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公开(公告)号：US20170202467A1
公开(公告)日：2017-07-20
申请号：US15411936
申请日：2017-01-20
CPC分类号： A61B5/04001 , A61B5/0031 , A61B5/6877 , A61B5/7225 , A61B2560/0219 , A61B2562/12 , A61B2562/162 , A61N1/0556 , A61N1/36053 , A61N1/3606 , A61N1/37205 , A61N1/37229 , A61N1/37518 , A61N1/3756 , A61N1/3787
摘要： Methods and apparatuses (e.g., devices and systems) for vagus nerve stimulation, including (but not limited to) sub-diaphragmatic vagus nerve stimulation. In particular, the methods and apparatuses described herein may be used to stimulate the posterior sub-diaphragmatic vagus nerve to treat inflammation and/or inflammatory disorders. The implantable microstimulators described herein may be inductively charged and/or communicated with using the external charger. The implant may include a receiving antenna wrapped around the battery and/or the housing of the microstimulator/microregulator and/or may include a high magnetic permeability material in order to serve as a magnetic core for the antenna coil. Wearable inductive chargers/communication devices for inductively communicating with (including charging) an implanted microstimulator are described herein, which may include magnetically conductive material to enhance communication with an implant, including sub-diaphragmatic implants. Also described herein are inductive chargers/communication devices, including belts, and pads (e.g., mattresses) able to recharge an implanted neurostimulation device.
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公开(公告)号：US20170197076A1
公开(公告)日：2017-07-13
申请号：US15406619
申请日：2017-01-13
CPC分类号： A61N1/0556 , A61B5/04001 , A61B5/4047 , A61B5/4824 , A61B5/4839 , A61B5/4848 , A61B5/6877 , A61B2505/09 , A61B2562/168 , A61M5/14236 , A61M2005/1726 , A61M2205/3584 , A61M2230/08 , A61N1/3606 , A61N1/36071 , A61N1/37205
摘要： A nerve cuff for establishing a nerve block on a nerve can have a cuff body with a channel for receiving a nerve, a reservoir for holding a drug, and an elongate opening slit extending the length of the cuff body that can be opened to provide access to the channel and can be closed to enclose the cuff body around the nerve. The nerve cuff can also include an electrode for detecting and measuring electrical signals generated by the nerve. A controller can be used to control delivery of the drug based on the electrical signals generated by the nerve.
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公开(公告)号：US20170203103A1
公开(公告)日：2017-07-20
申请号：US15411933
申请日：2017-01-20
摘要： Methods and apparatuses for stimulation of the vagus nerve to treat inflammation including adjusting the stimulation based on one or more metric sensitive to patient response. The one or more metrics may include heart rate variability, level of T regulatory cells, particularly memory T regulatory cells, temperature, etc. Stimulation may be provided through an implantable microstimulator.
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公开(公告)号：US20160331952A1
公开(公告)日：2016-11-17
申请号：US15153639
申请日：2016-05-12
CPC分类号： A61N1/025 , A61N1/36053 , A61N1/36125 , A61N1/37205 , A61N1/37247 , A61N1/37252 , G06F1/12 , G16H40/40 , G16H40/63
摘要： An external programmer, such as an external clock synchronization tool, can be used to update or modify the stimulation protocol and/or parameters on an implanted electrical stimulator. In particular, described herein are external clock synchronization tools that can be used to calibrate a low-power clock of the implanted electrical stimulator. These tools may also be used to provide command overrides, including suspending or delaying neurostimulation, stopping neurostimulation, and/or on-demand neurostimulation.
摘要翻译： 诸如外部时钟同步工具的外部编程器可用于更新或修改植入的电刺激器上的刺激协议和/或参数。 特别地，这里描述的是外部时钟同步工具，其可用于校准植入的电刺激器的低功率时钟。 这些工具也可用于提供命令覆盖，包括暂停或延迟神经刺激，停止神经刺激和/或按需神经刺激。
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5.发明申请公开(公告)号：US20170209705A1
公开(公告)日：2017-07-27
申请号：US15415764
申请日：2017-01-25
申请人： Michael A. FALTYS , Jesse M. SIMON
发明人： Michael A. FALTYS , Jesse M. SIMON
CPC分类号： A61N1/3787 , A61N1/36053 , A61N1/3606 , A61N1/37205 , A61N1/3756
摘要： Leadless, implantable microstimulators for treating chronic inflammation. These devices can include a static magnetic field detector (e.g., non-Hall effect sensors/detectors, including those based on a Wiegand effect or generating pulses at a predetermined frequency range and using a detection circuit to determine the decay rate of the pulses), to trigger an emergency shut off of the microstimulator. Also described are methods and apparatuses for regulating the temperature of an implant based applied power from a charger (e.g., voltage across the charger when unloaded and when loaded by the implant) to yield a power control loop correlated with the power drawn by the implant to determine temperature of the implant. A negotiation protocol can exchange data between the charger and the implant (e.g., type of charger, type of implant, nature of the coupling between the two, etc.) to set target power control loop parameters to estimate and regulate implant temperature.
