- 专利标题: Compositions and methods for selective protein degradation
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申请号: US16757026申请日: 2018-10-18
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公开(公告)号: US11999802B2公开(公告)日: 2024-06-04
- 发明人: James E. Bradner , Andrei Golosov , Carleton Proctor Goold , Carla Patricia Pinto Guimaraes , Marc Horst Peter Hild , Gregory Motz , Nathan Thomas Ross , Jonathan M. Solomon , Rohan Eric John Beckwith , Seth Carbonneau
- 申请人: Novartis AG
- 申请人地址: CH Basel
- 专利权人: Novartis AG
- 当前专利权人: Novartis AG
- 当前专利权人地址: CH Basel
- 代理机构: K&L Gates LLP
- 国际申请: PCT/US2018/056472 2018.10.18
- 国际公布: WO2019/079569A 2019.04.25
- 进入国家日期: 2020-04-17
- 主分类号: C07K19/00
- IPC分类号: C07K19/00 ; A61K31/4545 ; A61K31/46 ; A61K35/12 ; C07D209/48 ; C07D213/81 ; C07D401/14 ; C07D451/02 ; C07K14/435 ; C07K14/705 ; C07K14/725 ; C07K16/18 ; C07K16/28 ; C12N9/06 ; C12N15/63 ; C12N15/86 ; G01N33/68
摘要:
The invention provides compositions including a fusion polypeptide and methods for making a fusion polypeptide that includes a COF1/CRBN-binding polypeptide, COF2/CRBN-binding polypeptide, or COF3/CRBN-binding polypeptide and a heterologous polypeptide of interest.
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