公开(公告)号：US20220235033A1

公开(公告)日：2022-07-28

申请号：US17613988

申请日：2020-05-26

Applicant: Merck Sharp & Dohme Corp.

Inventor： Jacqueline D. Hicks ,  John S. Debenham ,  Amjad Ali ,  Lan Wei ,  Tianying Jian ,  Dexi Yang ,  Anthony K. Ogawa ,  Wenlang Fu ,  Matthew Lombardo ,  Rongze Kuang ,  Meng Yang ,  Sung-Sau So ,  Kenneth Ellsworth ,  Peter Nizner ,  Daniel A. Tatosian ,  Robert R. Wilkening ,  Jun Wang

IPC: C07D401/14 ,  C07D405/14 ,  C07D471/04 ,  C07D413/14 ,  C07D417/14

Abstract: The present invention provides a compound of Formula (I) and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XI activation inhibitors.