公开(公告)号：US09604037B2

公开(公告)日：2017-03-28

申请号：US13910693

申请日：2013-06-05

申请人： Cook Medical Technologies LLC ,  Muffin Incorporated

发明人： Frank J. Fischer, Jr. ,  James R. Randolph ,  Neal E. Fearnot ,  Jimmy L. Taylor, Jr. ,  Gary Bradford Shirley

IPC分类号： A61M31/00 ,  A61M25/10 ,  A61M25/00 ,  A61M37/00

CPC分类号： A61M25/1011 ,  A61B34/20 ,  A61M25/0026 ,  A61M25/0041 ,  A61M25/0068 ,  A61M25/007 ,  A61M25/10 ,  A61M37/0092 ,  A61M2025/0003 ,  A61M2025/0004 ,  A61M2025/0042 ,  A61M2025/1015 ,  A61M2025/1052 ,  A61M2025/1061 ,  A61M2025/1093

摘要： Described in one aspect is a multi-pressure monitoring system for cell or other therapy includes a first catheter having a first lumen for accepting a treatment device, a second lumen for inflating a balloon, a pressure sensor for monitoring fluid pressure within the first lumen, and a flow restrictor such as a hemostasis valve for limiting the exchange of fluids into and out of the first lumen while treatment devices are present or exchanged in the first lumen. Also disclosed is a method of using the first catheter with a first pressure monitor coupled to the first pressure sensor along with a second catheter attached to a second pressure sensor coupled to a second pressure monitor. The second catheter is positioned within the first lumen of the first catheter during treatment operations and the first and second pressure monitors are used to verify proper pressures throughout the procedure. Described also are novel methods, systems, and catheters for delivering flowable therapeutic substances, such as viable cellular preparations, to patients.

公开(公告)号：US10532193B2

公开(公告)日：2020-01-14

申请号：US15453194

申请日：2017-03-08

申请人： Muffin Incorporated

发明人： Frank J. Fischer, Jr. ,  James R. Randolph ,  Neal E. Fearnot ,  Jimmy L. Taylor, Jr. ,  Gary B. Shirley

IPC分类号： A61M25/10 ,  A61M25/00 ,  A61M37/00 ,  A61B34/20

摘要： Described in one aspect is a multi-pressure monitoring system for cell or other therapy includes a first catheter having a first lumen for accepting a treatment device, a second lumen for inflating a balloon, a pressure sensor for monitoring fluid pressure within the first lumen, and a flow restrictor such as a hemostasis valve for limiting the exchange of fluids into and out of the first lumen while treatment devices are present or exchanged in the first lumen. Also disclosed is a method of using the first catheter with a first pressure monitor coupled to the first pressure sensor along with a second catheter attached to a second pressure sensor coupled to a second pressure monitor. The second catheter is positioned within the first lumen of the first catheter during treatment operations and the first and second pressure monitors are used to verify proper pressures throughout the procedure. Described also are novel methods, systems, and catheters for delivering flowable therapeutic substances, such as viable cellular preparations, to patients.

公开(公告)号：US20170173309A1

公开(公告)日：2017-06-22

申请号：US15453194

申请日：2017-03-08

申请人： Muffin Incorporated

发明人： Frank J. Fischer, JR. ,  James R. Randolph ,  Neal E. Fearnot ,  Jimmy L. Taylor, JR. ,  Gary B. Shirley

IPC分类号： A61M25/10 ,  A61B34/20 ,  A61M25/00

摘要： Described in one aspect is a multi-pressure monitoring system for cell or other therapy includes a first catheter having a first lumen for accepting a treatment device, a second lumen for inflating a balloon, a pressure sensor for monitoring fluid pressure within the first lumen, and a flow restrictor such as a hemostasis valve for limiting the exchange of fluids into and out of the first lumen while treatment devices are present or exchanged in the first lumen. Also disclosed is a method of using the first catheter with a first pressure monitor coupled to the first pressure sensor along with a second catheter attached to a second pressure sensor coupled to a second pressure monitor. The second catheter is positioned within the first lumen of the first catheter during treatment operations and the first and second pressure monitors are used to verify proper pressures throughout the procedure. Described also are novel methods, systems, and catheters for delivering flowable therapeutic substances, such as viable cellular preparations, to patients.

