公开(公告)号：US20190352294A1

公开(公告)日：2019-11-21

申请号：US16461849

申请日：2017-11-13

Applicant: Ashwin RAO ,  Brian Alexander MCKITTRICK ,  Matthew LOMBARDO ,  Jacqueline D. HICKS ,  Amy Bittner MCCRACKEN ,  Hong Dong CHU ,  Sung-Sau SO ,  Peter ORTH ,  Zhicai WU ,  Ping LAN ,  John S. DEBENHAM ,  Brent R. WHITEHEAD ,  Jerry A. TAYLOR ,  Zhongxiang SUN ,  Revathi Reddy KATIPALLY ,  Jonathan E. GABLE ,  Markus K. DAHLGREN ,  Sathesh P. BHAT ,  Merck Sharp & Dohme Corp.

Inventor： Ashwin U. Rao ,  Brian Alexander McKittrick ,  Matthew Lombardo ,  Jacqueline D. Hicks ,  Amy Bittner McCracken ,  Hong Dong Chu ,  Sung-Sau So ,  Peter Orth ,  Zhicai Wu ,  Ping Lan ,  John S. Debenham ,  Brent R. Whitehead ,  Jerry A. Taylor ,  Zhongxiang Sun ,  Revathi Reddy Katipally ,  Jonathan E. Gable ,  Markus K. Dahlgren ,  Sathesh P. Bhat

IPC: C07D413/14 ,  C07D495/04 ,  A61P7/02

Abstract: The present invention provides a compound of Formula (I) and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XIIa inhibitors.