公开(公告)号：US11053218B2

公开(公告)日：2021-07-06

申请号：US16835938

申请日：2020-03-31

申请人： Novartis AG

发明人： Rohan Eric John Beckwith ,  Simone Bonazzi ,  Artiom Cernijenko ,  Aleem Fazal ,  Ritesh Bhanudasji Tichkule ,  Michael Scott Visser

IPC分类号： C07D401/14 ,  A61K31/4412 ,  C07D401/04 ,  C07D407/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D487/08 ,  C07D495/04 ,  C07D513/04 ,  A61P35/00

摘要： The present disclosure provides a compound of Formula (I′): or a pharmaceutically acceptable salt, hydrate, solvate, prodrug, stereoisomer, or tautomer thereof, wherein R1, R2, Rx, X1, n, n1, and q are as defined herein, and methods of making and using same.

公开(公告)号：US10414755B2

公开(公告)日：2019-09-17

申请号：US16108713

申请日：2018-08-22

申请人： Novartis AG

发明人： Rohan Eric John Beckwith ,  Simone Bonazzi ,  Artiom Cernijenko ,  Aleem Fazal ,  Ritesh Bhanudasji Tichkule ,  Michael Scott Visser

IPC分类号： C07D401/14 ,  A61K31/4412 ,  A61P35/00 ,  C07D413/14 ,  C07D401/04 ,  C07D407/14 ,  C07D409/14 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D487/08 ,  C07D495/04 ,  C07D513/04

摘要： The present disclosure provides a compound of Formula (I′): or a pharmaceutically acceptable salt, hydrate, solvate, prodrug, stereoisomer, or tautomer thereof, wherein R1, R2, Rx, X1, n, n1, and q are as defined herein, and methods of making and using same.

公开(公告)号：US11185537B2

公开(公告)日：2021-11-30

申请号：US16504376

申请日：2019-07-08

申请人： Novartis AG

发明人： Rohan Eric John Beckwith ,  Simone Bonazzi ,  Artiom Cernijenko ,  Fupeng Ma ,  Nathaniel F. Ware

IPC分类号： C07D401/14 ,  A61K31/454 ,  A61P35/00 ,  A61K31/4545 ,  A61K31/498 ,  C07D401/04

摘要： The present disclosure provides a compound of Formula (I′): or a pharmaceutically acceptable salt, hydrate, solvate, prodrug, stereoisomer, or tautomer thereof, wherein Ra, Rb, Rx, R1, R2, X2, and q are as defined herein, and methods of making and using same.

公开(公告)号：US20210355115A1

公开(公告)日：2021-11-18

申请号：US17278163

申请日：2019-09-19

申请人： Novartis AG

发明人： Rohan Eric John Beckwith ,  Hua Jiang ,  Ce Wang

IPC分类号： C07D413/14 ,  A61P27/16

摘要： A compound of Formula (I) or or a pharmaceutically acceptable salt thereof, is provided that has been shown to be useful for treating hearing loss or balance disorder: Formula (I) wherein R1 and Y are as defined herein.

公开(公告)号：US11999802B2

公开(公告)日：2024-06-04

申请号：US16757026

申请日：2018-10-18

申请人： Novartis AG

发明人： James E. Bradner ,  Andrei Golosov ,  Carleton Proctor Goold ,  Carla Patricia Pinto Guimaraes ,  Marc Horst Peter Hild ,  Gregory Motz ,  Nathan Thomas Ross ,  Jonathan M. Solomon ,  Rohan Eric John Beckwith ,  Seth Carbonneau

IPC分类号： C07K19/00 ,  A61K31/4545 ,  A61K31/46 ,  A61K35/12 ,  C07D209/48 ,  C07D213/81 ,  C07D401/14 ,  C07D451/02 ,  C07K14/435 ,  C07K14/705 ,  C07K14/725 ,  C07K16/18 ,  C07K16/28 ,  C12N9/06 ,  C12N15/63 ,  C12N15/86 ,  G01N33/68

CPC分类号： C07K19/00 ,  A61K31/4545 ,  A61K31/46 ,  A61K35/12 ,  C07D209/48 ,  C07D213/81 ,  C07D401/14 ,  C07D451/02 ,  C07K14/435 ,  C07K14/705 ,  C07K14/7051 ,  C07K14/70521 ,  C07K14/70575 ,  C07K16/18 ,  C07K16/2803 ,  C07K16/2815 ,  C07K16/2863 ,  C07K16/2875 ,  C07K16/2887 ,  C07K16/2896 ,  C12N9/003 ,  C12N15/63 ,  C12N15/86 ,  C12Y105/01003 ,  G01N33/6803 ,  C07K2317/622 ,  C07K2319/02 ,  C07K2319/03 ,  C07K2319/20 ,  C07K2319/35 ,  C07K2319/81 ,  C07K2319/95 ,  C12N2740/15043

摘要： The invention provides compositions including a fusion polypeptide and methods for making a fusion polypeptide that includes a COF1/CRBN-binding polypeptide, COF2/CRBN-binding polypeptide, or COF3/CRBN-binding polypeptide and a heterologous polypeptide of interest.

