Invention Grant
US06844346B2 Chromogenic substrates of sialidase and methods of making and using the same 有权
唾液酸酶的显色底物及其制备和使用方法

Chromogenic substrates of sialidase and methods of making and using the same
Abstract:
The subject invention discloses materials and methods for the design, synthesis, and biochemical evaluation of chromogenic substrate compounds for sialidases of bacterial, viral, protozoa, and vertebrate (including humans) origin. These compounds are based upon N-acetylneuraminic acid glycosides. In particular, this invention provides a novel class of these compounds as chromogenic substrates of these sialidases which yield chromogenic products after reactions catalyzed by sialidase take place. Also provided are methods of making these substrate compounds, methods of diagnosis and prognosis of sialidase related diseases using these substrate compounds.
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