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    Modified binding proteins inhibiting the VEGF-A receptor interaction
    1.
    发明授权
    Modified binding proteins inhibiting the VEGF-A receptor interaction 有权
    抑制VEGF-A受体相互作用的修饰结合蛋白

    公开(公告)号：US09289466B2

    公开(公告)日：2016-03-22

    申请号：US14206054

    申请日：2014-03-12

    Applicant: MOLECULAR PARTNERS AG

    Inventor： Hans Kaspar Binz ,  Patrik Forrer ,  Michael Tobias Stumpp

    IPC: A61K38/16 ,  C07K14/515 ,  A61P43/00 ,  A61K47/48 ,  C07K14/47 ,  C07K17/08 ,  C07K14/00 ,  C07K19/00 ,  A61K38/00

    CPC classification number: A61K38/1709 ,  A61K38/00 ,  A61K38/16 ,  A61K47/60 ,  C07K14/00 ,  C07K14/47 ,  C07K17/08 ,  C07K19/00 ,  C07K2319/74

    Abstract: The present invention relates to binding proteins specific for Vascular Endothelial Growth Factor A (VEGF-A), in particular to recombinant binding proteins comprising a polyethylene glycol moiety and a binding domain, which inhibits VEGF-Axxx (wherein xxx denotes the amino acid length of the VEGF-A mature protein) binding to Vascular Endothelial Growth Factor Receptor 2 (VEGFR-2). Examples of such recombinant binding proteins are proteins which comprise an ankyrin repeat domain with the desired binding specificity, and a polyethylene glycol moiety. The binding proteins are useful in the treatment of cancer and other pathological conditions, e.g. eye diseases such as age-related macular degeneration.

    Abstract translation: 本发明涉及对血管内皮生长因子A（VEGF-A）特异性的结合蛋白质，特别是涉及抑制VEGF-Axxx（其中xxx表示氨基酸长度）的重组结合蛋白，其包含聚乙二醇部分和结合结构域 VEGF-A成熟蛋白）结合血管内皮生长因子受体2（VEGFR-2）。 这种重组结合蛋白的实例是包含具有所需结合特异性的锚蛋白重复结构域的蛋白质和聚乙二醇部分。 结合蛋白可用于治疗癌症和其它病理状态，例如， 眼睛疾病如年龄相关性黄斑变性。

    BINDING PROTEINS INHIBITING THE VEGF-A RECEPTOR INTERACTION
    3.
    发明申请
    BINDING PROTEINS INHIBITING THE VEGF-A RECEPTOR INTERACTION 审中-公开
    结合蛋白抑制VEGF-A受体相互作用

    公开(公告)号：US20150344539A1

    公开(公告)日：2015-12-03

    申请号：US14525553

    申请日：2014-10-28

    Applicant: Molecular Partners AG

    Inventor： Hans Kaspar BINZ ,  Patrik Forrer ,  Michael Tobias Stumpp

    IPC: C07K14/47

    CPC classification number: C07K14/47 ,  A61K38/00 ,  A61K47/60 ,  C07K14/4703

    Abstract: The present invention relates to binding proteins specific for VEGF-A, in particular to recombinant binding proteins comprising a binding domain, which inhibits VEGF-Axxx binding to VEGFR-2. Examples of such binding proteins are proteins which comprise an ankyrin repeat domain with the desired binding specificity. The binding proteins are useful in the treatment of cancer and other pathological conditions, e.g. eye diseases such as age-related macular degeneration.

    Abstract translation: 本发明涉及对VEGF-A特异性的结合蛋白，特别是涉及抑制VEGF-Axxx与VEGFR-2结合的结合结构域的重组结合蛋白。 这种结合蛋白的实例是包含具有所需结合特异性的锚蛋白重复结构域的蛋白质。 结合蛋白可用于治疗癌症和其它病理状态，例如， 眼睛疾病如年龄相关性黄斑变性。

