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    Methods of harvesting and implanting follicular units using a coaxial tool
    2.
    发明授权
    Methods of harvesting and implanting follicular units using a coaxial tool 有权
    使用同轴工具收获和植入滤泡单位的方法

    公开(公告)号：US07621934B2

    公开(公告)日：2009-11-24

    申请号：US11421443

    申请日：2006-05-31

    申请人： Mohan Bodduluri ,  Paul K. Hsei

    发明人： Mohan Bodduluri ,  Paul K. Hsei

    IPC分类号： A61B17/34

    CPC分类号： A61B17/32053 ,  A61B10/0283 ,  A61B34/10 ,  A61B34/20 ,  A61B34/30 ,  A61B34/70 ,  A61B90/36 ,  A61B90/361 ,  A61B2010/0225 ,  A61B2017/00544 ,  A61B2017/00561 ,  A61B2017/00752 ,  A61B2034/2055 ,  A61B2090/065

    摘要： A method of transplanting a hair follicular units includes aligning a longitudinal axis of a harvesting cannula of a tool assembly with a longitudinal axis of a selected follicular unit, advancing the harvesting cannula relative to the body surface so that a tissue coring distal end of the harvesting cannula penetrates the body surface surrounding the selected follicular unit to a depth sufficient to substantially encapsulate the follicular unit, withdrawing the harvesting cannula distal end from the body surface with the follicular unit retained in an interior lumen of the harvesting cannula, advancing an implanting cannula of the tool assembly over the harvesting cannula relative to the body surface so that a tissue piercing distal end of the implanting cannula punctures the body surface and forms an implantation cavity therein, and displacing the follicular unit from the harvesting cannula lumen into the implantation cavity.

    摘要翻译： 移植毛囊单元的方法包括将工具组件的收获插管的纵向轴线与选定的滤泡单元的纵向轴线对准，使收获插管相对于身体表面前进，使得收割的组织取芯远端 插管穿过所选择的滤泡单元周围的身体表面，其深度足以基本上包封滤泡单元，将收集的套管远端从体表面撤回，滤泡单元保留在收获插管的内腔中，使植入插管 所述工具组件相对于所述身体表面在所述收集插管上方，使得所述植入插管的组织穿刺远端刺穿所述身体表面并在其中形成植入腔，并将所述滤泡单元从所述收获插管腔移位到所述植入腔中。

    Method for mixing laminar and turbulent flow streams
    5.
    发明授权
    Method for mixing laminar and turbulent flow streams 失效
    混合层流和湍流流的方法

    公开(公告)号：US5826977A

    公开(公告)日：1998-10-27

    申请号：US63966

    申请日：1998-04-21

    申请人： James E. Fowler ,  Paul K. Hsei

    发明人： James E. Fowler ,  Paul K. Hsei

    IPC分类号： B01F5/06

    CPC分类号： B01F5/0641

    摘要： A method of mixing substances under either laminar flow or turbulent flow conditions, or substances having a combination of laminar flow conditions. The method includes combining two or more initial fluidic substances into a combined fluid stream, dividing the combined fluid stream into two or more separate fluid streams, changing the shape of each of the two or more separate fluid streams in preparation for layering the two or more separate fluid streams together into a subsequent combined fluid stream such that each subsequent combined fluid stream has the same cross-sectional shape as the initial combined fluid stream and such that the cross-sectional area of the fluid stream is constant, and repeating the dividing, shaping and layering of the subsequent combined fluid stream at least one or more times.

    摘要翻译： 在层流或湍流条件下混合物质的方法，或具有层流条件组合的物质。 该方法包括将两种或多种初始流体物质组合成组合的流体流，将组合的流体流分成两个或更多个分离的流体流，改变两个或更多个分离的流体流中的每一个的形状，以准备分层两个或多个 单独的流体流在一起成为随后的组合流体流，使得每个随后的组合流体流具有与初始组合流体流相同的横截面形状，并且使得流体流的横截面积恒定，并且重复分开， 至少一次或多次后续组合流体流的成形和分层。

    Ion selective/enzymatic electrode medical analyzer device and method of use
    6.
    发明授权
    Ion selective/enzymatic electrode medical analyzer device and method of use 失效
    离子选择性/酶电极医用分析仪器及其使用方法

