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公开(公告)号：US20220235033A1
公开(公告)日：2022-07-28
申请号：US17613988
申请日：2020-05-26
Applicant: Merck Sharp & Dohme Corp.
Inventor： Jacqueline D. Hicks , John S. Debenham , Amjad Ali , Lan Wei , Tianying Jian , Dexi Yang , Anthony K. Ogawa , Wenlang Fu , Matthew Lombardo , Rongze Kuang , Meng Yang , Sung-Sau So , Kenneth Ellsworth , Peter Nizner , Daniel A. Tatosian , Robert R. Wilkening , Jun Wang
IPC: C07D401/14 , C07D405/14 , C07D471/04 , C07D413/14 , C07D417/14
Abstract: The present invention provides a compound of Formula (I) and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XI activation inhibitors.
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公开(公告)号：US20200317811A1
公开(公告)日：2020-10-08
申请号：US16864559
申请日：2020-05-01
Applicant: Merck Sharp & Dohme Corp. , Adimab, LLC
Inventor： Zhu Chen , Kenneth Ellsworth , James Milligan , Elizabeth Oldham , Dietmar Seiffert , Vaishnavi Ganti , Mohammad Tabrizifard , Bianka Prinz
IPC: C07K16/36 , A61K39/395
Abstract: Antibodies that bind the apple 3 domain of human coagulation Factor XI and inhibit activation of FXI by coagulation factor XIIa as well as activation of FIX by FXIa are described.
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公开(公告)号：US11479615B2
公开(公告)日：2022-10-25
申请号：US16864583
申请日：2020-05-01
Applicant: Merck Sharp & Dohme Corp. , Adimab, LLC
Inventor： Zhu Chen , Kenneth Ellsworth , James Milligan , Elizabeth Oldham , Dietmar Seiffert , Bianka Prinz
IPC: C07K16/36 , A61K39/395 , A61K39/00
Abstract: Antibodies that bind the apple 3 domain of human coagulation Factor XI and inhibit activation of FXI by coagulation factor XIIa as well as activation of FIX by FXIa are described.
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公开(公告)号：US20200270364A1
公开(公告)日：2020-08-27
申请号：US16864570
申请日：2020-05-01
Applicant: Merck Sharp & Dohme Corp. , Adimab, LLC
Inventor： Zhu Chen , Kenneth Ellsworth , James Milligan , Elizabeth Oldham , Dietmar Seiffert , Vaishnavi Ganti , Mohammad Tabrizifard , Bianka Prinz
IPC: C07K16/36 , A61K39/395
Abstract: Antibodies that bind the apple 3 domain of human coagulation Factor XI and inhibit activation of FXI by coagulation factor XIIa as well as activation of FIX by FXIa are described.
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公开(公告)号：US11512142B2
公开(公告)日：2022-11-29
申请号：US16864570
申请日：2020-05-01
Applicant: Merck Sharp & Dohme Corp. , Adimab, LLC
Inventor： Zhu Chen , Kenneth Ellsworth , James Milligan , Elizabeth Oldham , Dietmar Seiffert , Bianka Prinz
IPC: C07K16/36 , A61K39/395 , A61K39/00
Abstract: Antibodies that bind the apple 3 domain of human coagulation Factor XI and inhibit activation of FXI by coagulation factor XIIa as well as activation of FIX by FXIa are described.
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Patent Agency Ranking
公开(公告)号：US20200308302A1
公开(公告)日：2020-10-01
申请号：US16864577
申请日：2020-05-01
Applicant: Merck Sharp & Dohme Corp. , Adimab, LLC
Inventor： Zhu Chen , Kenneth Ellsworth , James Milligan , Elizabeth Oldham , Dietmar Seiffert , Vaishnavi Ganti , Mohammad Tabrizifard , Bianka Prinz
IPC: C07K16/36 , A61K39/395
Abstract: Antibodies that bind the apple 3 domain of human coagulation Factor XI and inhibit activation of FXI by coagulation factor XIIa as well as activation of FIX by FXIa are described.
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公开(公告)号：US10676536B2
公开(公告)日：2020-06-09
申请号：US15619620
申请日：2017-06-12
Applicant: Merck Sharp & Dohme Corp. , Adimab, LLC
Inventor： Zhu Chen , Kenneth Ellsworth , James Milligan , Elizabeth Oldham , Dietmar Seiffert , Bianka Prinz
IPC: C07K16/36 , A61K39/395 , A61K39/00
Abstract: Antibodies that bind the apple 3 domain of human coagulation Factor XI and inhibit activation of FXI by coagulation factor XIIa as well as activation of FIX by FXIa are described.
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公开(公告)号：US20170355780A1
公开(公告)日：2017-12-14
申请号：US15619620
申请日：2017-06-12
Applicant: Merck Sharp & Dohme Corp.
Inventor： Zhu Chen , Kenneth Ellsworth , James Milligan , Elizabeth Oldham , Dietmar Seiffert , Vaishnavi Ganti , Mohammad Tabrizifard
IPC: C07K16/36 , A61K39/395 , A61K39/00
Abstract: Antibodies that bind the apple 3 domain of human coagulation Factor XI and inhibit activation of FXI by coagulation factor XIIa as well as activation of FIX by FXIa are described.
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公开(公告)号：US11485794B2
公开(公告)日：2022-11-01
申请号：US16864577
申请日：2020-05-01
Applicant: Merck Sharp & Dohme Corp. , Adimab, LLC
Inventor： Zhu Chen , Kenneth Ellsworth , James Milligan , Elizabeth Oldham , Dietmar Seiffert , Bianka Prinz
IPC: C07K16/36 , A61K39/395 , A61K39/00
Abstract: Antibodies that bind the apple 3 domain of human coagulation Factor XI and inhibit activation of FXI by coagulation factor XIIa as well as activation of FIX by FXIa are described.
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公开(公告)号：US20200255542A1
公开(公告)日：2020-08-13
申请号：US16864583
申请日：2020-05-01
Applicant: Merck Sharp & Dohme Corp. , Adimab, LLC
Inventor： Zhu Chen , Kenneth Ellsworth , James Milligan , Elizabeth Oldham , Dietmar Seiffert , Vaishnavi Ganti , Mohammad Tabrizifard , Bianka Prinz
IPC: C07K16/36 , A61K39/395
Abstract: Antibodies that bind the apple 3 domain of human coagulation Factor XI and inhibit activation of FXI by coagulation factor XIIa as well as activation of FIX by FXIa are described.
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