公开(公告)号：US20190352294A1

公开(公告)日：2019-11-21

申请号：US16461849

申请日：2017-11-13

Applicant: Ashwin RAO ,  Brian Alexander MCKITTRICK ,  Matthew LOMBARDO ,  Jacqueline D. HICKS ,  Amy Bittner MCCRACKEN ,  Hong Dong CHU ,  Sung-Sau SO ,  Peter ORTH ,  Zhicai WU ,  Ping LAN ,  John S. DEBENHAM ,  Brent R. WHITEHEAD ,  Jerry A. TAYLOR ,  Zhongxiang SUN ,  Revathi Reddy KATIPALLY ,  Jonathan E. GABLE ,  Markus K. DAHLGREN ,  Sathesh P. BHAT ,  Merck Sharp & Dohme Corp.

Inventor： Ashwin U. Rao ,  Brian Alexander McKittrick ,  Matthew Lombardo ,  Jacqueline D. Hicks ,  Amy Bittner McCracken ,  Hong Dong Chu ,  Sung-Sau So ,  Peter Orth ,  Zhicai Wu ,  Ping Lan ,  John S. Debenham ,  Brent R. Whitehead ,  Jerry A. Taylor ,  Zhongxiang Sun ,  Revathi Reddy Katipally ,  Jonathan E. Gable ,  Markus K. Dahlgren ,  Sathesh P. Bhat

IPC: C07D413/14 ,  C07D495/04 ,  A61P7/02

Abstract: The present invention provides a compound of Formula (I) and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XIIa inhibitors.

公开(公告)号：US20170210732A1

公开(公告)日：2017-07-27

申请号：US15329634

申请日：2015-07-23

Applicant: Merck Sharp & Dohme Corp.

Inventor： Weiguo Liu ,  Scott D. Edmondson ,  Zhuyan Guo ,  Sung-Sau So ,  Anthony K. Ogawa ,  Rongze Kuang ,  Heping Wu ,  Amjad Ali ,  Ying-Duo Gao ,  Yu Jiang ,  Chunsing Li ,  Tingting Yu

IPC: C07D409/14 ,  C07D401/06 ,  C07D401/14 ,  C07D417/14 ,  C07D413/14

CPC classification number: C07D409/14 ,  A61P7/02 ,  C07D401/06 ,  C07D401/14 ,  C07D413/14 ,  C07D417/14

Abstract: The present invention provides a compound of Formula (I) and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XIa inhibitors or dual inhibitors of Factor XIa and plasma kallikrein.

公开(公告)号：US20170197953A1

公开(公告)日：2017-07-13

申请号：US15312839

申请日：2015-05-22

Applicant: MERCK SHARP &DOHME CORP.

Inventor： Weiguo Liu ,  Scott D. Edmondson ,  Zhuyan Guo ,  Eric Mertz ,  Anthony K. Ogawa ,  Sung-Sau So ,  Wanying Sun ,  Linda L. Brockunier ,  Amjad Ali ,  Rongze Kuang ,  Heping Wu

IPC: C07D417/10 ,  C07D413/10 ,  C07D401/12 ,  C07D401/14 ,  C07D401/10 ,  C07D213/89

CPC classification number: C07D417/10 ,  C07D213/89 ,  C07D401/10 ,  C07D401/12 ,  C07D401/14 ,  C07D413/10

Abstract: The present invention provides a compound of Formula I (The chemical formula should be inserted here.) and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XIa inhibitors or dual inhibitors of Factor XIa and plasma kallikrein.

公开(公告)号：US10123995B2

公开(公告)日：2018-11-13

申请号：US15542948

申请日：2016-01-15

Applicant: MERCK SHARP & DOHME CORP.

Inventor： Eric Mertz ,  Weiguo Liu ,  Scott D. Edmondson ,  Amjad Ali ,  Ying-Duo Gao ,  Santhosh F. Neelamkavil ,  Sung-Sau So ,  Remond Moningka ,  Wanying Sun ,  Alan Hruza ,  Linda L. Brockunier

IPC: A61K31/435 ,  A61K31/4375 ,  A61K31/195 ,  A61P7/02 ,  A61P7/04 ,  C07D221/18 ,  C07D221/04 ,  C07D401/10

Abstract: The present invention provides a compound of Formula (I) and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XIa inhibitors or dual inhibitors of Factor XIa and plasma kallikrein.

公开(公告)号：US20180079743A1

公开(公告)日：2018-03-22

申请号：US15565748

申请日：2016-04-11

Applicant: MERCK SHARP & DOHME CORP.

Inventor： Eric Mertz ,  Scott D. Edmondson ,  Sung-Sau So ,  Wanying Sun ,  Weiguo Liu ,  Santhosh F. Neelamkavil ,  Ying-Duo Gao ,  Alan Hruza ,  Yi Zang ,  Amjad Ali ,  Rudrajit Mal ,  Jiafang He ,  Rongze Kuang ,  Heping Wu ,  Anthony K. Ogawa ,  Andrew F. Nolting

IPC: C07D401/14 ,  C07D409/14 ,  C07D413/14

CPC classification number: C07D401/14 ,  C07D409/14 ,  C07D413/14

Abstract: The present invention provides a compound of Formula (I); and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XIa inhibitors or dual inhibitors of Factor XIa and plasma kallikrein.

