 ,  A61P31/00 ,  A61P7/04 ,  A61P29/00 ,  A61P25/04 ,  A61N1/00

    CPC分类号： A61K9/0024 ,  A61K9/2009 ,  A61K9/2018 ,  A61K9/2027 ,  A61K9/2054 ,  A61K9/2059 ,  A61K9/2095 ,  A61K45/06

    摘要： A pharmaceutical implant may include a pharmaceutical and at least one excipient, and may be configured to be implanted in a body of a patient. The at least one excipient may dissolve after implantation of the pharmaceutical implant in the body of the patient and release the pharmaceutical. In some examples, the pharmaceutical implant includes at least two pharmaceuticals. The at least one excipient may be selected to provide a desired release profile of the pharmaceutical. For example, the pharmaceutical implant may be configured to dissolve and release the pharmaceutical over a length of time between about one day and about 30 days. In some examples, the pharmaceutical implant may be implanted in the body of the patient proximate to an implantable medical device.

    摘要翻译： 药物植入物可以包括药物和至少一种赋形剂，并且可以被配置成植入患者体内。 所述至少一种赋形剂在将所述药物植入物植入患者体内后可以溶解并释放药物。 在一些实例中，药物植入物包括至少两种药物。 可以选择至少一种赋形剂以提供药物的期望释放曲线。 例如，药物植入物可以构造成在约一天至约30天之间的一段时间内溶解和释放药物。 在一些实例中，药物植入物可以植入患者体内，靠近植入式医疗装置。

    Hyper-elastic, high strength dilatation balloon made from multi-block copolymers
    8.
    发明申请
    Hyper-elastic, high strength dilatation balloon made from multi-block copolymers 审中-公开
    由多嵌段共聚物制成的超弹性高强度膨胀球囊

    公开(公告)号：US20050118370A1

    公开(公告)日：2005-06-02

    申请号：US10920457

    申请日：2004-08-18

    申请人： Ashish Varma ,  Kimberly Chaffin

    发明人： Ashish Varma ,  Kimberly Chaffin

    IPC分类号： A61L29/00 ,  A61L29/04 ,  A61M25/00 ,  B29C47/00 ,  B29C55/04 ,  B29C55/12 ,  B29C71/00 ,  B65D1/00

    CPC分类号： A61L29/04 ,  A61L29/049 ,  C08L53/00 ,  Y10T428/1352

    摘要： A self-wrapping dilatation balloon comprising a multiblock copolymer having high elasticity and elastic recovery from nominal strains greater than about 30% is described. Also described herein, is a polymeric extrudate for making a dilatation balloon comprising a multiblock copolymer having tensile strength in the range of about 50 MPa to about 450 MPa, strain at break in the range of about 50% to about 600% and substantially complete elastic recovery from nominal strains of at least about 30%. The extrudate has phase-separated microdomains that are macroscopically aligned in parallel, perpendicular, transverse or a combination thereof. Also described herein is a process for producing a polymeric extrudate for use as a dilatation balloon. The process comprises extruding a multiblock copolymer mixture or composition to form an extrudate. The extruding is done such that the extrudate has phase-separated microdomains that are macroscopically aligned in parallel, perpendicular, transverse or a combination thereof. After extrusion, the process optionally comprises the steps of drawing and coagulating the extrudate.

    摘要翻译： 描述了包含具有高于约30％的标称应变的高弹性和弹性恢复的多嵌段共聚物的自包裹膨胀气球。 本文还描述了一种用于制造膨胀气囊的聚合物挤出物，其包含具有约50MPa至约450MPa范围内的拉伸强度，约50％至约600％范围内的拉伸应变和基本上完全弹性的多嵌段共聚物 从名义菌株中恢复至少约30％。 挤出物具有相分离的微区域，它们在宏观上对齐，平行，垂直，横向或其组合。 本文还描述了用于生产用作膨胀气球的聚合物挤出物的方法。 该方法包括挤出多嵌段共聚物混合物或组合物以形成挤出物。 进行挤出使得挤出物具有相互分离的微区域，其宏观地对准在平行，垂直，横向或其组合。 挤出后，该方法任选地包括拉伸和凝结挤出物的步骤。