公开(公告)号：US10450335B2

公开(公告)日：2019-10-22

申请号：US16061732

申请日：2016-12-12

Applicant: Merck Sharp & Dohme Corp.

Inventor： Wenlang Fu ,  Zhiqiang Guo ,  Ning Qi ,  Izzat T. Raheem ,  Petr Vachal ,  Ming Wang ,  John D. Schreier

IPC: C07F9/655 ,  A61K31/675 ,  A61P31/18 ,  C07F9/6561 ,  A61K45/06

Abstract: Compounds of Formula I: I and their pharmaceutically acceptable salts are useful for the inhibition of HIV reverse transcriptase. The compounds may also be useful for the prophylaxis or treatment of infection by HIV and in the prophylaxis, delay in the onset or progression, and treatment of AIDS. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antiviral agents, immunomodulators, antibiotics or vaccines.

公开(公告)号：US20180362563A1

公开(公告)日：2018-12-20

申请号：US16061732

申请日：2016-12-12

Applicant: Merck Sharp & Dohme Corp.

Inventor： Wenlang Fu ,  Zhiqiang Guo ,  Ning Qi ,  Izzat T. Raheem ,  Petr Vachal ,  Ming Wang ,  John D. Schreier

IPC: C07F9/6561 ,  A61K45/06 ,  A61P31/18 ,  A61K31/675

CPC classification number: C07F9/65616 ,  A61K31/675 ,  A61K45/06 ,  A61P31/18

Abstract: Compounds of Formula I: I and their pharmaceutically acceptable salts are useful for the inhibition of HIV reverse transcriptase. The compounds may also be useful for the prophylaxis or treatment of infection by HV and in the prophylaxis, delay in the onset or progression, and treatment of AIDS. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antiviral agents, immunomodulators, antibiotics or vaccines.

公开(公告)号：US20220235033A1

公开(公告)日：2022-07-28

申请号：US17613988

申请日：2020-05-26

Applicant: Merck Sharp & Dohme Corp.

Inventor： Jacqueline D. Hicks ,  John S. Debenham ,  Amjad Ali ,  Lan Wei ,  Tianying Jian ,  Dexi Yang ,  Anthony K. Ogawa ,  Wenlang Fu ,  Matthew Lombardo ,  Rongze Kuang ,  Meng Yang ,  Sung-Sau So ,  Kenneth Ellsworth ,  Peter Nizner ,  Daniel A. Tatosian ,  Robert R. Wilkening ,  Jun Wang

IPC: C07D401/14 ,  C07D405/14 ,  C07D471/04 ,  C07D413/14 ,  C07D417/14

Abstract: The present invention provides a compound of Formula (I) and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XI activation inhibitors.