公开(公告)号：US20250043081A1

公开(公告)日：2025-02-06

申请号：US18717280

申请日：2022-12-05

Applicant: NORTHWESTERN UNIVERSITY

Inventor： Chad A. Mirkin ,  Max Everett Distler ,  Ho Fung Cheng ,  Kyle Joseph Gibson

IPC: C08G83/00 ,  C12N15/11

Abstract: The present disclosure is directed to multicomponent assemblies (e.g., crystalline structures) using oligonucleotide dendrimers and spherical nucleic acids (SNAs). The disclosure also provides methods of forming the multicomponent assemblies.

公开(公告)号：US20240309367A1

公开(公告)日：2024-09-19

申请号：US18271782

申请日：2022-01-11

Applicant: NORTHWESTERN UNIVERSITY

Inventor： Chad A. Mirkin ,  Andrew Joseph Sinegra

IPC: C12N15/113 ,  A61K9/51 ,  A61K31/713 ,  A61K47/28 ,  A61K47/54

CPC classification number: C12N15/113 ,  A61K9/513 ,  A61K31/713 ,  A61K47/28 ,  A61K47/549 ,  C12N2310/11 ,  C12N2310/122

Abstract: To treat disease, DNA and RNA therapeutics need to be delivered to target tissues and provide lasting benefit without side effects. Lipid nanoparticle spherical nucleic acids address this unmet need by using DNA and RNA sequences for nanoparticle targeting and tissue specificity. The lipid SNA structure has markedly different biodistribution properties than both lipid particles (loaded with nucleic acid) or even conventional SNAs (liposome and gold core).

公开(公告)号：US20240170061A1

公开(公告)日：2024-05-23

申请号：US18517238

申请日：2023-11-22

Applicant: NORTHWESTERN UNIVERSITY

Inventor： Chad A. Mirkin ,  Minliang Lai ,  Donghoon Shin

IPC: G11C13/04 ,  G03F7/00

CPC classification number: G11C13/04 ,  G03F7/0005

Abstract: Hybrid organic-inorganic metal perovskites are utilized to generate optical switches that can be laser written in an ultra-fast and low-energy process.

公开(公告)号：US20240165263A1

公开(公告)日：2024-05-23

申请号：US18283699

申请日：2022-03-30

Applicant: NORTHWESTERN UNIVERSITY

Inventor： Chad A. Mirkin ,  Michelle Hope Teplensky ,  Michael Evangelopoulos ,  Shuya Wang

IPC: A61K47/69 ,  A61K39/00 ,  A61K39/385 ,  A61K47/54 ,  A61K47/55 ,  A61P37/04

CPC classification number: A61K47/6925 ,  A61K39/001114 ,  A61K39/385 ,  A61K47/549 ,  A61K47/55 ,  A61K47/554 ,  A61K47/6911 ,  A61K47/6937 ,  A61P37/04 ,  A61K2039/55561 ,  A61K2039/575 ,  A61K2039/70

Abstract: The disclosure is generally related to spherical nucleic acids (SNAs), nanostructures with a core surrounded by a radial presentation of oligonucleotides, that can target multiple classes of immune cells. Methods of making and using the nanoparticles are also provided herein. In some aspects, the disclosure provides a spherical nucleic acid (SNA) comprising: (a) a nanoparticle core; (b) a shell of oligonucleotides attached to the external surface of the nanoparticle core, the shell of oligonucleotides comprising one or more immunostimulatory oligonucleotides; and (c) a first antigen that is a major histocompatibility complex type I (MHC-I) antigen, and a second antigen that is a major histocompatibility complex type II (MHC-II) antigen.

公开(公告)号：US11896943B2

公开(公告)日：2024-02-13

申请号：US16882002

申请日：2020-05-22

Applicant: NORTHWESTERN UNIVERSITY

Inventor： Chad A. Mirkin ,  Seungkyu Lee ,  Cindy Yizhe Zheng ,  Katherine E. Bujold

IPC: C07H1/00 ,  B01J13/00 ,  B01J13/18 ,  C30B29/58

CPC classification number: B01J13/0043 ,  B01J13/18 ,  C07H1/00 ,  C30B29/58

Abstract: Methods of stabilizing DNA-engineered crystals can include cross-linking the hybridized oligonucleotides. Stabilized crystals can have improved chemical and thermal stability.

