公开(公告)号：US20240279309A1

公开(公告)日：2024-08-22

申请号：US17925138

申请日：2021-05-14

Applicant: MOLECULAR PARTNERS AG

Inventor： Valérie Perrine CALABRO ,  Nicolo RIGAMONTI ,  Clara DOMKE ,  Anja Christina SCHLEGEL

IPC: C07K14/705 ,  A61K38/00

CPC classification number: C07K14/70575 ,  A61K38/00 ,  C07K2319/01

Abstract: The present invention relates to recombinant binding proteins comprising a designed ankyrin repeat domain with binding specificity for CD40. In addition, the invention relates to nucleic acids encoding such binding proteins, pharmaceutical compositions comprising such binding proteins or nucleic acids, and the use of such binding proteins, nucleic acids or pharmaceutical compositions in methods for activating CD40 in cells expressing CD40, e.g., tumor-localized B-cells, and for treating or diagnosing diseases, such as cancer, in a mammal, including a human.

公开(公告)号：US20240156980A1

公开(公告)日：2024-05-16

申请号：US18281152

申请日：2022-03-09

Applicant: MOLECULAR PARTNERS AG

Inventor： Andreas BOSSHART ,  Sebastian GRIMM ,  Julia AHLSKOG ,  Bernd SCHLERETH

IPC: A61K47/68 ,  A61P35/00

CPC classification number: A61K47/6889 ,  A61K47/6811 ,  A61K47/6843 ,  A61K47/6849 ,  A61K47/6851 ,  A61P35/00

Abstract: The application relates to prodrugs comprising a drug molecule connected by a protease-cleavable peptide linker to a binder, which reversibly inhibits a biological activity of the drug molecule, and to the inhibitory binders themselves. Also described are nucleic acids encoding the recombinant proteins described herein, and methods of making said recombinant proteins, as well as methods of treatment and medical uses of the recombinant proteins.

公开(公告)号：US20240124535A1

公开(公告)日：2024-04-18

申请号：US17596102

申请日：2020-06-03

Applicant: MOLECULAR PARTNERS AG

Inventor： Johannes SCHILLING ,  Marcel WALSER

IPC: C07K14/47

CPC classification number: C07K14/47 ,  A61K38/00 ,  C07K2319/21 ,  C07K2319/70

Abstract: The present disclosure relates to designed ankyrin repeat domains with binding specificity for serum albumin and, in particular, to such designed ankyrin repeat domains with improved stability. The disclosure further relates to recombinant binding proteins comprising such designed ankyrin repeat domain(s), nucleic acids encoding such designed ankyrin repeat domains or proteins, pharmaceutical compositions comprising such proteins and the use of such proteins or pharmaceutical compositions in the treatment of diseases.

公开(公告)号：US20240108746A1

公开(公告)日：2024-04-04

申请号：US18267282

申请日：2021-12-16

Applicant: MOLECULAR PARTNERS AG

Inventor： Andreas BOSSHART ,  Julia AHLSKOG ,  Bernd SCHLERETH ,  Patrick AMSTUTZ ,  Simon FONTAINE

IPC: A61K47/68 ,  C07K14/725 ,  C07K16/28

CPC classification number: A61K47/6849 ,  C07K14/7051 ,  C07K16/2809 ,  A61K2039/505 ,  C07K2317/76 ,  C07K2317/92

Abstract: The present invention relates to compositions comprising a binding moiety and a drug molecule, wherein said binding moiety reversibly binds to said drug molecule to form a prodrug complex that slowly releases the drug molecule upon administration in vivo. The present invention further relates to methods of forming such compositions and to methods of treatment using such compositions. Also described are binding moieties, nucleic acids encoding said binding moieties and methods of making these using host cells.

公开(公告)号：US20230340698A1

公开(公告)日：2023-10-26

申请号：US18153576

申请日：2023-01-12

Applicant: MOLECULAR PARTNERS AG

Inventor： Hans Kaspar BINZ ,  Johannes SCHILLING ,  Patrik FORRER ,  Victor LEVITSKY ,  Natalia VENETZ ,  Marcel WALSER

IPC: C40B40/10 ,  C07K14/47

CPC classification number: C40B40/10 ,  C07K14/47 ,  A61K38/00

Abstract: The present invention relates to designed ankyrin repeat domains with altered surface residues, as well as to proteins comprising such a designed ankyrin repeat domain, nucleic acids encoding such domains or proteins, methods of preparing such proteins, pharmaceutical compositions comprising such proteins or nucleic acids, and the use of such proteins, nucleic acids or pharmaceutical compositions in the treatment of diseases.

公开(公告)号：US11453708B2

公开(公告)日：2022-09-27

申请号：US14891792

申请日：2014-06-02

Applicant: Molecular Partners AG

Inventor： Gaby Tresch ,  Talitha Bakker ,  Douglas Phillips ,  Frieder W. Merz ,  Kaspar H. Binz

IPC: C07K14/47 ,  C07K14/475 ,  A61K38/00

Abstract: New designed ankyrin repeat proteins with binding specificity for HGF are described, as well as nucleic acids encoding such HGF binding proteins, pharmaceutical compositions comprising such proteins and the use of such proteins in the treatment of diseases.

