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    COMPOUNDS USEFUL AS ANTIVIRAL AGENTS, COMPOSITIONS, AND METHODS OF USE
    2.
    发明申请
    COMPOUNDS USEFUL AS ANTIVIRAL AGENTS, COMPOSITIONS, AND METHODS OF USE 有权
    化合物作为抗病毒剂，组合物和使用方法有用

    公开(公告)号：US20130090339A1

    公开(公告)日：2013-04-11

    申请号：US13703383

    申请日：2011-06-17

    申请人： Guoxin Wang ,  Ming Luo ,  Zhen Yang

    发明人： Guoxin Wang ,  Ming Luo ,  Zhen Yang

    IPC分类号： C07D417/14 ,  C07D417/06

    CPC分类号： C07D417/14 ,  C07D417/06

    摘要： Novel 3-N-cycloalkyl-5-substituted-2-thioxothiazolidin-4-one derivatives that are effective for use in treating viral infections are described. Also described are pharmaceutical compositions comprising the 3-N-cycloalkyl-5-substituted-2-thioxothiazolidin-4-one derivatives and methods for using the compounds or compositions.

    摘要翻译： 描述了有效用于治疗病毒感染的新的3-N-环烷基-5-取代-2-硫代噻唑烷-4-酮衍生物。 还描述了包含3-N-环烷基-5-取代-2-硫代噻唑烷-4-酮衍生物的药物组合物和使用该化合物或组合物的方法。

    Treating and preventing viral infections
    3.
    发明授权
    Treating and preventing viral infections 失效
    治疗和预防病毒感染

    公开(公告)号：US08466177B2

    公开(公告)日：2013-06-18

    申请号：US12682341

    申请日：2008-10-31

    申请人： Ming Luo ,  Zhen Yang

    发明人： Ming Luo ,  Zhen Yang

    IPC分类号： A61K31/4439 ,  A61K31/426 ,  A61K31/427 ,  C07D277/36 ,  C07D277/34 ,  C07D417/06

    CPC分类号： C07D417/06 ,  C07D277/36 ,  C07D413/14

    摘要： Compounds that are useful in treating or preventing viral infections, such as influenza, are described herein. Further described are compositions made from these compounds and methods for using the compounds and their compositions in treating or preventing viral infections.

    摘要翻译： 可用于治疗或预防病毒感染（例如流感）的化合物在本文中描述。 进一步描述的是由这些化合物制成的组合物和使用该化合物及其组合物治疗或预防病毒感染的方法。

    Electric reciprocating motion device with spring motor
    7.
    发明授权
    Electric reciprocating motion device with spring motor 有权
    带弹簧电机的电动往复运动装置

    公开(公告)号：US07960877B2

    公开(公告)日：2011-06-14

    申请号：US12454277

    申请日：2009-05-14

    申请人： Ming Luo

    发明人： Ming Luo

    IPC分类号： H02K33/00 ,  H02K41/02

    CPC分类号： H02K33/16 ,  A61C17/3418 ,  H02K33/04

    摘要： An electric reciprocating motion device includes a motor having a rotary shaft for outputting a reciprocating rotational power and a motion head coupling with the rotary shaft and being driven to move in a reciprocating motion along an axis of the rotary shaft and in a predetermined swing angle range. The motor is a spring motor including a motor unit and a torsion spring having two ends affixing at a motor housing and to the rotary shaft respectively. After the rotary shaft outputs a mechanical torque at one rotational direction, the torsion spring applies a spring force against the rotary shaft to drive the rotary shaft to rotate backward for generating the reciprocating rotational power. Using the spring motor in the electric reciprocating motion device, the device achieves the goals of simple mechanical structure, small volume, easy to install, and low in cost.

    摘要翻译： 电动往复运动装置包括具有用于输出往复旋转动力的旋转轴和与该旋转轴联动的运动头的马达，该马达被驱动沿着旋转轴的轴线往复运动并以预定的摆动角度范围 。 电动机是包括马达单元和扭簧的弹簧马达，所述扭力弹簧具有分别固定在马达壳体和旋转轴上的两端。 在旋转轴在一个旋转方向上输出机械扭矩之后，扭转弹簧向旋转轴施加弹簧力以驱动旋转轴向后旋转以产生往复旋转动力。 在电动往复运动装置中使用弹簧电机，实现了机械结构简单，体积小，安装方便，成本低的目的。

    Chromogenic substrates of sialidase and methods of making and using the same
    8.
    发明授权
    Chromogenic substrates of sialidase and methods of making and using the same 有权
    唾液酸酶的显色底物及其制备和使用方法

