公开(公告)号：US20250042957A1

公开(公告)日：2025-02-06

申请号：US18719008

申请日：2022-12-14

Applicant: Molecular Partners AG

Inventor： Simon Fontaine ,  Andreas Bosshart ,  Bernd Schlereth ,  Daniel Steiner ,  Marcel Walser

IPC: C07K14/47 ,  A61K38/00 ,  A61K45/06

Abstract: The present invention relates to a method of producing a designed repeat domain which has binding specificity for two targets, wherein binding of such repeat domain to its two targets is mutually exclusive. Said designed repeat domain is preferably a designed ankyrin repeat domain. The invention also provides such designed repeat domains and recombinant proteins comprising such repeat domains, as well as the use of such repeat domains as molecular switches, such as, e.g., switches to control activation or deactivation of a therapeutic agent. The invention further relates to nucleic acids encoding such repeat domains or recombinant proteins, pharmaceutical compositions comprising such recombinant proteins, repeat domains or nucleic acids, recombinant expression vectors and host cells, and the use of such proteins, nucleic acids or pharmaceutical compositions in methods for treating diseases, such as cancer.

公开(公告)号：US11578427B2

公开(公告)日：2023-02-14

申请号：US17400471

申请日：2021-08-12

Applicant: MOLECULAR PARTNERS AG

Inventor： Hans Kaspar Binz ,  Johannes Schilling ,  Patrik Forrer ,  Victor Levitsky ,  Natalia Venetz ,  Marcel Walser

IPC: C07K14/47 ,  C40B40/10 ,  A61K38/00

Abstract: The present invention relates to designed ankyrin repeat domains with altered surface residues, as well as to proteins comprising such a designed ankyrin repeat domain, nucleic acids encoding such domains or proteins, methods of preparing such proteins, pharmaceutical compositions comprising such proteins or nucleic acids, and the use of such proteins, nucleic acids or pharmaceutical compositions in the treatment of diseases.

公开(公告)号：US11466062B2

公开(公告)日：2022-10-11

申请号：US17313543

申请日：2021-05-06

Applicant: Molecular Partners AG

Inventor： Patrick Amstutz ,  Valerie Perrine Calabro ,  Marcel Walser

IPC: C07K14/47 ,  A61P31/14 ,  A61K38/00

Abstract: The present invention relates to recombinant binding proteins comprising one or more designed ankyrin repeat domains with binding specificity for coronavirus spike proteins, nucleic acids encoding such proteins, pharmaceutical compositions comprising such proteins or nucleic acids, and the use of such proteins, nucleic acids or pharmaceutical compositions in the treatment of coronavirus diseases, particularly diseases caused by SARS-CoV-2.