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公开(公告)号：US11013696B2
公开(公告)日：2021-05-25
申请号：US16537934
申请日：2019-08-12
申请人： Novartis AG
发明人： Luis Brito , Delai Chen , Gabriel Grant Gamber , Andrew Geall , Kevin Love , Thomas Zabawa , Frederic Zecri
IPC分类号： C07D319/06 , C07C219/06 , C07C229/12 , C07D207/12 , C07D207/16 , C07D211/22 , C07D211/62 , C07C323/52 , A61K31/7105 , A61K31/713 , C07C219/16 , C07D233/60 , C07D295/088 , C12N15/88 , A61K9/51 , A61K9/127 , A61K47/18 , A61K38/18 , A61K38/22 , A61K39/12 , C07C235/08 , C07D211/06 , C07D211/46 , C07D233/64 , C07D295/13 , C12N7/00 , C12N15/113 , A61K39/00
摘要： This invention provides for a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein R1-R3, n, p, L1 and L2 are defined herein. The compounds of formula (I) and pharmaceutically acceptable salts thereof are cationic lipids useful in the delivery of biologically active agents to cells and tissues.
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公开(公告)号：US11420933B2
公开(公告)日：2022-08-23
申请号：US17104294
申请日：2020-11-25
申请人： Novartis AG
发明人： Luis Brito , Delai Chen , Gabriel Gamber , Andrew Geall , Kevin Love , Thomas Zabawa , Frederic Zecri
IPC分类号： C07C229/12 , A61K47/18 , C07C229/38 , C07D205/04 , C07D265/30 , C07D207/12 , C07D207/16 , C07D211/22 , C07D295/088 , C07D211/46 , C07D211/60 , C07D211/62 , C07D295/15 , C07C271/20 , C07C219/04 , A61K9/127 , A61K9/51 , A61K31/7105 , A61K31/713 , A61K39/12 , A61K39/39 , C07C271/22 , C07D211/06 , C07D211/34 , C07D211/44 , A61K39/00
摘要： This invention provides for a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein R1-R4, L1, n and p are defined herein. The compounds of formula (X) and pharmaceutically acceptable salts thereof are cationic lipids useful in the delivery of biologically active agents to cells and tissues.
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公开(公告)号：US20180369386A1
公开(公告)日：2018-12-27
申请号：US16115883
申请日：2018-08-29
申请人： Novartis AG
发明人： Jeremy Lee Baryza , Rohan Eric John Beckwith , Keith Bowman , Crystal Byers , Tanzina Fazal , Gabriel Grant Gamber , Cameron Chuck-Munn Lee , Ritesh Bhanudasji Tichkule , Chandra Vargeese , Shuangxi Wang , Laura West , Thomas Zabawa , Junping Zhao
IPC分类号： A61K47/18 , C07C229/14 , A61K9/127 , A61K9/51 , C12N15/113 , C07D317/28 , C07D295/096 , C07D213/79 , C07D213/69 , C07D205/04 , C07C235/42 , A61K9/00 , C07C229/12 , C07C219/06 , C07C217/58 , A61K47/22 , A61K38/22 , A61K31/713 , A61K48/00
摘要： This invention provides for a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein R1-R4, L and X are defined herein. The compounds of formula (I) and pharmaceutically acceptable salts thereof are cationic lipids useful in the delivery of biologically active agents to cells and tissues.
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公开(公告)号：US10906867B2
公开(公告)日：2021-02-02
申请号：US16013048
申请日：2018-06-20
申请人： Novartis AG
发明人： Luis Brito , Delai Chen , Gabriel Grant Gamber , Andrew Geall , Kevin Love , Thomas Zabawa , Frederic Zecri
IPC分类号： C07C229/12 , C07C229/38 , C07D205/04 , C07D265/30 , C07D207/12 , C07D207/16 , C07D211/22 , C07D295/088 , C07D211/46 , C07D211/60 , C07D211/62 , C07D295/15 , C07C271/20 , C07C219/04 , A61K47/18 , A61K9/127 , A61K9/51 , A61K31/7105 , A61K31/713 , A61K39/12 , A61K39/39 , C07C271/22 , C07D211/06 , C07D211/34 , C07D211/44 , A61K39/00
摘要： This invention provides for a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein R1-R4, L1, n and p are defined herein. The compounds of formula (X) and pharmaceutically acceptable salts thereof are cationic lipids useful in the delivery of biologically active agents to cells and tissues.
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公开(公告)号：US10426737B2
公开(公告)日：2019-10-01
申请号：US15104723
申请日：2014-12-17
申请人： Novartis AG
发明人： Luis Brito , Delai Chen , Gabriel Grant Gamber , Andrew Geall , Kevin Love , Thomas Zabawa , Frederic Zecri
IPC分类号： C07C219/06 , C07C219/16 , C07C229/12 , C07C235/08 , C07C323/52 , A61K9/51 , C07D319/06 , C07D233/60 , C07D207/12 , C07D207/16 , C07D211/22 , C07D295/088 , C07D211/62 , A61K47/18 , A61K9/127 , A61K31/7105 , A61K31/713 , C12N15/88 , A61K38/18 , A61K38/22 , A61K39/12 , C07D211/06 , C07D211/46 , C07D233/64 , C07D295/13 , C12N7/00 , C12N15/113 , A61K39/00
摘要： This invention provides for a compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein R1-R3, n, p, L1 and L2 are defined herein. The compounds of formula (I) and pharmaceutically acceptable salts thereof are cationic lipids useful in the delivery of biologically active agents to cells and tissues.
