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    DESIGNED REPEAT DOMAINS WITH DUAL BINDING SPECIFICITY AND THEIR USE
    1.
    发明申请
    DESIGNED REPEAT DOMAINS WITH DUAL BINDING SPECIFICITY AND THEIR USE 有权

    公开(公告)号：US20250042957A1

    公开(公告)日：2025-02-06

    申请号：US18719008

    申请日：2022-12-14

    Applicant: Molecular Partners AG

    Inventor： Simon Fontaine ,  Andreas Bosshart ,  Bernd Schlereth ,  Daniel Steiner ,  Marcel Walser

    IPC: C07K14/47 ,  A61K38/00 ,  A61K45/06

    Abstract: The present invention relates to a method of producing a designed repeat domain which has binding specificity for two targets, wherein binding of such repeat domain to its two targets is mutually exclusive. Said designed repeat domain is preferably a designed ankyrin repeat domain. The invention also provides such designed repeat domains and recombinant proteins comprising such repeat domains, as well as the use of such repeat domains as molecular switches, such as, e.g., switches to control activation or deactivation of a therapeutic agent. The invention further relates to nucleic acids encoding such repeat domains or recombinant proteins, pharmaceutical compositions comprising such recombinant proteins, repeat domains or nucleic acids, recombinant expression vectors and host cells, and the use of such proteins, nucleic acids or pharmaceutical compositions in methods for treating diseases, such as cancer.

    Recombinant proteins that simultaneously bind HGF, VEGF-A and serum albumin, comprising ankyrin repeat domains
    2.
    发明授权
    Recombinant proteins that simultaneously bind HGF, VEGF-A and serum albumin, comprising ankyrin repeat domains 有权
    同时结合HGF，VEGF-A和血清白蛋白的重组蛋白，包含锚蛋白重复结构域

    公开(公告)号：US09458211B1

    公开(公告)日：2016-10-04

    申请号：US15089014

    申请日：2016-04-01

    Applicant: Molecular Partners AG

    Inventor： Talitha Bakker ,  Michael T. Stumpp ,  Hans Kaspar Binz ,  Douglas Phillips ,  Ignacio Dolado ,  Patrik Forrer ,  Frieder W. Merz ,  Ivo Sonderegger ,  Daniel Steiner ,  Maya Gulotti-Georgieva ,  Johan Abram Saliba

    IPC: C07K14/47 ,  A61K38/00 ,  C12N15/62

    CPC classification number: C07K14/001 ,  A61K38/00 ,  C07K14/47 ,  C07K14/4703 ,  C07K2318/20 ,  C07K2319/00 ,  C07K2319/31 ,  C07K2319/70 ,  C12N15/62

    Abstract: New designed ankyrin repeat domains with binding specificity for serum albumin, recombinant binding proteins comprising at least two designed ankyrin repeat domains with binding specificity for serum albumin, as well as recombinant binding proteins comprising at least one designed ankyrin repeat domain with binding specificity for hepatocyte growth factor (HGF), at least one designed ankyrin repeat domain with binding specificity for vascular endothelial growth factor (VEGF-A), and at least two designed ankyrin repeat domain with binding specificity for serum albumin are described, as well as nucleic acids encoding such designed ankyrin repeat domains and recombinant binding proteins, pharmaceutical compositions comprising such designed ankyrin repeat domains, recombinant binding proteins or nucleic acids and the use of such designed ankyrin repeat domains, recombinant binding proteins, nucleic acids or pharmaceutical compositions in the treatment of diseases.

    Abstract translation: 新设计的对血清白蛋白具有结合特异性的锚蛋白重复结构域，包含至少两个设计的对血清白蛋白具有结合特异性的设计的锚蛋白重复结构域的重组结合蛋白，以及包含至少一个设计的具有对肝细胞生长具有结合特异性的设计的锚蛋白重复结构域的重组结合蛋白 描述了至少一个具有对血管内皮生长因子（VEGF-A）具有结合特异性的至少一个设计的锚蛋白重复结构域和至少两个对血清白蛋白具有结合特异性的设计的锚蛋白重复结构域，以及编码这样的核酸 设计的锚蛋白重复结构域和重组结合蛋白，包含这种设计的锚蛋白重复结构域的药物组合物，重组结合蛋白或核酸，以及这些设计的锚蛋白重复结构域，重组结合蛋白，核酸或药物组合物在治疗疾病中的用途。

    RECOMBINANT BINDING PROTEINS AND THEIR USE
    4.
    发明申请
    RECOMBINANT BINDING PROTEINS AND THEIR USE 审中-公开

    公开(公告)号：US20190263869A1

    公开(公告)日：2019-08-29

    申请号：US16178923

    申请日：2018-11-02

    Applicant: Molecular Partners AG

    Inventor： Talitha Bakker ,  Michael T. Stumpp ,  Hans Kaspar Binz ,  Douglas Phillips ,  Ignacio Dolado ,  Patrik Forrer ,  Frieder W. Merz ,  Ivo Sonderegger ,  Daniel Steiner ,  Maya Gulotti-Georgieva ,  Johan Abram Saliba

    IPC: C07K14/00 ,  C07K14/47

    Abstract: New designed ankyrin repeat domains with binding specificity for serum albumin, recombinant binding proteins comprising at least two designed ankyrin repeat domains with binding specificity for serum albumin, as well as recombinant binding proteins comprising at least one designed ankyrin repeat domain with binding specificity for hepatocyte growth factor (HGF), at least one designed ankyrin repeat domain with binding specificity for vascular endothelial growth factor (VEGF-A), and at least two designed ankyrin repeat domain with binding specificity for serum albumin are described, as well as nucleic acids encoding such designed ankyrin repeat domains and recombinant binding proteins, pharmaceutical compositions comprising such designed ankyrin repeat domains, recombinant binding proteins or nucleic acids and the use of such designed ankyrin repeat domains, recombinant binding proteins, nucleic acids or pharmaceutical compositions in the treatment of diseases.

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