公开(公告)号：US11179322B2

公开(公告)日：2021-11-23

申请号：US16506008

申请日：2019-07-09

申请人： Novocure GmbH

发明人： Karnit Gotlib ,  Einav Zeevi ,  Rosa S. Schnaiderman ,  Tali Voloshin-Sela ,  Moshe Giladi ,  Adrian Kinzel ,  Eilon Kirson ,  Uri Weinberg ,  Yoram Palti ,  Shiri Davidi

IPC分类号： A61N1/20 ,  A61K31/4418 ,  A61K9/00 ,  A61P35/00

摘要： Viability of cancer cells (e.g., hepatocellular carcinoma cells) can be reduced by administering sorafenib to the cancer cells and applying an alternating electric field with a frequency between 100 and 400 kHz to the cancer cells. Viability of cancer cells (e.g., hepatocellular carcinoma cells) disposed in a body of a living subject can be reduced by administering sorafenib to the subject and applying an alternating electric field with a frequency between 100 and 400 kHz to the cancer cells. Notably, experiments show that the combination of sorafenib and the alternating electric field produces synergistic results both in vitro and in vivo.

公开(公告)号：US11642514B2

公开(公告)日：2023-05-09

申请号：US17190979

申请日：2021-03-03

申请人： Novocure GmbH

发明人： Yoram Wasserman ,  Cornelia Wenger ,  Pedro Michael Cavaleiro Miranda ,  Zeev Bomzon ,  Noa Urman ,  Eilon Kirson ,  Yoram Palti

IPC分类号： A61B5/05 ,  A61B5/053 ,  A61B5/055 ,  A61B5/24 ,  A61B5/316 ,  A61B5/00 ,  A61N1/40 ,  G16H50/50 ,  A61N1/04 ,  A61N1/36 ,  G16Z99/00 ,  A61N1/32

CPC分类号： A61N1/0456 ,  A61B5/0042 ,  A61B5/05 ,  A61B5/053 ,  A61B5/055 ,  A61B5/24 ,  A61B5/316 ,  A61B5/4064 ,  A61N1/0476 ,  A61N1/32 ,  A61N1/36002 ,  A61N1/36025 ,  A61N1/40 ,  G16H50/50 ,  G16Z99/00

摘要： When electrodes are used to impose an electric field in target tissue within an anatomic volume (e.g., to apply TTFields to treat a tumor), the position of the electrodes can be optimized by generating a 3D map of electrical conductivity or resistivity of the anatomic volume. A location of the target tissue within the anatomic volume is identified, and a dipole is added to the 3D map at a location that corresponds to the target tissue. positions for the electrodes that maximize a potential attributable to the dipole are determined based on the 3D map of electrical conductivity or resistivity and the location of the dipole.

公开(公告)号：US11701161B2

公开(公告)日：2023-07-18

申请号：US17023990

申请日：2020-09-17

申请人： Novocure GmbH

发明人： Yoram Palti ,  Matan Dishon

IPC分类号： A61B18/12 ,  A61B5/0536 ,  A61B90/00 ,  A61B18/00 ,  A61B18/14

CPC分类号： A61B18/12 ,  A61B5/0536 ,  A61B18/1206 ,  A61B90/37 ,  A61B2018/00732 ,  A61B2018/00875 ,  A61B2018/124 ,  A61B2018/128 ,  A61B2018/147 ,  A61B2090/374 ,  A61B2090/3762 ,  A61B2576/00

摘要： Tumors can be treated with an alternating electric field. The size of cells in the tumor is determined prior to the start of treatment by, for example, biopsy or by inverse electric impedance tomography. A treatment frequency is chosen based on the determined cell size. The cell size can be determined during the course of treatment and the treatment frequency is adjusted to reflect changes in the cell size. A suitable apparatus for this purpose includes a device for measuring the tumor impedance, an AC signal generator with a controllable output frequency, a processor for estimating the size of tumor cells and setting the frequency of the AC signal generator based thereon, and at least one pair of electrodes operatively connected to the AC signal generator such that an alternating electric field is applied to the tumor.

公开(公告)号：US11879886B2

公开(公告)日：2024-01-23

申请号：US18092742

申请日：2023-01-03

申请人： Novocure GmbH

发明人： Moshe Giladi ,  Yoram Wasserman ,  Yoram Palti ,  Michael Krinitsky ,  Michael Shtotland

IPC分类号： G01N33/483 ,  G01N15/14 ,  F21V8/00 ,  G01N33/574 ,  G02B21/34 ,  G02B21/00

CPC分类号： G01N33/4836 ,  G01N33/574 ,  G02B21/34 ,  G02B21/0088

摘要： An apparatus includes a bottom panel with a transparent region and ceramic sidewalls affixed to the bottom panel to form a container. Electrodes are disposed on the outer surface of the sidewalls at positions selected so that when a sample is positioned in the container, applying a voltage between the electrodes induces an electric field through the sample. Electrical conductors provide contact with the electrodes. All the components are sized and shaped to facilitate positioning of the container on the stage of an inverted microscope so that when the sample is positioned in the container, light emanating from a light source is free to travel along an optical path that passes through the sample, through the transparent region, and into the objective of the inverted microscope. The electrodes and conductors are positioned with respect to the transparent region so as not to interfere with the optical path.