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公开(公告)号：US11235132B2
公开(公告)日：2022-02-01
申请号：US16471907
申请日：2017-12-20
Applicant: Ohio State Innovation Foundation
Inventor： Daniel Gallego-Perez , Natalia Higuita-Castro , Lingqian Chang , Chandan Sen
IPC: A61M37/00
Abstract: Provided herein are devices and methods for topically and controllably delivering cargo across or into biological tissues, particularly the skin. These devices permit delivery of cargo to deeper cell layers of a tissue. These devices include microstructure arrays comprising nanochannels. Also disclosed is a device comprising a one or more microstructure arrays encased in a frame.
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公开(公告)号：US10251861B2
公开(公告)日：2019-04-09
申请号：US14406403
申请日：2013-06-07
Applicant: Ohio State Innovation Foundation
Inventor： Chandan Sen , Sashwati Roy , Savita Khanna , Cameron Rink
IPC: A61K31/353 , A61K36/88 , A61K36/889 , A61K36/899 , A61K36/8998
Abstract: The present invention provides methods to improve scar and burn outcome utilizing tocotrienols. In particular, various skin pathologies may be treated using the present methods. The present invention also provides methods to increase skin tissue concentrations of tocotrienols.
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公开(公告)号：US11518790B2
公开(公告)日：2022-12-06
申请号：US16471808
申请日：2017-12-20
Applicant: Ohio State Innovation Foundation
Inventor： Daniel Gallego-Perez , Ly James Lee , Durba Pal , Subhadip Ghatak , Chandan Sen
Abstract: Disclosed herein are compositions and methods that involve using compositions containing one or more of ETV2, FOXC2, FLI1 and a miR-200b inhibitor for directly reprogramming somatic cells into induced vasculogenic cells both in vitro and in vivo. These compositions and methods are useful for a variety of purposes, including the development of pro-angiogenic therapies.
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公开(公告)号：US20210340561A1
公开(公告)日：2021-11-04
申请号：US17259766
申请日：2019-08-01
Applicant: Ohio State Innovation Foundation
Inventor： Daniel Gallego Perez , Chandan Sen , Natalia Higuita Castro
Abstract: Disclosed herein are compositions and methods that involve using compositions for directly reprogramming skin cells into insulin-producing cells both in vitro and in vivo. These compositions and methods are useful for a variety of purposes, including the treatment of insulin-dependent and insulin-resistant diabetes. Therefore, also disclosed is a method for treating diabetes in a subject that involves reprogramming an effective amount of skin cells in the subject into an insulin producing cell using the method disclosed herein.
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公开(公告)号：US20210332106A1
公开(公告)日：2021-10-28
申请号：US17284286
申请日：2019-10-18
Applicant: Ohio State Innovation Foundation
Inventor： Natalia Higuita-Castro , Daniel Gallego-Perez , Samir Ghadiali , Joshua Englert , Chandan Sen
IPC: C07K14/785 , C12N15/88 , A61K38/17 , A61K9/51 , A61P11/00
Abstract: Disclosed are lung-targeted extracellular vesicles (EVs) loaded with an anti-inflammatory cargo, as well as compositions, systems, and methods for making same. The disclosed EVs can contain a lung targeted ligand, such as a fusion protein containing a lung targeting moiety. Also disclosed is a composition comprising an EV containing the disclosed fusion protein. In some embodiments, the EV is loaded with an anti-inflammatory cargo. Also disclosed is an EV-producing cell engineered to produce the disclosed EVs. Also disclosed is a method for making the disclosed EVs that involves culturing the disclosed EV-producing cells under conditions suitable to produce EVs.