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公开(公告)号：US10792361B2
公开(公告)日：2020-10-06
申请号：US16115883
申请日：2018-08-29
申请人： Novartis AG
发明人： Jeremy Lee Baryza , Rohan Eric John Beckwith , Keith Bowman , Crystal Byers , Tanzina Fazal , Gabriel Grant Gamber , Cameron Chuck-Munn Lee , Ritesh Bhanudasji Tichkule , Chandra Vargeese , Shuangxi Wang , Laura West , Thomas Zabawa , Junping Zhao
IPC分类号： A61K47/18 , A61K9/127 , A61K9/51 , A61K31/713 , C07C217/58 , C07C219/06 , C07C229/12 , C07D317/28 , C07D295/096 , A61K9/00 , A61K38/22 , A61K47/22 , C07C229/14 , C07C235/42 , C07D205/04 , C07D213/69 , C07D213/79 , C12N15/113 , A61K48/00
摘要： This invention provides for a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein R1-R4, L and X are defined herein. The compounds of formula (I) and pharmaceutically acceptable salts thereof are cationic lipids useful in the delivery of biologically active agents to cells and tissues.
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公开(公告)号：US10729775B2
公开(公告)日：2020-08-04
申请号：US16021193
申请日：2018-06-28
申请人： Novartis AG
发明人： Jeremy Lee Baryza , Rohan Eric John Beckwith , Keith Bowman , Crystal Byers , Tanzina Fazal , Gabriel Grant Gamber , Cameron Chuck-munn Lee , Ritesh Bhanudasji Tichkule , Chandra Vargeese , Shuangxi Wang , Laura Ellen West , Thomas Zabawa , Junping Zhao
IPC分类号： A61K47/18 , C12N15/113 , A61K47/22 , C07D213/79 , C07D317/24 , C07D317/28 , C07D205/04 , C07D295/096 , C07D213/69 , A61K9/127 , C07C217/58 , C07C217/60 , C07C217/62 , C07C219/22 , C07C219/28 , C07C229/12 , C07C235/46 , C07C237/08
摘要： This invention provides for a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein R1-R4, L and X are defined herein. The compounds of formula (I) and pharmaceutically acceptable salts thereof are cationic lipids useful in the delivery of biologically active agents to cells and tissues.
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公开(公告)号：US10124065B2
公开(公告)日：2018-11-13
申请号：US14779939
申请日：2014-03-06
申请人： Novartis AG
发明人： Jeremy Lee Baryza , Rohan Eric John Beckwith , Keith Bowman , Crystal Byers , Tanzina Fazal , Gabriel Grant Gamber , Cameron Chuck-Munn Lee , Ritesh Bhanudasji Tichkule , Chandra Vargeese , Shuangxi Wang , Laura West , Thomas Zabawa , Junping Zhao
IPC分类号： C07C211/00 , A61K9/00 , C07C217/00 , A61K47/22 , A61K47/18 , C07C217/58 , C07C219/06 , C07C229/12 , C07D317/28 , C07D295/096 , A61K9/127 , A61K9/51 , A61K31/713 , A61K38/22 , C07C229/14 , C07C235/42 , C07D205/04 , C07D213/69 , C07D213/79 , C12N15/113 , A61K48/00
摘要： This invention provides for a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein R1-R4, L and X are defined herein. The compounds of formula (I) and pharmaceutically acceptable salts thereof are cationic lipids useful in the delivery of biologically active agents to cells and tissues.
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公开(公告)号：US20180296677A1
公开(公告)日：2018-10-18
申请号：US16021193
申请日：2018-06-28
申请人： Novartis AG
发明人： Jeremy Lee Baryza , Rohan Eric John Beckwith , Keith Bowman , Crystal Byers , Tanzina Fazal , Gabriel Grant Gamber , Cameron Chuck-munn Lee , Ritesh Bhanudasji Tichkule , Chandra Vargeese , Shuangxi Wang , Laura Ellen West , Thomas Zabawa , Junping Zhao
IPC分类号： A61K47/18 , C07C235/46 , A61K9/127 , C12N15/113 , C07D317/28 , C07D317/24 , C07D295/096 , C07D213/79 , C07D213/69 , C07D205/04 , C07C237/08 , C07C229/12 , C07C219/28 , C07C219/22 , C07C217/62 , C07C217/60 , C07C217/58 , A61K47/22
摘要： This invention provides for a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein R1-R4, L and X are defined herein. The compounds of formula (I) and pharmaceutically acceptable salts thereof are cationic lipids useful in the delivery of biologically active agents to cells and tissues.
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公开(公告)号：US20180290965A1
公开(公告)日：2018-10-11
申请号：US16013048
申请日：2018-06-20
申请人： Novartis AG
发明人： Luis Brito , Delai Chen , Gabriel Grant Gamber , Andrew Geall , Kevin Love , Thomas Zabawa , Frederic Zecri
IPC分类号： C07C229/12 , C07D211/44 , A61K39/39 , C07C271/22 , C07D211/06 , A61K31/713 , A61K31/7105 , A61K9/51 , A61K9/127 , A61K47/18 , C07C219/04 , C07C271/20 , C07D295/15 , C07D211/62 , C07D211/60 , C07D211/46 , C07D295/088 , C07D211/22 , C07D207/16 , C07D207/12 , C07D265/30 , C07D205/04 , C07C229/38 , C07D211/34
摘要： This invention provides for a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein R1-R4, L1, n and p are defined herein. The compounds of formula (X) and pharmaceutically acceptable salts thereof are cationic lipids useful in the delivery of biologically active agents to cells and tissues.
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