    公开(公告)号：US4935106A

    公开(公告)日：1990-06-19

    申请号：US798791

    申请日：1985-11-15

    申请人： Max D. Liston ,  Paul K. Hsei ,  David G. Dickinson ,  George M. Daffern ,  James G. Fetty

    发明人： Max D. Liston ,  Paul K. Hsei ,  David G. Dickinson ,  George M. Daffern ,  James G. Fetty

    IPC分类号： G01N27/26 ,  G01N27/28 ,  G01N33/487

    CPC分类号： G01N27/3271

    摘要： A modular multi-channel automated medical analyzer device is disclosed, characterized by use of an ion selective electrode and/or enzymatic electrode/wash cell system which permits rapid analysis of various substances of interest contained within undiluted body fluids such as whole blood, serum and/or plasma. The ion selective electrode and/or the enzymatic electrode are disposed upon a probe which automatically axially reciprocates downwardly in a simple manipulative motion between an open-ended reference wash cell and a sample cup bearing the body fluid specimen to be analyzed. The wash cell includes an inlet port and one or more outlet ports through which is circulated an aqueous solution bearing a known concentration of the substance to be measured to provide a reference calibration medium as well as a probe washing medium. The probe is lowered directly into the sample cup to physically contact the specimen to be measured and, after analysis, is lifted upwardly into the wash cell wherein any attendant portion of the specimen remaining on the probe is stripped off by suction and the aqueous solution flow through the wash cell is initiated to thoroughly wash the probe and establish a new calibration medium for subsequent specimen analysis. The wash cell/probe assembly is specifically designed to prevent any leakage or drooling of the aqueous solution from the wash cell into the sample cup throughout manipulation of the probe. Operation of each of the modules of the analyzer is facilitated through common processing and control electronics and test measurements are accomplished initially on a dual point calibration procedure and subsequently on a single point calibration procedure.

    摘要翻译： 公开了一种模块化多通道自动医学分析仪装置，其特征在于使用离子选择性电极和/或酶电极/洗涤细胞系统，其允许快速分析未稀释体液中所含的各种感兴趣物质，例如全血，血清和 /或等离子体。 离子选择电极和/或酶电极设置在探针上，该探针在开放式参考洗涤池和承载待分析体液样品的样品杯之间的简单操作运动中向下自动轴向往复运动。 洗涤池包括入口端口和一个或多个出口端口，循环具有已知浓度待测量物质的水溶液以提供参考校准介质以及探针洗涤介质。 将探针直接放入样品杯中以物理接触要测量的样品，并且在分析之后，将其向上提升到洗涤池中，其中留在探针上的样品的任何附加部分通过抽吸被剥离，并且水溶液流 通过洗涤池开始彻底清洗探针并建立新的校准介质，用于随后的样品分析。 洗涤池/探针组件被专门设计成防止在操纵探针时水溶液从洗涤池中渗入或流出到样品杯中。 通过共同的处理和控制电子装置便于分析器的每个模块的操作，并且测试测量最初在双点校准程序上完成，随后在单点校准程序上完成。

    Biopsy device
    7.
    发明授权
    Biopsy device 有权
    活检装置

    公开(公告)号：US07311673B2

    公开(公告)日：2007-12-25

    申请号：US10422381

    申请日：2003-04-24

    申请人： Richard L. Mueller, Jr. ,  Paul K. Hsei

    发明人： Richard L. Mueller, Jr. ,  Paul K. Hsei

    IPC分类号： A61B10/00

    CPC分类号： A61B10/0275 ,  A61B10/0041 ,  A61B2017/3488

    摘要： A biopsy device comprises a biopsy instrument, suitable for collecting at least one tissue sample from a body lumen, such as a mammary duct, and a cutter introducer sized for receiving the biopsy instrument and introducing the biopsy instrument into a mammary duct to retrieve a tissue sample therefrom.