公开(公告)号：US20200147354A1

公开(公告)日：2020-05-14

申请号：US16742061

申请日：2020-01-14

申请人： Muffin Incorporated

发明人： Frank J. Fischer, JR. ,  James R. Randolph ,  Neal E. Fearnot ,  Jimmy L. Taylor, JR. ,  Gary B. Shirley

IPC分类号： A61M25/10 ,  A61B34/20 ,  A61M37/00 ,  A61M25/00

摘要： Described in one aspect is a multi-pressure monitoring system for cell or other therapy includes a first catheter having a first lumen for accepting a treatment device, a second lumen for inflating a balloon, a pressure sensor for monitoring fluid pressure within the first lumen, and a flow restrictor such as a hemostasis valve for limiting the exchange of fluids into and out of the first lumen while treatment devices are present or exchanged in the first lumen. Also disclosed is a method of using the first catheter with a first pressure monitor coupled to the first pressure sensor along with a second catheter attached to a second pressure sensor coupled to a second pressure monitor. The second catheter is positioned within the first lumen of the first catheter during treatment operations and the first and second pressure monitors are used to verify proper pressures throughout the procedure. Described also are novel methods, systems, and catheters for delivering flowable therapeutic substances, such as viable cellular preparations, to patients.

公开(公告)号：US20130338637A1

公开(公告)日：2013-12-19

申请号：US13910693

申请日：2013-06-05

申请人： Muffin Incorporated ,  Cook Medical Technologies LLC

发明人： Frank J. Fischer, JR. ,  James R. Randolph ,  Neal E. Fearnot ,  Jimmy L. Taylor, JR. ,  Gary Bradford Shirley

IPC分类号： A61M25/10

CPC分类号： A61M25/1011 ,  A61B34/20 ,  A61M25/0026 ,  A61M25/0041 ,  A61M25/0068 ,  A61M25/007 ,  A61M25/10 ,  A61M37/0092 ,  A61M2025/0003 ,  A61M2025/0004 ,  A61M2025/0042 ,  A61M2025/1015 ,  A61M2025/1052 ,  A61M2025/1061 ,  A61M2025/1093

摘要： Described in one aspect is a multi-pressure monitoring system for cell or other therapy includes a first catheter having a first lumen for accepting a treatment device, a second lumen for inflating a balloon, a pressure sensor for monitoring fluid pressure within the first lumen, and a flow restrictor such as a hemostasis valve for limiting the exchange of fluids into and out of the first lumen while treatment devices are present or exchanged in the first lumen. Also disclosed is a method of using the first catheter with a first pressure monitor coupled to the first pressure sensor along with a second catheter attached to a second pressure sensor coupled to a second pressure monitor. The second catheter is positioned within the first lumen of the first catheter during treatment operations and the first and second pressure monitors are used to verify proper pressures throughout the procedure. Described also are novel methods, systems, and catheters for delivering flowable therapeutic substances, such as viable cellular preparations, to patients.

摘要翻译： 一方面描述了一种用于细胞或其它疗法的多压力监测系统，包括具有用于接受治疗装置的第一腔的第一导管，用于充气气囊的第二腔，用于监测第一腔内的流体压力的压力传感器， 以及限流器，例如止血阀，用于在第一腔内存在或更换治疗装置的同时限制流体进入和离开第一腔的流体。 还公开了一种使用具有耦合到第一压力传感器的第一压力监测器的第一导管以及连接到耦合到第二压力监测器的第二压力传感器的第二导管的方法。 在治疗操作期间，第二导管定位在第一导管的第一腔内，并且在整个过程中使用第一和第二压力监测器来验证适当的压力。 还描述了用于向患者递送可流动治疗物质（例如活细胞制剂）的新颖方法，系统和导管。