    RECOMBINANT BINDING PROTEINS AND THEIR USE
    5.
    发明申请
    RECOMBINANT BINDING PROTEINS AND THEIR USE 审中-公开

    公开(公告)号：US20190263869A1

    公开(公告)日：2019-08-29

    申请号：US16178923

    申请日：2018-11-02

    Applicant: Molecular Partners AG

    Inventor： Talitha Bakker ,  Michael T. Stumpp ,  Hans Kaspar Binz ,  Douglas Phillips ,  Ignacio Dolado ,  Patrik Forrer ,  Frieder W. Merz ,  Ivo Sonderegger ,  Daniel Steiner ,  Maya Gulotti-Georgieva ,  Johan Abram Saliba

    IPC: C07K14/00 ,  C07K14/47

    Abstract: New designed ankyrin repeat domains with binding specificity for serum albumin, recombinant binding proteins comprising at least two designed ankyrin repeat domains with binding specificity for serum albumin, as well as recombinant binding proteins comprising at least one designed ankyrin repeat domain with binding specificity for hepatocyte growth factor (HGF), at least one designed ankyrin repeat domain with binding specificity for vascular endothelial growth factor (VEGF-A), and at least two designed ankyrin repeat domain with binding specificity for serum albumin are described, as well as nucleic acids encoding such designed ankyrin repeat domains and recombinant binding proteins, pharmaceutical compositions comprising such designed ankyrin repeat domains, recombinant binding proteins or nucleic acids and the use of such designed ankyrin repeat domains, recombinant binding proteins, nucleic acids or pharmaceutical compositions in the treatment of diseases.

    Recombinant proteins that simultaneously bind HGF, VEGF-A and serum albumin, comprising ankyrin repeat domains
    9.
    发明授权
    Recombinant proteins that simultaneously bind HGF, VEGF-A and serum albumin, comprising ankyrin repeat domains 有权
    同时结合HGF，VEGF-A和血清白蛋白的重组蛋白，包含锚蛋白重复结构域

    公开(公告)号：US09458211B1

    公开(公告)日：2016-10-04

    申请号：US15089014

    申请日：2016-04-01

    Applicant: Molecular Partners AG

    Inventor： Talitha Bakker ,  Michael T. Stumpp ,  Hans Kaspar Binz ,  Douglas Phillips ,  Ignacio Dolado ,  Patrik Forrer ,  Frieder W. Merz ,  Ivo Sonderegger ,  Daniel Steiner ,  Maya Gulotti-Georgieva ,  Johan Abram Saliba

    IPC: C07K14/47 ,  A61K38/00 ,  C12N15/62

    CPC classification number: C07K14/001 ,  A61K38/00 ,  C07K14/47 ,  C07K14/4703 ,  C07K2318/20 ,  C07K2319/00 ,  C07K2319/31 ,  C07K2319/70 ,  C12N15/62

    Abstract: New designed ankyrin repeat domains with binding specificity for serum albumin, recombinant binding proteins comprising at least two designed ankyrin repeat domains with binding specificity for serum albumin, as well as recombinant binding proteins comprising at least one designed ankyrin repeat domain with binding specificity for hepatocyte growth factor (HGF), at least one designed ankyrin repeat domain with binding specificity for vascular endothelial growth factor (VEGF-A), and at least two designed ankyrin repeat domain with binding specificity for serum albumin are described, as well as nucleic acids encoding such designed ankyrin repeat domains and recombinant binding proteins, pharmaceutical compositions comprising such designed ankyrin repeat domains, recombinant binding proteins or nucleic acids and the use of such designed ankyrin repeat domains, recombinant binding proteins, nucleic acids or pharmaceutical compositions in the treatment of diseases.

    Abstract translation: 新设计的对血清白蛋白具有结合特异性的锚蛋白重复结构域，包含至少两个设计的对血清白蛋白具有结合特异性的设计的锚蛋白重复结构域的重组结合蛋白，以及包含至少一个设计的具有对肝细胞生长具有结合特异性的设计的锚蛋白重复结构域的重组结合蛋白 描述了至少一个具有对血管内皮生长因子（VEGF-A）具有结合特异性的至少一个设计的锚蛋白重复结构域和至少两个对血清白蛋白具有结合特异性的设计的锚蛋白重复结构域，以及编码这样的核酸 设计的锚蛋白重复结构域和重组结合蛋白，包含这种设计的锚蛋白重复结构域的药物组合物，重组结合蛋白或核酸，以及这些设计的锚蛋白重复结构域，重组结合蛋白，核酸或药物组合物在治疗疾病中的用途。

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