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Patent Agency Ranking
公开(公告)号：US20220134073A1
公开(公告)日：2022-05-05
申请号：US17548011
申请日：2022-01-18
Applicant: Ohio State Innovation Foundation
Inventor： Daniel Gallego-Perez , Natalia Higuita-Castro , Lingqian Chang , Chandan Sen
Abstract: Provided herein are devices and methods for topically and controllably delivering cargo or collecting samples into or from biological tissues, particularly the skin. These devices permit delivery of cargo and collection of samples from cell layers deep within a tissue. These devices include microstructure arrays comprising nanochannels. Also disclosed is a device comprising a one or more microstructure arrays encased in a frame.
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公开(公告)号：US20190329014A1
公开(公告)日：2019-10-31
申请号：US16471907
申请日：2017-12-20
Applicant: Ohio State Innovation Foundation
Inventor： Daniel Gallego-Perez , Chandan Sen , Natalia Higuita-Castro , Lingqian Chang
IPC: A61M37/00
Abstract: Provided herein are devices and methods for topically and controllably delivering cargo across or into biological tissues, particularly the skin. These devices permit delivery of cargo to deeper cell layers of a tissue. These devices include microstructure arrays comprising nanochannels. Also disclosed is a device comprising a one or more microstructure arrays encased in a frame.
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公开(公告)号：US12221471B2
公开(公告)日：2025-02-11
申请号：US17284286
申请日：2019-10-18
Applicant: Ohio State Innovation Foundation
Inventor： Natalia Higuita-Castro , Daniel Gallego-Perez , Samir Ghadiali , Joshua Englert , Chandan Sen
IPC: C07K14/785 , A61K9/51 , A61K38/17 , A61P11/00 , C12N15/88
Abstract: Disclosed are lung-targeted extracellular vesicles (EVs) loaded with an anti-inflammatory cargo, as well as compositions, systems, and methods for making same. The disclosed EVs can contain a lung targeted ligand, such as a fusion protein containing a lung targeting moiety. Also disclosed is a composition comprising an EV containing the disclosed fusion protein. In some embodiments, the EV is loaded with an anti-inflammatory cargo. Also disclosed is an EV-producing cell engineered to produce the disclosed EVs. Also disclosed is a method for making the disclosed EVs that involves culturing the disclosed EV-producing cells under conditions suitable to produce EVs.
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公开(公告)号：US11578107B2
公开(公告)日：2023-02-14
申请号：US16471808
申请日：2017-12-20
Applicant: Ohio State Innovation Foundation
Inventor： Daniel Gallego-Perez , Ly James Lee , Durba Pal , Subhadip Ghatak , Chandan Sen
Abstract: Disclosed herein are compositions and methods that involve using compositions containing one or more of ETV2, FOXC2, FLI1 and a miR-200b inhibitor for directly reprogramming somatic cells into induced vasculogenic cells both in vitro and in vivo. These compositions and methods are useful for a variety of purposes, including the development of pro-angiogenic therapies.
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公开(公告)号：US11411227B2
公开(公告)日：2022-08-09
申请号：US16490789
申请日：2018-03-02
Applicant: OHIO STATE INNOVATION FOUNDATION
Inventor： Shaurya Prakash , Vishwanath V. Subramaniam , Chandan Sen , Asimina Kiourti , Shomita Steiner , Piya Das Ghatak , Ramandeep Vilkhu , Anne Co , Wesley Joo-Chen Thio
IPC: A61F13/00 , A61L15/44 , D03D1/00 , D06M11/83 , H01M4/06 , H01M4/38 , H01M4/54 , H01M50/411 , H01M50/44 , H01M6/04 , A41D1/00 , A41D31/12
Abstract: Disclosed and described herein are systems and methods of energy generation from fabric electrochemistry. An electrical cell is created when electrodes (cathodes and anodes) are ‘printed’ on or otherwise embedded into fabrics to generate DC power when moistened by a conductive bodily liquid such as sweat, wound, fluid, etc. The latter acts, in turn, as the cell's electrolyte. A singular piece of fabric can be configured into multiple cells by dividing regions of the fabric with hydrophobic barriers and having at least one anode-cathode set in each region. Flexible inter-connections between the cells can be used to scale the generated power, per the application requirements.
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