公开(公告)号：US20240016737A1

公开(公告)日：2024-01-18

申请号：US18456371

申请日：2023-08-25

Applicant: Northwestern University

Inventor： C. Shad Thaxton ,  Chad A. Mirkin ,  Kaylin McMahon ,  Sushant Tripathy ,  Raja Kannan Mutharasan ,  David M. Leander ,  Andrea J. Luthi

IPC: A61K48/00 ,  A61K47/69 ,  A61K47/24 ,  A61K47/64

CPC classification number: A61K48/0033 ,  A61K47/6925 ,  A61K47/24 ,  A61K47/64

Abstract: Articles, compositions, kits, and methods relating to nanostructures, including synthetic nanostructures, are provided. Certain embodiments described herein include structures having a core-shell type arrangement; for instance, a nanostructure core may be surrounded by a shell including a material, such as a lipid bilayer, and may include other components such as oligonucleotides. In some embodiments, the structures, when introduced into a subject, can be used to deliver nucleic acids and/or can regulate gene expression. Accordingly, the structures described herein may be used to diagnose, prevent, treat or manage certain diseases or bodily conditions. In some cases, the structures are both a therapeutic agent and a diagnostic agent.

公开(公告)号：US20230313412A1

公开(公告)日：2023-10-05

申请号：US18024317

申请日：2021-09-08

Applicant: NORTHWESTERN UNIVERSITY

Inventor： Chad A. Mirkin ,  Yuanwei Li ,  Haixin Lin ,  Wenjie Zhou

IPC: C30B29/60 ,  C30B29/52 ,  C30B29/02

CPC classification number: C30B29/60 ,  C30B29/52 ,  C30B29/02 ,  B82Y40/00

Abstract: A method of site-selective growth of a nanocrystal from an anisotropic seed can include immersing an anisotropic seed functionalized with a ligand in a growth solution having a nanocrystal precursor, a complexing agent, and a reducing agent to form a growth solution, wherein an amount of the reducing agent and/or any amount of the complexing agent is selected to define a supersaturation of the growth solution that is sufficient for overcoming an energy barrier of one or more selected regions of the functionalized seed to selectively growth the nanocrystal at the one or more selected regions.

公开(公告)号：US11673197B2

公开(公告)日：2023-06-13

申请号：US17263832

申请日：2019-07-31

Applicant: NORTHWESTERN UNIVERSITY

Inventor： Chad A. Mirkin ,  Liliang Huang ,  Haixin Lin

IPC: B22F9/18 ,  C25B11/089 ,  C25B1/23 ,  C25B1/01 ,  B22F9/30 ,  B22F1/07 ,  B22F1/054 ,  B01J23/56 ,  B82Y30/00 ,  B82Y40/00

CPC classification number: B22F9/18 ,  B01J23/56 ,  B22F1/054 ,  B22F1/07 ,  B22F9/30 ,  C25B1/01 ,  C25B1/23 ,  C25B11/089 ,  B22F1/0553 ,  B22F2301/25 ,  B82Y30/00 ,  B82Y40/00

Abstract: Provided herein are methods of preparing tetrahexahedra nanoparticles and methods of using the tetrahexahedra nanoparticles as an oxidative catalyst.

公开(公告)号：US11534831B2

公开(公告)日：2022-12-27

申请号：US16913461

申请日：2020-06-26

Applicant: NORTHWESTERN UNIVERSITY

Inventor： Chad A. Mirkin ,  Liban Jibril ,  Pengcheng Chen

IPC: B22F9/30 ,  B01J19/00 ,  C21D1/607 ,  B82Y40/00 ,  B22F1/054

Abstract: Disclosed herein are methods for forming one or more nanoparticles. The methods include depositing a solution comprising a block copolymer and a metal salt into one or more square pyramidal nanoholes formed in a substrate, and annealing the substrate to provide a single nanoparticle in each of the one or more square pyramidal nanoholes.

公开(公告)号：US20220288181A1

公开(公告)日：2022-09-15

申请号：US17684269

申请日：2022-03-01

Applicant: NORTHWESTERN UNIVERSITY

Inventor： Chad A. Mirkin ,  Michelle Hope Teplensky ,  Max Everett Distler ,  Caroline Danielle Kusmierz ,  Cassandra Elizabeth Callmann

IPC: A61K39/00 ,  A61P35/00 ,  A61K39/39 ,  C12N15/113

Abstract: Spherical Nucleic Acids (SNAs) are chemically well-defined nanoscale architectures comprised of nucleic acids densely arranged around a spherical nanoparticle core in a highly oriented fashion. SNAs are highly modular structures produced by chemical synthesis and programmed assembly, allowing for their rapid modification to incorporate novel viral antigens. The present disclosure provides a SNA comprising (a) a nanoparticle core; (b) a shell of oligonucleotides attached to the external surface of the nanoparticle core, the shell of oligonucleotides comprising one or more immunostimulatory oligonucleotides; and (c) a viral antigen encapsulated in the nanoparticle core.