专利检索 ap:("Novartis AG") AND inv:"Nathan Thomas Ross" 第 1 页

1.

发明授权
Compositions and methods for selective protein degradation 有权

公开(公告)号：US11999802B2

公开(公告)日：2024-06-04

申请号：US16757026

申请日：2018-10-18

申请人： Novartis AG

发明人： James E. Bradner , Andrei Golosov , Carleton Proctor Goold , Carla Patricia Pinto Guimaraes , Marc Horst Peter Hild , Gregory Motz , Nathan Thomas Ross , Jonathan M. Solomon , Rohan Eric John Beckwith , Seth Carbonneau

IPC分类号： C07K19/00 , A61K31/4545 , A61K31/46 , A61K35/12 , C07D209/48 , C07D213/81 , C07D401/14 , C07D451/02 , C07K14/435 , C07K14/705 , C07K14/725 , C07K16/18 , C07K16/28 , C12N9/06 , C12N15/63 , C12N15/86 , G01N33/68

CPC分类号： C07K19/00 , A61K31/4545 , A61K31/46 , A61K35/12 , C07D209/48 , C07D213/81 , C07D401/14 , C07D451/02 , C07K14/435 , C07K14/705 , C07K14/7051 , C07K14/70521 , C07K14/70575 , C07K16/18 , C07K16/2803 , C07K16/2815 , C07K16/2863 , C07K16/2875 , C07K16/2887 , C07K16/2896 , C12N9/003 , C12N15/63 , C12N15/86 , C12Y105/01003 , G01N33/6803 , C07K2317/622 , C07K2319/02 , C07K2319/03 , C07K2319/20 , C07K2319/35 , C07K2319/81 , C07K2319/95 , C12N2740/15043

摘要： The invention provides compositions including a fusion polypeptide and methods for making a fusion polypeptide that includes a COF1/CRBN-binding polypeptide, COF2/CRBN-binding polypeptide, or COF3/CRBN-binding polypeptide and a heterologous polypeptide of interest.

2.

发明申请
COMPOSITIONS AND METHODS FOR SELECTIVE PROTEIN DEGRADATION 审中-公开

公开(公告)号：US20200339704A1

公开(公告)日：2020-10-29

申请号：US16757026

申请日：2018-10-18

申请人： James E. BRADNER , Novartis AG

发明人： James E. Bradner , Andrei Golosov , Carleton Proctor Goold , Carla Patricia Pinto Guimaraes , Marc Horst Peter Hild , Gregory Motz , Nathan Thomas Ross , Jonathan M. Solomon , Rohan Eric John Beckwith , Seth Carbonneau

IPC分类号： C07K19/00 , C07K16/18 , C12N9/06 , C07K14/725 , C07K14/705 , C07K16/28 , G01N33/68 , C12N15/86 , A61K35/12 , A61K31/4545 , C07D401/14 , C07D451/02 , A61K31/46

摘要： The invention provides compositions including a fusion polypeptide and methods for making a fusion polypeptide that includes a COF1/CRBN-binding polypeptide, COF2/CRBN-binding polypeptide, or COF3/CRBN-binding polypeptide and a heterologous polypeptide of interest.