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公开(公告)号：US10287269B2
公开(公告)日：2019-05-14
申请号：US15559284
申请日：2016-03-21
Applicant: Merck Sharp & Dohme Corp.
Inventor： Dong-Ming Shen , Jonathan E. Wilson , Meng Yang , Dann Parker , Zack Zhiqiang Guo , Alejandro Crespo , Deping Wang , Troy McCracken
IPC: C07D403/04 , C07D401/14 , C07D405/14
Abstract: The present invention is directed to pyrimidine carboxamide compounds of formula I which are useful as therapeutic agents for the treatment of central nervous system disorders associated with phosphodiesterase 2 (PDE2). The present invention also relates to the use of such compounds for treating neurological and psychiatric disorders, such as schizophrenia, psychosis, Parkinson's disease, Parkinson's disease dementia (PDD), or Huntington's disease, and those associated with striatal hypofunction or basal ganglia dysfunction.
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公开(公告)号：US20170015633A1
公开(公告)日：2017-01-19
申请号：US15107233
申请日：2014-12-17
Applicant: Merck Sharp & Dohme Corp. , MSD R&D (China) Co. Ltd.
Inventor： Dong Ming Shen , Melissa Egbertson , Richard Berger , XiaoXia Qian , Yimin Qian , Bart Harper , Meng Yang , Zack Zhi Qiang Guo , Vanessa L. Rada , Deping Wang , Timothy A. Cernak , Christopher Sinz , Ming Wang , Jonathan E. Wilson , Shimin Xu
IPC: C07D239/36 , C07D401/12 , C07D403/04 , C07D403/06 , C07D487/04 , C07D403/14 , C07D405/12 , C07D405/14 , C07D413/04 , C07D417/04 , C07D401/06 , C07D403/12
CPC classification number: C07D239/36 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D413/04 , C07D417/04 , C07D487/04
Abstract: Disclosed are pyrimidine carboxamide compounds of formula (I) which are useful as therapeutic agents for the treatment of central nervous system disorders associated with phosphodiesterase 2 (PDE2), pharmaceutical compositions and uses thereof.
Abstract translation: 公开了式（I）的嘧啶羧酰胺化合物，其可用作治疗与磷酸二酯酶2（PDE2）相关的中枢神经系统疾病，药物组合物及其用途的治疗剂。
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公开(公告)号：US20180057480A1
公开(公告)日：2018-03-01
申请号：US15559284
申请日：2016-03-21
Applicant: Merck Sharp & Dohme Corp.
Inventor： Dong-Ming Shen , Jonathan E. Wilson , Meng Yang , Dann Parker , Zack Zhiqiang Guo , Alejandro Crespo , Deping Wang , Troy McCracken
IPC: C07D403/04 , C07D405/14 , C07D401/14
CPC classification number: C07D403/04 , C07D401/14 , C07D405/14
Abstract: The present invention is directed to pyrimidine carboxamide compounds of formula I which are useful as therapeutic agents for the treatment of central nervous system disorders associated with phosphodiesterase 2 (PDE2). The present invention also relates to the use of such compounds for treating neurological and psychiatric disorders, such as schizophrenia, psychosis, Parkinson's disease, Parkinson's disease dementia (PDD), or Huntington's disease, and those associated with striatal hypofunction or basal ganglia dysfunction.
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公开(公告)号：US10351558B2
公开(公告)日：2019-07-16
申请号：US15550862
申请日：2016-02-12
Applicant: Merck Sharp & Dohme Corp. , Dongfang Meng , Hong Li , Meng Yang , Manuel de Lera Ruiz , Sunita V. Dewnani , Tianying Jian , Dann L. Parker, Jr. , Ting Zhang , Louis-Charles Campeau , Harold B. Wood , Jiayi Xu , Richard Berger , Jane Yang Wu , Robert K. Orr , Shawn P. Walsh , Bart Harper
Inventor： Dongfang Meng , Hong Li , Meng Yang , Manuel de Lera Ruiz , Sunita V. Dewnani , Tianying Jian , Dann L. Parker, Jr. , Ting Zhang , Louis-Charles Campeau , Harold B. Wood , Jiayi Xu , Richard Berger , Jane Yang Wu , Robert K. Orr , Shawn P. Walsh , Bart Harper
IPC: C07D471/04 , C07D403/12 , C07D417/14 , A61P9/00 , C07D413/14 , C07D471/14 , C07D498/04 , C07D513/04
Abstract: The present invention provides a compound of Formula I and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing unstable angina, refractory angina, myocardial infarction, transient ischemic attacks, atrial fibrillation, thrombotic stroke, embolic stroke, deep vein thrombosis, disseminated intravascular coagulation, ocular build up of fibrin, and reocclusion or restenosis of recanalized vessels. The compounds are selective Factor IXa inhibitors.
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公开(公告)号：US10285989B2
公开(公告)日：2019-05-14
申请号：US15573858
申请日：2016-05-10
Applicant: Merck Sharp & Dohme Corp.
Inventor： Dong-Ming Shen , Deping Wang , XiaoXia Qian , Bart Harper , Meng Yang , Yingjian Bo
IPC: C07D403/12 , A61K31/513 , C07D401/12 , C07D403/04 , C07D405/12 , C07D239/38 , C07D239/42 , C07D239/52 , C07D487/04 , A61P25/28 , A61P25/22 , A61P25/18 , A61P25/16 , A61P25/06
Abstract: The present invention is directed to pyrimidinone amide compounds which may be useful as therapeutic agents for the treatment of central nervous system and/or peripheral disorders associated with phosphodiesterase 2 (PDE2). The present invention also relates to the use of such compounds for treating neurological and psychiatric disorders, such as schizophrenia, psychosis, Alzheimer's, cognitive impairment, anxiety, depression, migraines, or Huntington's disease, Parkinson's disease, Parkinson's disease dementia (PDD), and other diseases associated with striatal hypofunction or basal ganglia dysfunction.
