Invention Grant
- Patent Title: Chromogenic substrates of sialidase and methods of making and using the same
- Patent Title (中): 唾液酸酶的显色底物及其制备和使用方法
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Application No.: US10328790Application Date: 2002-12-24
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Publication No.: US06844346B2Publication Date: 2005-01-18
- Inventor: Stephen C. Johnson , Ashraf Saeed , Ming Luo
- Applicant: Stephen C. Johnson , Ashraf Saeed , Ming Luo
- Applicant Address: US AL Birmingham US AL Birmingham
- Assignee: IBBEX, Inc.,Univ. of Alabama at Birmingham
- Current Assignee: IBBEX, Inc.,Univ. of Alabama at Birmingham
- Current Assignee Address: US AL Birmingham US AL Birmingham
- Agency: Saliwanchik, Lloyd & Saliwanchik
- Main IPC: C07H7/027
- IPC: C07H7/027 ; C07H15/203 ; C07H15/24 ; C07H17/02 ; C07H17/075 ; C07H15/04 ; C07H17/04
Abstract:
The subject invention discloses materials and methods for the design, synthesis, and biochemical evaluation of chromogenic substrate compounds for sialidases of bacterial, viral, protozoa, and vertebrate (including humans) origin. These compounds are based upon N-acetylneuraminic acid glycosides. In particular, this invention provides a novel class of these compounds as chromogenic substrates of these sialidases which yield chromogenic products after reactions catalyzed by sialidase take place. Also provided are methods of making these substrate compounds, methods of diagnosis and prognosis of sialidase related diseases using these substrate compounds.
Public/Granted literature
- US20030181691A1 Chromogenic substrates of sialidase and methods of making and using the same Public/Granted day:2003-09-25
Information query
