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公开(公告)号：US20180271939A1
公开(公告)日：2018-09-27
申请号：US15927007
申请日：2018-03-20
CPC分类号： A61K38/1767 , A61K48/0016 , A61K48/005 , A61K48/0075 , A61P35/00 , C12N15/85 , C12N15/88
摘要： A genetic method to kill cancer by suffocation is presented. The invention involves directly administering a bacterial plasmid in the form of an expression vector to cancer cells or tissue in a patient with cancerous growth. The plasmid is in the form of an expression vector with a nucleic acid encoding the silk protein gene.
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公开(公告)号：US5514581A
公开(公告)日：1996-05-07
申请号：US609716
申请日：1990-11-06
申请人： Franco A. Ferrari , Joseph Cappello
发明人： Franco A. Ferrari , Joseph Cappello
IPC分类号： A61L17/00 , A61L29/04 , C07K14/00 , C07K14/435 , C07K14/78 , C07K17/08 , C12N1/06 , C12N5/00 , C12N15/11 , C12N15/62 , C12N15/66 , C12N15/70 , C12N15/75 , G03C1/047 , C12N1/21 , C12N15/12
CPC分类号： A61L17/00 , A61L29/049 , C07K14/00 , C07K14/43586 , C07K14/78 , C07K17/08 , C12N1/06 , C12N15/11 , C12N15/62 , C12N15/66 , C12N15/70 , C12N15/75 , C12N5/0068 , C07K2319/00 , C07K2319/02 , C07K2319/33 , C07K2319/61 , C12N2533/30 , C12N2533/52 , G03C1/047
摘要： Novel polymers are provided which are produced by recombinant techniques. The polymers are characterized by having a small repeating sequence which provides for strands capable of associating, resulting in useful structural characteristics, where the strands are joined by turns or loops which are flexible and available for interaction with the environment. Specifically, repeating groups of naturally occurring proteins such as silk are modified by introduction of an amino-acid sequence at a site which provides for a turn between strands to provide for readily available oligopeptides capable of interacting with molecules in the environment.
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公开(公告)号：US5641648A
公开(公告)日：1997-06-24
申请号：US175155
申请日：1993-12-29
CPC分类号： C12N15/66 , C07K14/43586 , C12N15/62 , C07K2319/00 , C07K2319/02 , C07K2319/33 , C07K2319/61
摘要： Methods are provided for the production of large polypeptides containing repeating sequences of amino acids utilizing biochemical techniques, specifically DNA sequences coding for the expression of the large polypeptides. Systems utilizing exogenous transcriptional and translational regions to control the production of the large polypeptides are also provided.
摘要翻译： 提供了使用生化技术生产含有氨基酸重复序列的大多肽的方法，特别是编码大多肽表达的DNA序列。 还提供了利用外源转录和翻译区以控制大多肽的产生的系统。
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公开(公告)号：US5235041A
公开(公告)日：1993-08-10
申请号：US869212
申请日：1992-04-13
IPC分类号： C07K1/36 , C07K14/435 , C07K14/78
CPC分类号： C07K14/435 , C07K1/36 , C07K14/78
摘要： Recombinant structural and functional polymers are purified by lysing of the cellular host, separation of the solid materials, washing and extraction of contaminants using a detergent solution at elevated temperatures.
摘要翻译： 重组结构和功能性聚合物通过细胞宿主的裂解，固体物质的分离，在高温下使用洗涤剂溶液洗涤和提取污染物来纯化。
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5.发明授权Peptides comprising repetitive units of amino acids and DNA sequences encoding the same 失效包含氨基酸重复单元和编码氨基酸的DNA序列的肽
公开(公告)号：US6018030A
公开(公告)日：2000-01-25
申请号：US482085
申请日：1995-06-07
申请人： Franco A. Ferrari , Charles Richardson , James Chambers , Stuart Causey , Thomas J. Pollock , Joseph Cappello , John W. Crissman
发明人： Franco A. Ferrari , Charles Richardson , James Chambers , Stuart Causey , Thomas J. Pollock , Joseph Cappello , John W. Crissman
IPC分类号： C07K14/435 , C07K14/78 , C12N1/06 , C12N15/11 , C12N15/62 , C12N15/70 , C12N15/75 , A61K38/17 , C07H21/04 , C12N5/00
CPC分类号： C07K14/43586 , C07K14/78 , C12N1/06 , C12N15/11 , C12N15/62 , C12N15/66 , C12N15/70 , C12N15/75 , C07K2319/00 , C07K2319/02 , C07K2319/33 , C07K2319/61
摘要： Polypeptides comprising repetitive units of amino acids, as well as synthetic genes encoding the subject polypeptides are provided. The subject polypeptides are characterized by comprising repetitive units of amino acids, where the repetitive units are present in naturally occurring proteins, particularly naturally occurring structural proteins. The subject polypeptides find use in a variety of applications, such as structural components of prosthetic devices, synthetic fibers, and the like.