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公开(公告)号：US20160038745A1
公开(公告)日：2016-02-11
申请号：US14887192
申请日：2015-10-19
申请人： Michael A. FALTYS , Jesse M. SIMON , Yiming LIU
发明人： Michael A. FALTYS , Jesse M. SIMON , Yiming LIU
CPC分类号： A61N1/3787 , A61N1/0556 , A61N1/36053 , A61N1/3606 , A61N1/36125 , A61N1/36142 , A61N1/36175 , A61N1/37205 , A61N1/37235 , A61N1/375 , A61N1/3756
摘要： A system for treating chronic inflammation may include an implantable microstimulator, a wearable charger, and optionally an external controller. The implantable microstimulator may be implemented as a leadless neurostimulator implantable in communication with a cervical region of a vagus nerve. The microstimulator can address several types of stimulation including regular dose delivery. The wearable charger may be worn around the subject's neck to rapidly (
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7.发明申请公开(公告)号：US20150057722A1
公开(公告)日：2015-02-26
申请号：US14508940
申请日：2014-10-07
申请人： Michael A. FALTYS , Jesse M. SIMON , Yiming LIU
发明人： Michael A. FALTYS , Jesse M. SIMON , Yiming LIU
CPC分类号： A61N1/3787 , A61N1/0556 , A61N1/36053 , A61N1/3606 , A61N1/36125 , A61N1/36142 , A61N1/36175 , A61N1/37205 , A61N1/37235 , A61N1/375 , A61N1/3756
摘要： A system for treating chronic inflammation may include an implantable microstimulator, a wearable charger, and optionally an external controller. The implantable microstimulator may be implemented as a leadless neurostimulator implantable in communication with a cervical region of a vagus nerve. The microstimulator can address several types of stimulation including regular dose delivery. The wearable charger may be worn around the subject's neck to rapidly (
摘要翻译： 用于治疗慢性炎症的系统可以包括可植入微型刺激器，可穿戴充电器和任选的外部控制器。 可植入微刺激器可以被实现为可植入与迷走神经的子宫颈区域连通的无引导神经刺激器。 微型刺激器可以解决几种类型的刺激，包括定期给药。 穿戴式充电器可能会在受试者颈部周围快速穿戴（每周<10分钟），对植入的微型刺激器进行充电。 外部控制器可以被配置为控制微型激励器的剂量和活性的处方垫。
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8.发明申请公开(公告)号：US20140074186A1
公开(公告)日：2014-03-13
申请号：US14082047
申请日：2013-11-15
申请人： Michael A. FALTYS , Jesse M. SIMON , Yiming LIU
发明人： Michael A. FALTYS , Jesse M. SIMON , Yiming LIU
CPC分类号： A61N1/3787 , A61N1/0556 , A61N1/36053 , A61N1/3606 , A61N1/36125 , A61N1/36142 , A61N1/36175 , A61N1/37205 , A61N1/37235 , A61N1/375 , A61N1/3756
摘要： A system for treating chronic inflammation may include an implantable microstimulator, a wearable charger, and optionally an external controller. The implantable microstimulator may be implemented as a leadless neurostimulator implantable in communication with a cervical region of a vagus nerve. The microstimulator can address several types of stimulation including regular dose delivery. The wearable charger may be worn around the subject's neck to rapidly (
摘要翻译： 用于治疗慢性炎症的系统可以包括可植入微型刺激器，可穿戴充电器和任选的外部控制器。 可植入微刺激器可以被实现为可植入与迷走神经的子宫颈区域连通的无引导神经刺激器。 微型刺激器可以解决几种类型的刺激，包括定期给药。 穿戴式充电器可能会在受试者颈部周围快速穿戴（每周<10分钟），对植入的微型刺激器进行充电。 外部控制器可以被配置为控制微型激励器的剂量和活性的处方垫。
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公开(公告)号：US20180289970A1
公开(公告)日：2018-10-11
申请号：US16005191
申请日：2018-06-11
申请人： Michael A. FALTYS , Jesse M. SIMON , Yiming LIU
发明人： Michael A. FALTYS , Jesse M. SIMON , Yiming LIU
CPC分类号： A61N1/3787 , A61N1/0556 , A61N1/36053 , A61N1/3606 , A61N1/36125 , A61N1/36142 , A61N1/36175 , A61N1/37205 , A61N1/37235 , A61N1/375 , A61N1/3756
摘要： A system for treating chronic inflammation may include an implantable microstimulator, a wearable charger, and optionally an external controller. The implantable microstimulator may be implemented as a leadless neurostimulator implantable in communication with a cervical region of a vagus nerve. The microstimulator can address several types of stimulation including regular dose delivery. The wearable charger may be worn around the subject's neck to rapidly (
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