    摘要翻译： 活组织检查装置包括活检装置，适于收集来自诸如乳腺管的体腔的至少一个组织样本，以及尺寸适于接收活检器械的切片导引器，并将活检器械引入乳腺管以取回组织 样品。

    Apparatus for mixing laminar and turbulent flow streams
    8.
    发明授权
    Apparatus for mixing laminar and turbulent flow streams 失效
    用于混合层流和湍流流的装置

    公开(公告)号：US5826981A

    公开(公告)日：1998-10-27

    申请号：US702967

    申请日：1996-08-26

    申请人： James E. Fowler ,  Paul K. Hsei

    发明人： James E. Fowler ,  Paul K. Hsei

    IPC分类号： B01F5/06

    CPC分类号： B01F5/0641

    摘要： A static mixer for mixing substances under either laminar flow or turbulent flow conditions, or for mixing substances having a combination of laminar and turbulent flow conditions. The static mixer includes a first conduit operatively connected to a series of two or more mixing segments. The mixing segments include one or more splitting components for dividing the fluid stream into two or more flow streams, two or more flow branches wherein each of the flow branches receives one of the flow streams and wherein each of the flow branches operatively changes the cross-sectional shapes of their respective flow streams in preparation for layering and stacking the flow streams to each other, and a second conduit for receiving and stacking the two or more flow streams creating a layered unified fluid stream.

    摘要翻译： 用于在层流或湍流条件下混合物质的静态混合器，或用于混合具有层流和湍流条件组合的物质。 静态混合器包括可操作地连接到一系列两个或更多个混合段的第一导管。 混合段包括用于将流体流分成两个或更多个流动流的两个或更多个流动分支的一个或多个分离组分，其中每个流动分支接收流动流中的一个，并且其中每个流动分支可操作地改变横截面， 其各自流动流的横截面形状用于将流动流彼此分层和堆叠，以及用于接收和堆叠两个或更多个流动流的第二导管，其形成分层的统一流体流。

    Enzymatic electrode and electrode module and method of use
    9.
    发明授权
    Enzymatic electrode and electrode module and method of use 失效
    酶电极和电极模块及使用方法

    公开(公告)号：US4891104A

    公开(公告)日：1990-01-02

    申请号：US42266

    申请日：1987-04-24

    申请人： Max D. Liston ,  Paul K. Hsei ,  Christopher C. Feistel

    发明人： Max D. Liston ,  Paul K. Hsei ,  Christopher C. Feistel

    IPC分类号： G01N27/28 ,  C12Q1/00 ,  G01N27/327 ,  G01N27/416 ,  G01N33/487

    CPC分类号： C12Q1/001

    摘要： An improved enzymatic electrode and electrode module specifically adapted for use in a medical analyzer device is disclosed which permits rapid analysis of substances of interest contained within undiluted body fluids such as whole blood, serum and/or plasma. The enzymatic electrode is in fluid communication with an axially reciprocating probe which selectively transports either a quantity of a buffer aqueous solution or a calibrant aqueous solution presented at a wash cell or a body fluid specimen disposed within a sample cup to an active enzyme bearing membrane positioned adjacent the enzymatic electrode. The membrane comprises a composite membrane structure having a protective membrane layer adapted to prevent the passage of blood cells and other particulate or cellular substances therethrough as well as adjust the diffusion rate of the substance of interest desired to be measured into the membrane, an active enzyme layer adapted to convert the desired substance of interest to be measured into a detectable substance and a limiting membrane formed to prevent the passage of interfering low molecular weight substance therethrough. The membrane/reagent chemistry kinetics of the enzymatic electrode are specifically defined to enable a novel pseudo-rate/created peak measurement technique to be utilized which reduces measurement inaccuracies as well as signal data processing requirements. The membrane/electrode support structure and membrane/electrode solution flow path are specifically formed to permit rapid replacement of the composite membrane and aqueous solutions by non-professional personnel.

    摘要翻译： 公开了一种特别适用于医疗分析装置的改进的酶电极和电极模块，其允许快速分析未稀释的体液如全血，血清和/或血浆中所含的感兴趣物质。 酶电极与轴向往复式探针流体连通，该探针选择性地将一定量的缓冲水溶液或呈现在洗涤池的校准液水溶液或设置在样品杯内的体液样品输送到位于 邻近酶电极。 膜包括具有保护膜层的复合膜结构，其适于防止血细胞和其它颗粒或细胞物质通过其中，并且调节所需要测量的物质的扩散速率到膜中，活性酶 层，其适于将要测量的所需物质转化为可检测物质和形成以防止干扰低分子量物质通过的限制膜。 酶电极的膜/试剂化学动力学具体定义为使得能够利用新的伪速率/创建的峰值测量技术，其减少测量不准确度以及信号数据处理要求。 膜/电极支撑结构和膜/电极溶液流动路径是特别形成的，以允许非专业人员快速更换复合膜和水溶液。