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93 条记录 (耗时 0.024 秒)

    Suture lock device
    2.
    发明授权
    Suture lock device 有权

    公开(公告)号：US11439384B2

    公开(公告)日：2022-09-13

    申请号：US16394192

    申请日：2019-04-25

    申请人： Muffin Incorporated

    发明人： Shaun Davis Gittard ,  John C. Sigmon, Jr. ,  Gregory James Hardy ,  Michelle Martinez ,  Vihar C. Surti ,  Jeremy T. Newkirk ,  William J. Havel ,  Neal E. Fearnot

    IPC分类号： A61B17/04 ,  A61B17/00

    摘要： Among other things, there are shown embodiments of locking mechanisms for holding sutures in tension. Such devices may be used with implants that use or require sutures, and are easily locked remotely. In particular embodiments, a lock includes a housing member, a pin member at least partially within the housing member, and a spring biasing the pin member into the housing member. The pin member includes a gripping portion, and has a retracted condition and a locked condition. When retracted, a suture can move through the housing member and around the gripping portion of the pin member. When locked, the gripping portion of the pin member engages the suture and presses it against the interior of the housing member.

    Over-the-wire ultrasound system with torque-cable driven rotary transducer
    4.
    发明授权
    Over-the-wire ultrasound system with torque-cable driven rotary transducer 有权

    公开(公告)号：US11317892B2

    公开(公告)日：2022-05-03

    申请号：US15221729

    申请日：2016-07-28

    申请人： Muffin Incorporated

    发明人： William J. Havel ,  Neal E. Fearnot ,  Sarah Robbins ,  Yun Zhou ,  Peter S. McKinnis ,  Marc C. Buhrmester

    IPC分类号： A61B8/00 ,  A61B8/12

    摘要： Disclosed are embodiments of devices and methods for imaging the inside of a body part, such as a blood vessel. In particular embodiments, a catheter has a chamber within which is a transducer. A wire guide channel extends throughout the length of the catheter. The transducer is rotatable about the wire guide channel and the transducer is driven by a cable or other device that is connected to a motor which is located outside the catheter. In one form, a torque cable connects the transducer to the motor. In other embodiments, a pusher piece having a plurality of lumens is positioned in the catheter. Each of the lumens is sized to receive a cable, wire, and/or flushing fluid. The lumens maintain the orientation and separation of the cables, wires, and/or to flushing fluid.

    Substantially acoustically transparent and conductive window
    6.
    发明授权
    Substantially acoustically transparent and conductive window 有权

    公开(公告)号：US10653391B2

    公开(公告)日：2020-05-19

    申请号：US14683235

    申请日：2015-04-10

    申请人： Muffin Incorporated

    发明人： Neal E. Fearnot ,  Peter S. McKinnis ,  Sarah Robbins ,  Yun Zhou

    IPC分类号： A61B8/12 ,  A61B8/00 ,  G01S15/89 ,  G01S7/52 ,  G10K11/35 ,  G10K11/00 ,  A61B90/00

    摘要： Among other things, there is disclosed structure and methods for registering images obtained through internal (e.g. intravascular) ultrasound devices. Embodiments of a device with a rotating ultrasound beam is provided, with a wall of the device being anisotropic in ultrasound passage. As examples, a cable opaque to ultrasound is attached along the wall of the device, so that the ultrasound beam at the location of the cable is blocked, reflected or scattered. As another example, a thin film of metallic material is placed on or in the wall to allow a portion of the beam to be blocked or attenuated. The imaging system recognizes the changes to the signals made by the anisotropic wall, and registers successive images according to those changes.

