公开(公告)号：US11554262B2

公开(公告)日：2023-01-17

申请号：US16800737

申请日：2020-02-25

申请人： Novocure GmbH

发明人： Moshe Giladi ,  Einav Zeevi ,  Cornelia Wenger ,  Zeev Bomzon

IPC分类号： A61N1/36 ,  G01N27/22 ,  G01N27/447 ,  G01N33/483 ,  G01N33/487 ,  A61B5/053 ,  A61N1/40

摘要： Cancer treatment using TTFields (Tumor Treating Fields) can be customized to each individual subject by obtaining cancer cells from the subject, determining an electrical characteristic (e.g., dielectrophoretic forces, cell membrane capacitance, etc.) of the cancer cells, determining a frequency for the TTFields based on the determined electrical characteristic, and treating the cancer by applying TTFields to the subject at the determined frequency. In addition, cancer treatment can be planned for each individual subject by obtaining cancer cells from the subject, determining an electrical characteristic of the cancer cells, predicting whether TTFields would be effective to treat the cancer based on the determined electrical characteristic, and treating the subject by applying TTFields if the prediction indicates that TTFields would be effective.

公开(公告)号：US11179322B2

公开(公告)日：2021-11-23

申请号：US16506008

申请日：2019-07-09

申请人： Novocure GmbH

发明人： Karnit Gotlib ,  Einav Zeevi ,  Rosa S. Schnaiderman ,  Tali Voloshin-Sela ,  Moshe Giladi ,  Adrian Kinzel ,  Eilon Kirson ,  Uri Weinberg ,  Yoram Palti ,  Shiri Davidi

IPC分类号： A61N1/20 ,  A61K31/4418 ,  A61K9/00 ,  A61P35/00

摘要： Viability of cancer cells (e.g., hepatocellular carcinoma cells) can be reduced by administering sorafenib to the cancer cells and applying an alternating electric field with a frequency between 100 and 400 kHz to the cancer cells. Viability of cancer cells (e.g., hepatocellular carcinoma cells) disposed in a body of a living subject can be reduced by administering sorafenib to the subject and applying an alternating electric field with a frequency between 100 and 400 kHz to the cancer cells. Notably, experiments show that the combination of sorafenib and the alternating electric field produces synergistic results both in vitro and in vivo.