公开(公告)号：US11332501B2

公开(公告)日：2022-05-17

申请号：US16178923

申请日：2018-11-02

Applicant: Molecular Partners AG

Inventor： Talitha Bakker ,  Michael T. Stumpp ,  Hans Kaspar Binz ,  Douglas Phillips ,  Ignacio Dolado ,  Patrik Forrer ,  Frieder W. Merz ,  Ivo Sonderegger ,  Daniel Steiner ,  Maya Gulotti-Georgieva ,  Johan Abram Saliba

IPC: C07K14/00 ,  C07K14/47 ,  A61K38/00 ,  C12N15/62

Abstract: New designed ankyrin repeat domains with binding specificity for serum albumin, recombinant binding proteins comprising at least two designed ankyrin repeat domains with binding specificity for serum albumin, as well as recombinant binding proteins comprising at least one designed ankyrin repeat domain with binding specificity for hepatocyte growth factor (HGF), at least one designed ankyrin repeat domain with binding specificity for vascular endothelial growth factor (VEGF-A), and at least two designed ankyrin repeat domain with binding specificity for serum albumin are described, as well as nucleic acids encoding such designed ankyrin repeat domains and recombinant binding proteins, pharmaceutical compositions comprising such designed ankyrin repeat domains, recombinant binding proteins or nucleic acids and the use of such designed ankyrin repeat domains, recombinant binding proteins, nucleic acids or pharmaceutical compositions in the treatment of diseases.

公开(公告)号：US20220106707A1

公开(公告)日：2022-04-07

申请号：US17392204

申请日：2021-08-02

Applicant: MOLECULAR PARTNERS AG

Inventor： Victor LEVITSKY ,  Natalia VENETZ ,  Marcel WALSER ,  Kaspar BINZ ,  Johannes SCHILLING ,  Patrik FORRER

IPC: C40B40/10 ,  C07K14/47

Abstract: The present invention relates to a method of producing recombinant binding proteins with binding specificity for a peptide-MHC (pMHC) complex. The invention also relates to recombinant binding proteins comprising one, two or more designed repeat domain(s), preferably designed ankyrin repeat domain(s), with binding specificity for a pMHC complex, and to such binding proteins which further comprise a binding agent having binding specificity for a protein expressed on the surface of an immune cell, preferably a T-cell. In addition, the invention relates to nucleic acids encoding such binding proteins or repeat domains, pharmaceutical compositions comprising such binding proteins or nucleic acids, and the use of such binding proteins, nucleic acids or pharmaceutical compositions in methods for treating or diagnosing diseases, including cancer, infectious diseases and autoimmune diseases.

公开(公告)号：US20190263869A1

公开(公告)日：2019-08-29

申请号：US16178923

申请日：2018-11-02

Applicant: Molecular Partners AG

Inventor： Talitha Bakker ,  Michael T. Stumpp ,  Hans Kaspar Binz ,  Douglas Phillips ,  Ignacio Dolado ,  Patrik Forrer ,  Frieder W. Merz ,  Ivo Sonderegger ,  Daniel Steiner ,  Maya Gulotti-Georgieva ,  Johan Abram Saliba

IPC: C07K14/00 ,  C07K14/47

Abstract: New designed ankyrin repeat domains with binding specificity for serum albumin, recombinant binding proteins comprising at least two designed ankyrin repeat domains with binding specificity for serum albumin, as well as recombinant binding proteins comprising at least one designed ankyrin repeat domain with binding specificity for hepatocyte growth factor (HGF), at least one designed ankyrin repeat domain with binding specificity for vascular endothelial growth factor (VEGF-A), and at least two designed ankyrin repeat domain with binding specificity for serum albumin are described, as well as nucleic acids encoding such designed ankyrin repeat domains and recombinant binding proteins, pharmaceutical compositions comprising such designed ankyrin repeat domains, recombinant binding proteins or nucleic acids and the use of such designed ankyrin repeat domains, recombinant binding proteins, nucleic acids or pharmaceutical compositions in the treatment of diseases.

公开(公告)号：US20160263185A1

公开(公告)日：2016-09-15

申请号：US15015902

申请日：2016-02-04

Applicant: Molecular Partners AG

Inventor： Hans Kaspar BINZ ,  Patrik FORRER ,  Michael Tobias STUMPP

IPC: A61K38/17 ,  A61K47/48

CPC classification number: A61K38/1709 ,  A61K38/00 ,  A61K38/16 ,  A61K47/60 ,  C07K14/00 ,  C07K14/47 ,  C07K17/08 ,  C07K19/00 ,  C07K2319/74

Abstract: The present invention relates to binding proteins specific for VEGF-A, in particular to recombinant binding proteins comprising a polyethylene glycol moiety and a binding domain, which inhibits VEGF-Axxx binding to VEGFR-2. Examples of such recombinant binding proteins are proteins which comprise an ankyrin repeat domain with the desired binding specificity, and a polyethylene glycol moiety. The binding proteins are useful in the treatment of cancer and other pathological conditions, e.g. eye diseases such as age-related macular degeneration.