摘要翻译： 提供了包含氨基酸重复单元的多肽，以及编码本发明多肽的合成基因。 主题多肽的特征在于包含氨基酸的重复单元，其中重复单元存在于天然存在的蛋白质中，特别是天然存在的结构蛋白质中。 主题多肽可用于各种应用，例如假体装置的结构部件，合成纤维等。
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公开(公告)号：US5770697A
公开(公告)日：1998-06-23
申请号：US477509
申请日：1995-06-07
申请人： Franco A. Ferrari , Charles Richardson , James Chambers , Stuart Causey , Thomas J. Pollock , Joseph Cappello , John W. Crissman
发明人： Franco A. Ferrari , Charles Richardson , James Chambers , Stuart Causey , Thomas J. Pollock , Joseph Cappello , John W. Crissman
IPC分类号： C07K14/435 , C07K14/78 , C12N1/06 , C12N15/11 , C12N15/62 , C12N15/70 , C12N15/75 , A61K38/17 , A61K38/39 , C12P21/02
CPC分类号： C12N15/62 , C07K14/43586 , C07K14/78 , C12N1/06 , C12N15/11 , C12N15/70 , C12N15/75 , C07K2319/00 , C07K2319/02 , C07K2319/61
摘要： Novel polypeptides comprising repetitive units of amino acids, as well as synthetic genes encoding the subject polypeptides are provided. The subject polypeptides are characterized by comprising repetitive units of amino acids, where the repetitive units are present in naturally occurring proteins, particularly naturally occurring structural proteins. The subject polypeptides find use in a variety of applications, such as structural components of prosthetic devices, synthetic fibers, and the like.
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7.发明申请Novel peptides comprising repetitive units of amino acids and DNA sequences encoding the same 失效包含氨基酸重复单元和编码氨基酸的DNA序列的新型肽公开(公告)号：US20090093621A1
公开(公告)日：2009-04-09
申请号：US11415484
申请日：2006-04-27
申请人： Franco A. Ferrari , Joseph Cappello
发明人： Franco A. Ferrari , Joseph Cappello
CPC分类号： C07K14/43586 , C07K14/78 , C07K2319/00 , C07K2319/02 , C07K2319/33 , C07K2319/61 , C12N1/06 , C12N15/11 , C12N15/62 , C12N15/66 , C12N15/70 , C12N15/75
摘要： Novel polypeptides comprising repetitive units of amino acids, as well as synthetic genes encoding the subject polypeptides are provided. The subject polypeptides are characterized by comprising repetitive units of amino acids, where the repetitive units are present in naturally occurring proteins, particularly naturally occurring structural proteins. The subject polypeptides find use in a variety of applications, such as structural components of prosthetic devices, synthetic fibers, and the like.