公开(公告)号：US20200339704A1

公开(公告)日：2020-10-29

申请号：US16757026

申请日：2018-10-18

申请人： James E. BRADNER ,  Novartis AG

发明人： James E. Bradner ,  Andrei Golosov ,  Carleton Proctor Goold ,  Carla Patricia Pinto Guimaraes ,  Marc Horst Peter Hild ,  Gregory Motz ,  Nathan Thomas Ross ,  Jonathan M. Solomon ,  Rohan Eric John Beckwith ,  Seth Carbonneau

IPC分类号： C07K19/00 ,  C07K16/18 ,  C12N9/06 ,  C07K14/725 ,  C07K14/705 ,  C07K16/28 ,  G01N33/68 ,  C12N15/86 ,  A61K35/12 ,  A61K31/4545 ,  C07D401/14 ,  C07D451/02 ,  A61K31/46

摘要： The invention provides compositions including a fusion polypeptide and methods for making a fusion polypeptide that includes a COF1/CRBN-binding polypeptide, COF2/CRBN-binding polypeptide, or COF3/CRBN-binding polypeptide and a heterologous polypeptide of interest.

公开(公告)号：US20180369386A1

公开(公告)日：2018-12-27

申请号：US16115883

申请日：2018-08-29

申请人： Novartis AG

发明人： Jeremy Lee Baryza ,  Rohan Eric John Beckwith ,  Keith Bowman ,  Crystal Byers ,  Tanzina Fazal ,  Gabriel Grant Gamber ,  Cameron Chuck-Munn Lee ,  Ritesh Bhanudasji Tichkule ,  Chandra Vargeese ,  Shuangxi Wang ,  Laura West ,  Thomas Zabawa ,  Junping Zhao

IPC分类号： A61K47/18 ,  C07C229/14 ,  A61K9/127 ,  A61K9/51 ,  C12N15/113 ,  C07D317/28 ,  C07D295/096 ,  C07D213/79 ,  C07D213/69 ,  C07D205/04 ,  C07C235/42 ,  A61K9/00 ,  C07C229/12 ,  C07C219/06 ,  C07C217/58 ,  A61K47/22 ,  A61K38/22 ,  A61K31/713 ,  A61K48/00

摘要： This invention provides for a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein R1-R4, L and X are defined herein. The compounds of formula (I) and pharmaceutically acceptable salts thereof are cationic lipids useful in the delivery of biologically active agents to cells and tissues.

公开(公告)号：US11833142B2

公开(公告)日：2023-12-05

申请号：US17493055

申请日：2021-10-04

申请人： Novartis AG

发明人： Rohan Eric John Beckwith ,  Simone Bonazzi ,  Artiom Cernijenko ,  Fupeng Ma ,  Nathaniel F. Ware

IPC分类号： A61K31/454 ,  A61P35/00 ,  A61K31/4545 ,  A61K31/498 ,  C07D401/04 ,  C07D401/14

CPC分类号： A61K31/454 ,  A61K31/4545 ,  A61K31/498 ,  A61P35/00 ,  C07D401/04 ,  C07D401/14

摘要： The present disclosure provides a compound of Formula (I′):






or a pharmaceutically acceptable salt, hydrate, solvate, prodrug, stereoisomer, or tautomer thereof, wherein Ra, Rb, Rx, R1, R2, X2, and q are as defined herein, and methods of making and using same.

公开(公告)号：US10792361B2

公开(公告)日：2020-10-06

申请号：US16115883

申请日：2018-08-29

申请人： Novartis AG

发明人： Jeremy Lee Baryza ,  Rohan Eric John Beckwith ,  Keith Bowman ,  Crystal Byers ,  Tanzina Fazal ,  Gabriel Grant Gamber ,  Cameron Chuck-Munn Lee ,  Ritesh Bhanudasji Tichkule ,  Chandra Vargeese ,  Shuangxi Wang ,  Laura West ,  Thomas Zabawa ,  Junping Zhao

IPC分类号： A61K47/18 ,  A61K9/127 ,  A61K9/51 ,  A61K31/713 ,  C07C217/58 ,  C07C219/06 ,  C07C229/12 ,  C07D317/28 ,  C07D295/096 ,  A61K9/00 ,  A61K38/22 ,  A61K47/22 ,  C07C229/14 ,  C07C235/42 ,  C07D205/04 ,  C07D213/69 ,  C07D213/79 ,  C12N15/113 ,  A61K48/00

摘要： This invention provides for a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein R1-R4, L and X are defined herein. The compounds of formula (I) and pharmaceutically acceptable salts thereof are cationic lipids useful in the delivery of biologically active agents to cells and tissues.

公开(公告)号：US10729775B2

公开(公告)日：2020-08-04

申请号：US16021193

申请日：2018-06-28

申请人： Novartis AG

发明人： Jeremy Lee Baryza ,  Rohan Eric John Beckwith ,  Keith Bowman ,  Crystal Byers ,  Tanzina Fazal ,  Gabriel Grant Gamber ,  Cameron Chuck-munn Lee ,  Ritesh Bhanudasji Tichkule ,  Chandra Vargeese ,  Shuangxi Wang ,  Laura Ellen West ,  Thomas Zabawa ,  Junping Zhao

IPC分类号： A61K47/18 ,  C12N15/113 ,  A61K47/22 ,  C07D213/79 ,  C07D317/24 ,  C07D317/28 ,  C07D205/04 ,  C07D295/096 ,  C07D213/69 ,  A61K9/127 ,  C07C217/58 ,  C07C217/60 ,  C07C217/62 ,  C07C219/22 ,  C07C219/28 ,  C07C229/12 ,  C07C235/46 ,  C07C237/08

摘要： This invention provides for a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein R1-R4, L and X are defined herein. The compounds of formula (I) and pharmaceutically acceptable salts thereof are cationic lipids useful in the delivery of biologically active agents to cells and tissues.