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Patent Agency Ranking
公开(公告)号：US20180022747A1
公开(公告)日：2018-01-25
申请号：US15550862
申请日：2016-02-12
Applicant: Dongfang MENG , Hong LI , Meng YANG , Manuel de Lera RUIZ , Sunita V. DEWNANI , Tianying JIAN , Dann L. PARKER, JR. , Ting ZHANG , Louis-Charles CAMPEAU , Bart HARPER , Harold B. WOOD , Jiayi XU , Richard BERGER , Jane Yang WU , Robert K. ORR , Shawn P. WALSH , Merck Sharp & Dohme Corp.
Inventor： Dongfang Meng , Hong Li , Meng Yang , Manuel de Lera Ruiz , Sunita V. Dewnani , Tianying Jian , Dann L. Parker, Jr. , Ting Zhang , Louis-Charles Campeau , Harold B. Wood , Jiayi Xu , Richard Berger , Jane Yang Wu , Robert K. Orr , Shawn P. Walsh , Bart Harper
IPC: C07D471/04 , C07D403/12 , C07D498/04 , C07D417/14 , C07D513/04 , C07D471/14 , C07D413/14
CPC classification number: C07D471/04 , A61P9/00 , C07D403/12 , C07D413/14 , C07D417/14 , C07D471/14 , C07D498/04 , C07D513/04
Abstract: The present invention provides a compound of Formula I and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing unstable angina, refractory angina, myocardial infarction, transient ischemic attacks, atrial fibrillation, thrombotic stroke, embolic stroke, deep vein thrombosis, disseminated intravascular coagulation, ocular build up of fibrin, and reocclusion or restenosis of recanalized vessels. The compounds are selective Factor IXa inhibitors.
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公开(公告)号：US20220235033A1
公开(公告)日：2022-07-28
申请号：US17613988
申请日：2020-05-26
Applicant: Merck Sharp & Dohme Corp.
Inventor： Jacqueline D. Hicks , John S. Debenham , Amjad Ali , Lan Wei , Tianying Jian , Dexi Yang , Anthony K. Ogawa , Wenlang Fu , Matthew Lombardo , Rongze Kuang , Meng Yang , Sung-Sau So , Kenneth Ellsworth , Peter Nizner , Daniel A. Tatosian , Robert R. Wilkening , Jun Wang
IPC: C07D401/14 , C07D405/14 , C07D471/04 , C07D413/14 , C07D417/14
Abstract: The present invention provides a compound of Formula (I) and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XI activation inhibitors.
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公开(公告)号：US10214512B2
公开(公告)日：2019-02-26
申请号：US15771538
申请日：2016-10-24
Applicant: MERCK SHARP & DOHME CORP.
Inventor： Jiayi Xu , Amjad Ali , Wei Zhou , Ying-Duo Gao , Scott D. Edmondson , Eric Mertz , Santhosh F. Neelamkavil , Weiguo Liu , Wanying Sun , Dong-Ming Shen , Bart Harper , Cheng Zhu , Thomas Bara , Yeon-Hee Lim , Meng Yang
IPC: C07D471/08 , C07D471/18 , C07D401/14 , A61P7/02 , C07D487/08 , C07D413/14 , C07D401/04
Abstract: The present invention provides a compound of Formula (I) and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XIa inhibitors or dual inhibitors of Factor XIa and plasma Kallikrein.
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公开(公告)号：US10143681B2
公开(公告)日：2018-12-04
申请号：US15681478
申请日：2017-08-21
Applicant: MERCK SHARP & DOHME CORP.
Inventor： Dong-Ming Shen , Rongze Kuang , Puneet Kumar , Joseph L. Duffy , Cheng Zhu , Amjad Ali , Meng Yang , John S. Debenham
IPC: A61K31/4412 , C07D213/89 , A61K31/435
Abstract: The present invention provides a compound of Formula I and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XIa inhibitors or dual inhibitors of Factor XIa and plasma kallikrein.
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公开(公告)号：US20180256575A1
公开(公告)日：2018-09-13
申请号：US15573858
申请日：2016-05-10
Applicant: Merck Sharp & Dohme Corp.
Inventor： Dong-Ming Shen , Deping Wang , XiaoXia Qian , Bart Harper , Meng Yang , Yingjian Bo
CPC classification number: A61K31/513 , A61P25/06 , A61P25/16 , A61P25/18 , A61P25/22 , A61P25/28 , C07D239/38 , C07D239/42 , C07D239/52 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/12 , C07D487/04
Abstract: The present invention is directed to pyrimidinone amide compounds which may be useful as therapeutic agents for the treatment of central nervous system and/or peripheral disorders associated with phosphodiesterase 2 (PDE2). The present invention also relates to the use of such compounds for treating neurological and psychiatric disorders, such as schizophrenia, psychosis, Alzheimer's, cognitive impairment, anxiety, depression, migraines, or Huntington's disease, Parkinson's disease, Parkinson's disease dementia (PDD), and other diseases associated with striatal hypofunction or basal ganglia dysfunction.
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