CHIP FOR QUANTITATIVE DETECTION OF NEUTRALIZING ANTIBODY AND MANUFACTURING METHOD THEREOF

    公开(公告)号:US20240019428A1

    公开(公告)日:2024-01-18

    申请号:US18052321

    申请日:2022-11-03

    Abstract: The present invention provides a detection chip for quantitative detection of neutralizing antibody and manufacturing method thereof. A sensing layer is disposed on a circuit layer. A shielding layer corresponds a shielding part on the sensing layer to form a sensing area. The surface of the sensing area is hydroxylated to form a self-assembled monolayer film including the aldehyde group. A protein solution is dripped on the sensing area. An external electric field is applied to the sensing layer at an external angle with respect to the normal of the substrate to deflect protein molecules in the protein solution correspondingly. This structure can be applied to rapid and quantitative detection. According to various embodiments of the present invention, the sensing efficiency of the detection chip can be enhanced.

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