Chromogenic substrates of sialidase and methods of making and using the same
    6.
    发明授权
    Chromogenic substrates of sialidase and methods of making and using the same 有权
    唾液酸酶的显色底物及其制备和使用方法

    公开(公告)号:US06512100B1

    公开(公告)日:2003-01-28

    申请号:US09651622

    申请日:2000-08-30

    CPC classification number: C07H15/203 C07H7/027 C07H15/24 C07H17/02 C07H17/075

    Abstract: The subject invention discloses materials and methods for the design, synthesis, and biochemical evaluation of chromogenic substrate compounds for sialidases of bacterial, viral, protozoa, and vertebrate (including humans) origin. In particular, this invention provides a novel class of effective compounds as chromogenic substrates of these sialidases which yield chromogenic products after reactions catalyzed by sialidase take place. Also provided are methods of making these substrate compounds, methods of diagnosis and prognosis of sialidase related diseases using these substrate compounds.

    Abstract translation: 本发明公开了用于细菌,病毒,原生动物和脊椎动物(包括人)起源的唾液酸酶的显色底物化合物的设计,合成和生物化学评估的材料和方法。 特别地,本发明提供了一种新型的有效化合物作为这些唾液酸酶的显色底物,其在由唾液酸酶催化的反应发生后产生显色产物。 还提供了使用这些底物化合物制备这些底物化合物的方法,唾液酸酶相关疾病的诊断和预后的方法。

    Triazole ppar modulators
    9.
    发明申请
    Triazole ppar modulators 失效
    三唑ppar调节剂

    公开(公告)号:US20070112045A1

    公开(公告)日:2007-05-17

    申请号:US10580202

    申请日:2004-12-21

    Abstract: The present invention is directed to compounds represented by the following structural formula, Formula (I): wherein: (a) X is selected from the group consisting of a single bond, O, S, S(O)2 and N; (b) U is an aliphatic linker; (c) Y is selected from the group consisting of O, C, S, NH and a single bond; (d) W is N, O or S; (e) E is C(R3)(R4)A or A and wherein; (f) A is selected from the group consisting of carboxyl, tetrazole, C1-C6 alkylnitrile, carboxamide, sulfonamide and acylsufonamide. The other substituents are defined in the claims; the compounds are modulators of peroxisome proleferator activated receptors (PPARs) and are useful for the treatment of diabetes and other metabolic disorders.

    Abstract translation: 本发明涉及由下列结构式(I)表示的化合物:其中:(a)X选自单键,O,S,S(O)2, SUB>和N; (b)U是脂族连接体; (c)Y选自O,C,S,NH和单键; (d)W是N,O或S; (e)E是C(R3)(R4)A或A,其中; (f)A选自羧基,四唑,C 1 -C 6烷基腈,甲酰胺,磺酰胺和酰基磺酰胺。 其它取代基在权利要求书中定义; 该化合物是过氧化物酶体促进剂激活受体(PPAR)的调节剂,可用于治疗糖尿病和其他代谢紊乱。

    Chromogenic substrates of sialidase and methods of making and using the same
    10.
    发明授权
    Chromogenic substrates of sialidase and methods of making and using the same 有权
    唾液酸酶的显色底物及其制备和使用方法

    公开(公告)号:US06844346B2

    公开(公告)日:2005-01-18

    申请号:US10328790

    申请日:2002-12-24

    CPC classification number: C07H15/203 C07H7/027 C07H15/24 C07H17/02 C07H17/075

    Abstract: The subject invention discloses materials and methods for the design, synthesis, and biochemical evaluation of chromogenic substrate compounds for sialidases of bacterial, viral, protozoa, and vertebrate (including humans) origin. These compounds are based upon N-acetylneuraminic acid glycosides. In particular, this invention provides a novel class of these compounds as chromogenic substrates of these sialidases which yield chromogenic products after reactions catalyzed by sialidase take place. Also provided are methods of making these substrate compounds, methods of diagnosis and prognosis of sialidase related diseases using these substrate compounds.

    Abstract translation: 本发明公开了用于细菌,病毒,原生动物和脊椎动物(包括人)起源的唾液酸酶的显色底物化合物的设计,合成和生物化学评估的材料和方法。 这些化合物基于N-乙酰神经氨酸糖苷。 特别地,本发明提供了一类新颖的这些化合物作为这些唾液酸酶的显色底物,其在由唾液酸酶催化的反应后产生显色产物。 还提供了使用这些底物化合物制备这些底物化合物的方法,唾液酸酶相关疾病的诊断和预后的方法。

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