公开(公告)号：US20180000795A1

公开(公告)日：2018-01-04

申请号：US15542948

申请日：2016-01-15

Applicant: MERCK SHARP & DOHME CORP.

Inventor： Eric Mertz ,  Weiguo Liu ,  Scott D. Edmondson ,  Amjad Ali ,  Ying-Duo Gao ,  Santhosh F. Neelamkavil ,  Sung-Sau So ,  Remond Moningka ,  Wanying Sun ,  Alan Hruza ,  Linda L. Brockunier

IPC: A61K31/435 ,  A61K31/195 ,  C07D221/18 ,  C07D401/10

CPC classification number: A61K31/435 ,  A61K31/195 ,  A61K31/4375 ,  A61P7/02 ,  A61P7/04 ,  C07D221/04 ,  C07D221/18 ,  C07D401/10

Abstract: The present invention provides a compound of Formula (I) and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XIa inhibitors or dual inhibitors of Factor XIa and plasma kallikrein.

公开(公告)号：US20170240523A1

公开(公告)日：2017-08-24

申请号：US15329635

申请日：2015-07-23

Applicant: Merck Sharp & Dohme Corp.

Inventor： Weiguo Liu ,  Scott D Edmondson ,  Zhuyan Guo ,  Alan Hruza ,  Sung-Sau So ,  Wanying Sun ,  Amjad All ,  Rongze Kuang ,  Ying-Duo Gao ,  Anthony K Ogawa

IPC: C07D401/06 ,  C07D401/14

CPC classification number: C07D401/06 ,  C07D401/14

Abstract: The present invention provides a compound of Formula (I) and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoaguability or fibrotic changes. The compounds are selective Factor XIa inhibitors or dual inhibitors of Factor XIa and plasma kallikrein.

公开(公告)号：US10081617B2

公开(公告)日：2018-09-25

申请号：US15565748

申请日：2016-04-11

Applicant: MERCK SHARP & DOHME CORP.

Inventor： Eric Mertz ,  Scott D. Edmondson ,  Sung-Sau So ,  Wanying Sun ,  Weiguo Liu ,  Santhosh F. Neelamkavil ,  Ying-Duo Gao ,  Alan Hruza ,  Yi Zang ,  Amjad Ali ,  Rudrajit Mal ,  Jiafang He ,  Rongze Kuang ,  Heping Wu ,  Anthony K. Ogawa ,  Andrew F. Nolting

IPC: C07D401/14 ,  C07D413/14 ,  C07D409/14

Abstract: The present invention provides a compound of Formula (I); and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XIa inhibitors or dual inhibitors of Factor XIa and plasma kallikrein.

公开(公告)号：US09868727B2

公开(公告)日：2018-01-16

申请号：US15329634

申请日：2015-07-23

Applicant: Merck Sharp & Dohme Corp.

Inventor： Weiguo Liu ,  Scott D. Edmondson ,  Zhuyan Guo ,  Sung-Sau So ,  Anthony K. Ogawa ,  Rongze Kuang ,  Heping Wu ,  Amjad Ali ,  Ying-Duo Gao ,  Yu Jiang ,  Chunsing Li ,  Tingting Yu

IPC: C07D409/14 ,  C07D417/14 ,  C07D413/14 ,  C07D401/14 ,  C07D401/06 ,  A61K31/4439 ,  A61K31/444

CPC classification number: C07D409/14 ,  A61P7/02 ,  C07D401/06 ,  C07D401/14 ,  C07D413/14 ,  C07D417/14

Abstract: The present invention provides a compound of Formula (I) and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XIa inhibitors or dual inhibitors of Factor XIa and plasma kallikrein.

公开(公告)号：US09783530B2

公开(公告)日：2017-10-10

申请号：US15312839

申请日：2015-05-22

Applicant: Merck Sharp & Dohme Corp.

Inventor： Weiguo Liu ,  Scott D. Edmondson ,  Zhuyan Guo ,  Eric Mertz ,  Anthony K. Ogawa ,  Sung-Sau So ,  Wanying Sun ,  Linda L. Brockunier ,  Amjad Ali ,  Rongze Kuang ,  Heping Wu

IPC: C07D417/10 ,  C07D401/10 ,  C07D213/89 ,  C07D401/12 ,  C07D401/14 ,  C07D413/10

CPC classification number: C07D417/10 ,  C07D213/89 ,  C07D401/10 ,  C07D401/12 ,  C07D401/14 ,  C07D413/10

Abstract: The present invention provides a compound of Formula I (The chemical formula should be inserted here.) and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XIa inhibitors or dual inhibitors of Factor XIa and plasma kallikrein.