    Weeping balloon catheter with ultrasound element
    7.
    发明授权
    Weeping balloon catheter with ultrasound element 有权

    公开(公告)号：US10328290B2

    公开(公告)日：2019-06-25

    申请号：US13956407

    申请日：2013-08-01

    申请人： Muffin Incorporated

    发明人： Yun Zhou ,  Peter S. McKinnis ,  Sarah Robbins ,  Neal E. Fearnot

    IPC分类号： A61B17/22 ,  A61N7/00 ,  A61N7/02 ,  A61M25/10 ,  A61M37/00 ,  A61B18/00

    摘要： Systems and methods for treating a blood clot positioned within a blood vessel are disclosed. In one embodiment, a balloon member is positioned on a distal end region of a catheter and an ultrasound emitting element is positioned within the balloon member and arranged for actively emitting ultrasound. In some exemplary embodiments, the disclosure provides a multi-wall balloon member and a multi-lumen catheter with at least one and/or all cavities of the balloon member arranged for heat transfer with the ultrasound emitting element. The disclosure also provides catheter arrangements with an ultrasound emitting element arranged to heat tissue adjacent to the balloon member. Additionally, in some embodiments, at least one and/or all walls of the balloon member have apertures arranged to release a therapeutic agent such as a thrombolytic drug.

    Peripheral sealing venous check-valve
    8.
    发明授权
    Peripheral sealing venous check-valve 有权

    公开(公告)号：US10098739B2

    公开(公告)日：2018-10-16

    申请号：US14821067

    申请日：2015-08-07

    申请人： Muffin Incorporated

    发明人： Peter S. McKinnis ,  Neal E. Fearnot

    IPC分类号： A61F2/24 ,  A61F2/01

    摘要： Among other things, there are disclosed embodiments of a valve implant that in particular examples are implantable within a blood vessel, which include a first set of elongate members, a second set of elongate members, and a hood affixed to the first set of elongate members. The first set of elongate members is resiliently deformable, and their distal ends are flared radially outward. The distal ends of the second set of elongate members are distal to the ends of the first set of elongate members. The hood is affixed to the first set of elongate members, and seals against the interior wall of the blood vessel in an expanded configuration. When blood flows from the proximal to the distal side of the valve implant, it presses on the hood, compressing the first set of elongate members, breaking the seal.

    PRODUCTS COMPRISING AN EXTRACELLULAR MATRIX TISSUE MATERIAL AND OSTEOGENIC PROTEIN
    10.
    发明申请
    PRODUCTS COMPRISING AN EXTRACELLULAR MATRIX TISSUE MATERIAL AND OSTEOGENIC PROTEIN 有权
    包含细胞基质组织材料和蛋白质蛋白质的产品

    公开(公告)号：US20160263282A1

    公开(公告)日：2016-09-15

    申请号：US15058329

    申请日：2016-03-02

    申请人： Muffin Incorporated

    发明人： Shelly L. Wallace ,  Amanda F. Taylor ,  Steven Charlebois ,  Christine M. Steinhart ,  Neal E. Fearnot

    IPC分类号： A61L27/36 ,  A61L27/12 ,  A61L27/54

    CPC分类号： A61L27/3633 ,  A61L27/12 ,  A61L27/54 ,  A61L2300/414 ,  A61L2400/06 ,  A61L2430/02

    摘要： Osteogenic compositions include a decellularized extracellular matrix tissue and bone morphogenic protein, preferably BMP-2. The compositions make beneficial use of the BMP, which can be used at relatively low doses and can bind to native components (e.g., native sulfated glycosaminoglycans such as heparin and/or heparan sulfate) remaining in the decellularized extracellular matrix tissue. Methods for preparation and use of such compositions are also described. The compositions and related methods can be used in the treatment of diseased or damaged bone tissue.

    摘要翻译： 成骨组合物包括脱细胞的细胞外基质组织和骨形态发生蛋白，优选BMP-2。 所述组合物有利地使用BMP，其可以以相对低的剂量使用并且可以结合残留在脱细胞的细胞外基质组织中的天然组分（例如天然硫酸化糖胺聚糖如肝素和/或硫酸乙酰肝素）。 还描述了制备和使用这些组合物的方法。 组合物和相关方法可用于治疗患病或受损的骨组织。