公开(公告)号：US20140371445A1

公开(公告)日：2014-12-18

申请号：US13916665

申请日：2013-06-13

Applicant: NATIONAL APPLIED RESEARCH LABORATORIES

Inventor： HUEIH-MIN CHEN ,  CHUNG-MING SUN ,  CHIH-YU HUANG

IPC: C07D317/72

CPC classification number: C07D317/72 ,  C07D317/46 ,  C07D401/12

Abstract: The present invention relates to a quinic acid derivative, preparation process of the same and pharmaceutical uses thereof. The quinic acid derivative has a quinic acid-like structure which binds to CD28, blocks T-cell signal 2 pathway via CD28, and suppresses T-cell activation. The C-1 carboxyl group, the C-3 hydroxyl group and the C-4 hydroxyl group of quinic acid are modified to attenuate the cytotoxicity of the quinic acid derivative. The preparation process of the quinic acid derivative comprises 2 steps of: treating quinic acid with the first reagent in the presence of the acid catalyst to form an immediate; and treating the immediate with the second reagent to from the quinic acid derivative. With the ability to suppress T-cell activation, the quinic acid derivative is used to treats an autoimmune disease, an allergy, transplant rejection or other related immune disorder.

Abstract translation: 本发明涉及一种奎尼酸衍生物，其制备方法及其药物用途。 奎宁酸衍生物具有与CD28结合的奎酸类结构，通过CD28阻断T细胞信号2途径，并抑制T细胞活化。 修饰了C-1羧基，C-3羟基和奎尼酸C-4羟基，以减弱奎尼酸衍生物的细胞毒性。 奎尼酸衍生物的制备方法包括以下步骤：在酸催化剂存在下用第一试剂处理奎尼酸以立即形成; 并用第二试剂立即从奎尼酸衍生物处理。 利用抑制T细胞活化的能力，奎宁酸衍生物用于治疗自身免疫性疾病，过敏症，移植排斥反应或其他相关免疫疾病。

公开(公告)号：US20240019428A1

公开(公告)日：2024-01-18

申请号：US18052321

申请日：2022-11-03

Applicant: NATIONAL APPLIED RESEARCH LABORATORIES

Inventor： HUEIH-MIN CHEN ,  CHIH-CHAO YANG ,  CHIH-YU HUANG

IPC: G01N33/543

CPC classification number: G01N33/54393 ,  G01N33/5438 ,  G01N33/5436 ,  G01N2610/00 ,  G01N2333/165

Abstract: The present invention provides a detection chip for quantitative detection of neutralizing antibody and manufacturing method thereof. A sensing layer is disposed on a circuit layer. A shielding layer corresponds a shielding part on the sensing layer to form a sensing area. The surface of the sensing area is hydroxylated to form a self-assembled monolayer film including the aldehyde group. A protein solution is dripped on the sensing area. An external electric field is applied to the sensing layer at an external angle with respect to the normal of the substrate to deflect protein molecules in the protein solution correspondingly. This structure can be applied to rapid and quantitative detection. According to various embodiments of the present invention, the sensing efficiency of the detection chip can be enhanced.

公开(公告)号：US20160310928A1

公开(公告)日：2016-10-27

申请号：US14753131

申请日：2015-06-29

Applicant: NATIONAL APPLIED RESEARCH LABORATORIES

Inventor： HUEIH-MIN CHEN ,  WEI-JEN WU ,  HSUAN-YU HUANG

IPC: B01J19/08

CPC classification number: B01J19/087 ,  B01J19/0046 ,  B01J2219/00488 ,  B01J2219/00527 ,  B01J2219/00596 ,  B01J2219/00637 ,  B01J2219/00693 ,  B01J2219/00725 ,  G01N33/6803

Abstract: A method for performance optimization of protein chips produced under an external electric field applied in different directions and a device that provides the external electric field in different directions are revealed. Firstly a plurality of protein chips is produced under an external electric field applied in different directions. Then a binding force between protein molecule on the protein chip and a ligand is measured and compared. Thus an angle of the external electric field applied that achieves performance optimization while using the protein molecule to produce the protein chips is found out. The device providing the external electric field in different directions includes a rotatable electric field support rotating around a carrier used for loading the protein chips. The electric field support is disposed with electrodes for providing the protein chips on the carrier the external electric field in different directions.

Abstract translation: 揭示了在不同方向施加的外部电场下产生的蛋白质芯片的性能优化方法以及在不同方向上提供外部电场的装置。 首先在不同方向施加的外部电场产生多个蛋白质芯片。 然后测量和比较蛋白质芯片上的蛋白质分子与配体之间的结合力。 因此，发现在使用蛋白质分子产生蛋白质芯片时实现性能优化的所施加的外部电场的角度。 在不同方向提供外部电场的装置包括围绕用于装载蛋白质芯片的载体旋转的可旋转的电场支持。 电场支持设置有用于在载体上将不同方向的外部电场提供蛋白质芯片的电极。