公开(公告)号：US20240108746A1

公开(公告)日：2024-04-04

申请号：US18267282

申请日：2021-12-16

Applicant: MOLECULAR PARTNERS AG

Inventor： Andreas BOSSHART ,  Julia AHLSKOG ,  Bernd SCHLERETH ,  Patrick AMSTUTZ ,  Simon FONTAINE

IPC: A61K47/68 ,  C07K14/725 ,  C07K16/28

CPC classification number: A61K47/6849 ,  C07K14/7051 ,  C07K16/2809 ,  A61K2039/505 ,  C07K2317/76 ,  C07K2317/92

Abstract: The present invention relates to compositions comprising a binding moiety and a drug molecule, wherein said binding moiety reversibly binds to said drug molecule to form a prodrug complex that slowly releases the drug molecule upon administration in vivo. The present invention further relates to methods of forming such compositions and to methods of treatment using such compositions. Also described are binding moieties, nucleic acids encoding said binding moieties and methods of making these using host cells.