摘要翻译： 提供了包含氨基酸重复单元的新型多肽，以及编码本发明多肽的合成基因。 主题多肽的特征在于包含氨基酸的重复单元，其中重复单元存在于天然存在的蛋白质中，特别是天然存在的结构蛋白质中。 主题多肽可用于各种应用，例如假体装置的结构部件，合成纤维等。
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公开(公告)号：US6140072A
公开(公告)日：2000-10-31
申请号：US475411
申请日：1995-06-07
申请人： Franco A. Ferrari , Joseph Cappello
发明人： Franco A. Ferrari , Joseph Cappello
IPC分类号： A61L17/00 , A61L29/04 , C07K14/00 , C07K14/435 , C07K14/78 , C07K17/08 , C12N1/06 , C12N5/00 , C12N15/11 , C12N15/62 , C12N15/66 , C12N15/70 , C12N15/75 , G03C1/047 , C07K13/00
CPC分类号： A61L17/00 , A61L29/049 , C07K14/00 , C07K14/43586 , C07K14/78 , C07K17/08 , C12N1/06 , C12N15/11 , C12N15/62 , C12N15/66 , C12N15/70 , C12N15/75 , C12N5/0068 , C07K2319/00 , C07K2319/02 , C07K2319/33 , C07K2319/61 , C12N2533/30 , C12N2533/52 , G03C1/047
摘要： Novel polymers are provided which are produced by recombinant techniques. The polymers are characterized by having a small repeating sequence which provides for strands capable of associating, resulting in useful structural characteristics, where the strands are joined by turns or loops which are flexible and available for interaction with the environment. Specifically, repeating groups of naturally occurring proteins such as silk are modified by introduction of an amino-acid sequence at a site which provides for a turn between strands to provide for readily available oligopeptides capable of interacting with molecules in the environment.
摘要翻译： 提供了通过重组技术产生的新型聚合物。 聚合物的特征在于具有小的重复序列，其提供能够缔合的链，产生有用的结构特征，其中链通过柔性并可用于与环境相互作用的匝或环连接。 具体地说，重复天然存在的蛋白质如丝绸的组是通过在提供链之间转向的位置处引入氨基酸序列来修饰的，以提供能够与环境中的分子相互作用的容易获得的寡肽。
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公开(公告)号：US5773249A
公开(公告)日：1998-06-30
申请号：US642255
申请日：1996-05-02
申请人： Joseph Cappello , Franco A. Ferrari
发明人： Joseph Cappello , Franco A. Ferrari
IPC分类号： C07K14/78 , C12N15/66 , C12P21/02 , C07K14/435 , C12N15/12
CPC分类号： C07K14/78 , C12N15/66 , C07K2319/00 , C07K2319/02 , C07K2319/33 , C07K2319/61
摘要： Collagen-like polymers having repetitive triads are produced having reduced proline content, where glycine is the initial amino acid and the subsequent amino acids are varied, while retaining at least a minimum percentage of prolines. The resulting polymers have collagen-like properties, but are capable of being produced in unicellular microorganisms at high molecular weights and in high efficiency. The polymers, while retaining collagen-like characteristics, include various novel sequences which impart new characteristics, finding wide use in photographic, medical, structural and fiber applications.
摘要翻译： 制备具有重复三联体的胶原样聚合物，其具有降低的脯氨酸含量，其中甘氨酸是初始氨基酸，随后的氨基酸变化，同时保持至少最小百分比的脯氨酸。 所得聚合物具有胶原样性质，但能够以高分子量和高效率在单细胞微生物中生产。 聚合物在保留胶原样特征的同时，包括赋予新特性的各种新型序列，在摄影，医疗，结构和纤维应用中得到广泛应用。
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公开(公告)号：US5496712A
公开(公告)日：1996-03-05
申请号：US972032
申请日：1992-11-05
申请人： Joseph Cappello , Franco A. Ferrari
发明人： Joseph Cappello , Franco A. Ferrari
CPC分类号： C07K14/78 , A61K38/00 , C07K2319/00 , C07K2319/02 , G03C1/047
摘要： Collagen-like polymers having repetitive triads are produced having reduced proline content, where glycine is the initial amino acid and the subsequent amino acids are varied, while retaining at least a minimum percentage of prolines. The resulting polymers have collagen-like properties, but are capable of being produced in unicellular microorganisms at high molecular weights and in high efficiency. The polymers while retaining collagen-like characteristics, include various novel sequences which impart new characteristics, finding wide use in photographic, medical, structural and fiber applications.
摘要翻译： 制备具有重复三联体的胶原样聚合物，其具有降低的脯氨酸含量，其中甘氨酸是初始氨基酸，随后的氨基酸变化，同时保持至少最小百分比的脯氨酸。 所得聚合物具有胶原样性质，但能够以高分子量和高效率在单细胞微生物中生产。 同时保留胶原样特征的聚合物包括赋予新特性的各种新型序列，在照相，医学，结构和纤维应用中广泛使用。
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