公开(公告)号：US20210309954A1

公开(公告)日：2021-10-07

申请号：US17279036

申请日：2020-06-18

申请人： MITSUI CHEMICALS, INC.

发明人： Makoto KIYA ,  Hiroshi MIYASAKO ,  Katsutoshi KINOSHITA ,  Tomoaki MATSUGI ,  Takashi ODA ,  Katsuhiro ESASHIKA

IPC分类号： C12M1/00

摘要： A culture material including a 4-methyl-1-pentene polymer for cells, tissues, or organs, the culture material having a water contact angle at a culture surface of 50° to 100°, a sagging distance by a test method described below of 0 to 5 mm, and an oxygen permeation rate at a temperature of 23° C. and a humidity of 0% of 4500 to 90000 cm3/(m2×24 h×atm). A test piece having the same material as the culture material and the same thickness as the culture surface of the culture material and having a flat plate shape of 100 mm long and 10 mm wide is made. The test piece is fixed onto a test board in a state where the test piece protrudes lengthwise in a horizontal direction from a top surface of the test board, the top surface being horizontal.

公开(公告)号：US20180086864A1

公开(公告)日：2018-03-29

申请号：US15562461

申请日：2016-02-15

申请人： MITSUI CHEMICALS, INC.

发明人： Tadahiro SUNAGA ,  Takashi ODA ,  Hisanori OHKITA ,  Hiroshi MIYASAKO

IPC分类号： C08F32/08 ,  C08F14/18 ,  C12M1/00 ,  C08F8/04

CPC分类号： C08F32/08 ,  C08F8/04 ,  C08F14/185 ,  C08G2261/418 ,  C12M23/20 ,  C12N5/0018

摘要： Medical instrument including a substrate using a fluorine-containing cyclic olefin polymer containing a structural unit represented by General Formula (1), in which the substrate has one surface where the substrate comes into contact with cells, and the substrate is provided with a convex-concave structure on the one surface, a ratio (L1/L2) of a width (L1) between convexities formed by the convex-concave structure and a maximum diameter (L2) of inoculated cells per cell in the cells is 1 to 300, and the cells do not adhere to or attach to the one surface provided with the convex-concave structure and the medical instrument promotes cell proliferation. wherein R1 to R4 are defined.

公开(公告)号：US20240301339A1

公开(公告)日：2024-09-12

申请号：US18266951

申请日：2021-12-06

申请人： MITSUI CHEMICALS, INC.

发明人： Katsuhiro ESASHIKA ,  Hiroshi MIYASAKO ,  Takashi KOZEKI ,  Koh AMANO ,  Yoshinobu SAIJO ,  Hisaaki YANAI

IPC分类号： C12M1/12 ,  C12N5/00

CPC分类号： C12M25/14 ,  C12N5/0068 ,  C12N2513/00

摘要： Provided is a culture material and a culture tool, which allow to culture, cells, etc. to form a spheroid.
A culture material for culturing cells, a tissue, or an organ on a culture surface thereof, the culture material containing a 4-methyl-1-pentene polymer (X), having a water contact angle of the culture surface of more than 100° and 160° or less, and having an oxygen permeability at a temperature of 23° C. and humidity of 0% of 4500 to 90000 cm3/(m2×24 h×atm).

公开(公告)号：US20170233696A1

公开(公告)日：2017-08-17

申请号：US15502507

申请日：2015-08-10

申请人： MITSUI CHEMICALS, INC.

发明人： Tadahiro SUNAGA ,  Takashi ODA ,  Hiroshi MIYASAKO ,  Takeshi OSAKA

IPC分类号： C12N5/00 ,  C12M1/00

CPC分类号： C12N5/0068 ,  C12M23/02 ,  C12M23/20 ,  C12M25/06 ,  C12M47/02 ,  C12M47/04

摘要： Medical instrument includes a substrate, in which cells are in contact with or held on a surface of the substrate, and at least the surface of the substrate which holds the cells is formed of a fluorine-containing cyclic olefin polymer which contains a repeating structure unit represented by Formula (1), wherein in Formula (1), at least one of R1 to R4 is fluorine, an alkyl with 1 to 10 carbon atoms which contains fluorine, an alkoxy with 1 to 10 carbon atoms which contains fluorine, or an alkoxyalkyl with 2 to 10 carbon atoms which contains fluorine, R1 to R4 are selected from hydrogen and certain non-fluorinated groups when R1 to R4 do not contain fluorine, R1 to R4 may be the same as or different from each other, and R1 to R4 may be bonded to each other to form a cyclic structure.