    公开(公告)号：US06844346B2

    公开(公告)日：2005-01-18

    申请号：US10328790

    申请日：2002-12-24

    申请人： Stephen C. Johnson ,  Ashraf Saeed ,  Ming Luo

    发明人： Stephen C. Johnson ,  Ashraf Saeed ,  Ming Luo

    IPC分类号： C07H7/027 ,  C07H15/203 ,  C07H15/24 ,  C07H17/02 ,  C07H17/075 ,  C07H15/04 ,  C07H17/04

    CPC分类号： C07H15/203 ,  C07H7/027 ,  C07H15/24 ,  C07H17/02 ,  C07H17/075

    摘要： The subject invention discloses materials and methods for the design, synthesis, and biochemical evaluation of chromogenic substrate compounds for sialidases of bacterial, viral, protozoa, and vertebrate (including humans) origin. These compounds are based upon N-acetylneuraminic acid glycosides. In particular, this invention provides a novel class of these compounds as chromogenic substrates of these sialidases which yield chromogenic products after reactions catalyzed by sialidase take place. Also provided are methods of making these substrate compounds, methods of diagnosis and prognosis of sialidase related diseases using these substrate compounds.

    摘要翻译： 本发明公开了用于细菌，病毒，原生动物和脊椎动物（包括人）起源的唾液酸酶的显色底物化合物的设计，合成和生物化学评估的材料和方法。 这些化合物基于N-乙酰神经氨酸糖苷。 特别地，本发明提供了一类新颖的这些化合物作为这些唾液酸酶的显色底物，其在由唾液酸酶催化的反应后产生显色产物。 还提供了使用这些底物化合物制备这些底物化合物的方法，唾液酸酶相关疾病的诊断和预后的方法。

    Methods of inhibiting bacterial sialidase
    9.
    发明授权
    Methods of inhibiting bacterial sialidase 失效
    抑制细菌唾液酸酶的方法

    公开(公告)号：US5985859A

    公开(公告)日：1999-11-16

    申请号：US485380

    申请日：1995-06-07

    申请人： Ming Luo

    发明人： Ming Luo

    IPC分类号： A61K31/195 ,  A61K31/185 ,  A61K31/192 ,  A61K31/196 ,  A61K31/215 ,  A61K31/222 ,  A61P31/12 ,  A61P43/00 ,  A01N57/14 ,  A01N37/10 ,  A01N37/44 ,  A61K31/66

    CPC分类号： A61K31/662 ,  A61K31/185 ,  A61K31/192 ,  A61K31/196 ,  A61K31/222 ,  Y10S514/888

    摘要： A method of inhibiting bacterial sialidase comprising administering to a subject an inhibiting effective amount of a compound of formula I: ##STR1## wherein A is CO.sub.2 H, PO.sub.2 H, or SO.sub.2 H; B is N; R.sub.1 and R.sub.2 are H; R.sub.3 and R.sub.4 are, independently, H, OH, NO.sub.2, guanidino, or alkyl or alkenyl of from 1 to 3 carbons where the alkyl or alkenyl is unsubstituted or is substituted, independently, with one or more of OH, NH2, or halide; R.sub.5 is H; and R.sub.6 is COCH.sub.3, or COCI.sub.3 ; or an analog, pharmaceutically acceptable salt, derivative, or mixture thereof. A method of preventing a bacterial or trypanosomal infection using the compounds of formula I. A method of treating a bacterial or trypanosomal infection using the compounds of formula I. A pharmaceutical composition comprising a pharmaceutically acceptable carrier admixed with an inhibiting effective amount of a compound of formula I. A method of making a pharmaceutical composition, comprising admixing a pharmaceutically acceptable carrier with an inhibiting effective amount of a compound of formula I.

    摘要翻译： 一种抑制细菌唾液酸酶的方法，包括向受试者施用抑制有效量的式I化合物：其中A是CO 2 H，PO 2 H或SO 2 H; B是N; R1和R2是H; R 3和R 4独立地为1至3个碳的H，OH，NO 2，胍基或烷基或烯基，其中烷基或烯基是未取代的或被OH，NH 2或卤化物中的一种或多种独立地取代; R5是H; 并且R 6是COCH 3或COCl 3; 或其类似物，药学上可接受的盐，衍生物或其混合物。 一种使用式I化合物预防细菌或锥虫感染的方法。一种使用式I化合物治疗细菌或锥虫感染的方法。一种药物组合物，其包含药学上可接受的载体，其与抑制有效量的化合物 式I.制备药物组合物的方法，包括将药学上可接受的载体与抑制有效量的式I化合物混合。