公开(公告)号：US20190352294A1

公开(公告)日：2019-11-21

申请号：US16461849

申请日：2017-11-13

Applicant: Ashwin RAO ,  Brian Alexander MCKITTRICK ,  Matthew LOMBARDO ,  Jacqueline D. HICKS ,  Amy Bittner MCCRACKEN ,  Hong Dong CHU ,  Sung-Sau SO ,  Peter ORTH ,  Zhicai WU ,  Ping LAN ,  John S. DEBENHAM ,  Brent R. WHITEHEAD ,  Jerry A. TAYLOR ,  Zhongxiang SUN ,  Revathi Reddy KATIPALLY ,  Jonathan E. GABLE ,  Markus K. DAHLGREN ,  Sathesh P. BHAT ,  Merck Sharp & Dohme Corp.

Inventor： Ashwin U. Rao ,  Brian Alexander McKittrick ,  Matthew Lombardo ,  Jacqueline D. Hicks ,  Amy Bittner McCracken ,  Hong Dong Chu ,  Sung-Sau So ,  Peter Orth ,  Zhicai Wu ,  Ping Lan ,  John S. Debenham ,  Brent R. Whitehead ,  Jerry A. Taylor ,  Zhongxiang Sun ,  Revathi Reddy Katipally ,  Jonathan E. Gable ,  Markus K. Dahlgren ,  Sathesh P. Bhat

IPC: C07D413/14 ,  C07D495/04 ,  A61P7/02

Abstract: The present invention provides a compound of Formula (I) and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XIIa inhibitors.

公开(公告)号：US20130109649A1

公开(公告)日：2013-05-02

申请号：US13660010

申请日：2012-10-25

Applicant: Pengcheng Patrick Shao ,  Wanying Sun ,  Revathi Reddy Katipally ,  Petr Vachal ,  Feng Ye ,  Jian Liu ,  Deyou Sha

Inventor： Pengcheng Patrick Shao ,  Wanying Sun ,  Revathi Reddy Katipally ,  Petr Vachal ,  Feng Ye ,  Jian Liu ,  Deyou Sha

IPC: A61K31/424 ,  A61K31/4439 ,  A61K31/506 ,  A61K31/454 ,  A61K31/5355 ,  A61K31/519 ,  A61P9/10 ,  A61P3/06 ,  A61K31/437 ,  A61K31/444 ,  A61K31/455 ,  A61K31/714 ,  C07D498/04 ,  A61K31/4245

CPC classification number: C07D498/04 ,  A61K31/424 ,  A61K31/437 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/506 ,  A61K45/06

Abstract: Compounds having the structure of Formula I, including pharmaceutically acceptable salts of the compounds, are CETP inhibitors and are useful for raising HDL-cholesterol, reducing LDL-cholesterol, and for treating or preventing atherosclerosis.

Abstract translation: 具有式I结构的化合物，包括化合物的药学上可接受的盐，是CETP抑制剂，可用于培养HDL-胆固醇，降低LDL-胆固醇，以及用于治疗或预防动脉粥样硬化。